Event

Please join us on Monday, February 26th for a GEM Work-in-Progress talk presented by Dahong Chen, PhD, Assistant Professor in the UB Department of Biochemistry.

Title: Regulation of global transcription by chromatin architectural proteins in retina

Description: Chromatin architecture represents nuclear 3D organization and plays a critical role to ensure proper and dynamic transcription. Dysregulated chromatin architecture has been attributed to a variety of diseases including intellectual and neurological disorders that affect 16% of the children in the US, and chromatin regulatory factors are among top disease risk genes. However, few studies elucidate how these factors function on chromatin in an in vivo context due to the extraordinary cellular complexity of the nervous system. We integrate flow cytometry with multi-omics analyses to elucidate epigenomic mechanisms underlying neuronal development with unparalleled cell type resolution and solid quantification. Our preliminary data indicate that chromatin architectural proteins facilitate neuronal development by regulating global transcription and chromatin accessibility, particularly at enhancers. Our findings provide unprecedented chromatin-related mechanisms to guide medical and clinical studies toward neurological diseases.

These informal talks are part of the GEM Work-in-Progress series held at 4:00 p.m. on the last Monday of each month. The speaker schedule is available on the GEM website: www.buffalo.edu/gem.

GEM is always seeking UB faculty, post-doc and student speakers whose work focuses on genomics, the environment AND/OR the microbiome for our GEM Work-In-Progress series! If you would like to present at a GEM Work-in-Progress session, please contact Sara Thomas at msthomas@buffalo.edu.

Sara Thomas
Email: msthomas@buffalo.edu