Sailee Rasam
BPharm ’13, Mumbai University
MS '16, Biotechnology, University at Buffalo
Thesis Title
Proteomics Based Characterization of Cancer and Cardiovascular Disease Models & Advancement of MHC-Peptidome Identification Strategies for High Fidelity Discovery.
Publications
- Rasam, S.; Lin, Q.; Shen, S.; Straubinger, R.; Qu, J., Highly reproducible quantitative proteomics analysis of pancreatic cancer cells reveals proteome-level effects of a novel combination drug therapy that induces cancer cell death via metabolic remodeling and activation of the extrinsic apoptosis pathway. American Chemical Society 2023, 22(12), 3780-3792.
- Kaur, R.; Mangiafesto, J.; Pryharski, K.; Rasam. S.; Zagursky, R.; Pichichero, M., Expression conditions and characterization of a novelly-constructed lipoprotein intended as a vaccine to prevent human Haemophilus influenzae infections. American Society for Biochemistry and Molecular Biology 2023, 299(8).
- Shen, S.; Wang, X.; Zhu, X.; Rasam, S.; Ma, M.; Huo, S.; Qian, S.; Zhang, M.; Qu, M.; Hu, C., High-quality and robust protein quantification in large clinical/pharmaceutical cohorts with IonStar proteomics investigation. Nature Protocols 2023, 18 (3), 700-731.
- Ma, M.; Huo, S.; Zhang, M.; Qian, S.; Zhu, X.; Pu, J.; Rasam, S.; Xue, C.; Shen, S.; An, B., In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP). Nature Communications 2022, 13 (1), 7736.
- Lin, Q.; Shen, S.; Qian, Z.; Rasam, S. S.; Serratore, A.; Jusko, W. J.; Kandel, E. S.; Qu, J.; Straubinger, R. M., Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer. Molecular & Cellular Proteomics 2022, 21 (10).
- Hilchey, S. P.; Palshikar, M. G.; Mendelson, E. S.; Shen, S.; Rasam, S.; Emo, J. A.; Qu, J.; Thakar, J.; Zand, M. S., Cyclosporine A modulates LSP1 protein levels in Human B cells to attenuate B cell migration at low O2 Levels. Life 2022, 12 (8), 1284.
- Shen, S.; Zhang, M.; Ma, M.; Rasam, S.; Poulsen, D.; Qu, J., Potential neuroprotective mechanisms of methamphetamine treatment in traumatic brain injury defined by large-scale ionstar-based quantitative proteomics. International Journal of Molecular Sciences 2021, 22 (5), 2246.
- Shen, S.; Li, J.; Huo, S.; Ma, M.; Zhu, X.; Rasam, S.; Duan, X.; Qu, M.; Titus, M. A.; Qu, J., Parallel, High-quality proteomic and targeted metabolomic quantification using laser capture microdissected tissues. Analytical Chemistry 2021, 93 (25), 8711-8718.
- Santha, S.; Ling, X.; Aljahdali, I. A.; Rasam, S. S.; Wang, X.; Liao, J.; Wang, J.; Fountzilas, C.; Li, Q.; Qu, J., Mutant Kras as a biomarker plays a favorable role in FL118-induced apoptosis, reactive oxygen species (ROS) production and modulation of Survivin, mcl-1 and XIAP in human bladder cancer. Cancers 2020, 12 (11), 3413.
- Wang, X.; Shen, S.; Rasam, S. S.; Qu, J., MS1 ion current‐based quantitative proteomics: A promising solution for reliable analysis of large biological cohorts. Mass spectrometry reviews 2019, 38 (6), 461-482.
Professional/Educational Meetings/Abstracts
- Sailee Rasam; Shichen Shen; Qingxiang Lin; Xue Wang; Robert Straubinger; Jun Qu. Effects of New Combination Therapy in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cell Lines Using Highly Reproducible, Ion-Current Based Quantitative Proteomics. ASMS 2019.
- Sailee Rasam; Brian R. Weil; John M. Canty, Jr.; Jun Qu. Quantitative Proteomic and Phosphoproteomic Profiling of Myocardial Remodeling in a Porcine Model of Left Ventricular Stiffening Following Chronic Repetitive Pressure-Overload. ASMS 2020 (Virtual)
- Sailee Rasam; Shichen Shen; Shuo Qian; Ming Zhang; Jun Qu. Enhancement on IonStar Using Off-line Fractionation to Increase Protein Quantitative Depth. ASMS 2020. (Virtual)
- Sailee Rasam; Shichen Shen; Qingxiang Lin; Robert M. Straubinger; Jun Qu A highly-robust, reproducible, quantitative proteomics pipeline reveals metabolic, apoptotic, and immunological responses of pancreatic cancer cells to novel drug combinations. ASMS 2021