Event

Seminar

GEM Work-in-Progress Talk: "Small tumor virus replication: viral helicases and cellular polymerases"

Date:
Monday, November 28, 2022
Time:
4:00 pm - 5:00 pm
Location:
Remote - Zoom presentation
Cost:
NA
Presenter:
Thomas Melendy, PhD, Director, Witebsky Center for Microbial Pathogenesis & Immunology Associate Professor of Microbiology & Immunology, and Biochemistry, Department of Microbiology and Immunology, Jacobs School of Medicine & Biomedical Sciences
Sponsor:
Genome, Environment and Microbiome Community of Excellence (GEM); Office of the Vice President for Research and Economic Development (OVPRED)

Please join us on Monday, November 28th for a GEM Work-in-Progress talk presented by Thomas Melendy, PhD, Director of the Witebsky Center for Microbial Pathogenesis & Immunology and Associate Professor of Microbiology & Immunology, and Biochemistry for the Department of Microbiology and Immunology in the Jacobs School of Medicine & Biomedical Sciences.

Title: "Small tumor virus replication: viral helicases and cellular polymerases"

Summary: Human polyomaviruses and papillomaviruses are two families of viruses that infect the majority of humans, and a small percentage of these infections can lead to cancers - altogether these cause over 5% of all human cancers. We have a longstanding interest in how these viruses recruit and utilize cellular DNA synthesis enzymes to replicate their viral genomes, and whether this information can be leveraged for antiviral approaches. The replication of polyomavirus genomes is responsive to cellular DNA damage response pathways to slow down DNA replication forks to allow additional time for DNA repair. Our studies on regulating replication fork progression provide insights into DNA replication stress, a new target for anti-cancer therapeutic approaches.

Join Zoom Meeting
https://buffalo.zoom.us/j/96390449124?pwd=WURjdDRXTkVySzViK3RjeFE4T1RUZz09

Meeting ID: 963 9044 9124
Passcode: 985706

These informal talks are part of the GEM Work-in-Progress series held at 4:00 p.m. on the 4th Monday of each month. Talks will take place remotely via Zoom. The speaker schedule is available on the GEM website: www.buffalo.edu/gem.

GEM is seeking faculty, post-doc and student speakers whose work focuses on genomics, the environment or the microbiome for our GEM Work-In-Progress series! If you would like to present at a GEM Work-in-Progress session, please contact us at msthomas@buffalo.edu and we will get you onto the schedule.

Links

Attachments

For more information, contact:

Sara Thomas
Email: msthomas@buffalo.edu