My dissertation research focuses on improving human oligodendrocyte progenitor cell transplantation as a therapeutic strategy for central nervous system regeneration. I investigate biological and microenvironmental factors that influence transplanted cell survival, integration, and differentiation, with the goal of identifying strategies to improve the efficacy of cell-based approaches for myelin repair. My work integrates human glial and induced pluripotent stem cell biology with transplantation models, pharmacological approaches, and biomaterials to address barriers to successful regenerative cell therapy.

Fraser Sim, PhD