Pablo M. Paez PhD
Pablo M. Paez
PhD
Professor
Department of Pharmacology and Toxicology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Ion channel kinetics and structure; Molecular and Cellular Biology; Neurobiology; Neuropharmacology
Professional Summary:
Our research program focuses on brain development, studying the development of the oligodendroglial and astroglial cell lineages in the central nervous system in normal, mutant and transgenic mice. The primary focus in the laboratory is on ion channels that regulate specification, migration and differentiation of these glial cells.
The oligodendrocyte generates CNS myelin, which is essential for normal nervous system function. Thus, investigating the regulatory and signaling mechanisms that control its differentiation and the production of myelin is relevant to our understanding of brain development and of adult pathologies such as multiple sclerosis. We have recently discovered that voltage-gated Ca++ channels are necessary for normal myelination acting at multiple steps during oligodendrocyte progenitor cells (OPCs) development, however nothing is known about its role in demyelination or remyelination events. Our research aims to determine if voltage-gated Ca++ channels plays a functional role in myelin repair. Using transgenic mice and new imaging techniques we are testing the hypothesis that voltage-gated Ca++ entry promotes OPC survival and proliferation in the remyelinating adult brain. Therefore, this work is relevant to developing means to induce remyelination in myelin degenerative diseases and for myelin repair in damaged nervous tissue.
Astrocytes are the most abundant cell of the human brain. They perform many functions, including biochemical support of endothelial cells that form the blood brain barrier, provision of nutrients to the nervous tissue and a role in the repair and scarring process of the brain and spinal cord following traumatic injuries. Our lab has made the novel finding of voltage-gated Ca++ channels function in astrocyte Ca++ homeostasis, and this has implications for plasticity in astrocyte development and for Ca++ regulation in general. We are testing the hypothesis that voltage-gated Ca++ entry plays a key role in astrocyte function and glial-neuronal interactions. We have generated a conditional knockout mice for voltage-gated Ca++ channels in astrocytes, these conditional knockout mice will allow the functional analysis of voltage-gated Ca++ channels in astroglia of the postnatal and adult brain. Analyzing such mice using a combination of behavioral, electrophysiological, imaging, and immunohistochemical techniques will provide new insights in our understanding of astroglial contribution to brain function.
These projects have been supported for many years by grants from the NIH and the National Multiple Sclerosis Society.
Education and Training:
- Fellowship, Dev. Neuroscience, University of California at Los Angeles, David Geffen School of Medicine, Department of Psychiatry & Biobehavioral Sciences (2010)
- PhD, Neuroscience, University of Buenos Aires, School of Pharmacy and Biochemistry (2005)
- BS, Biochemistry, University of Buenos Aires, School of Pharmacy and Biochemistry (2000)
Employment:
- Professor, Pharmacology and Toxicology, University at Buffalo, The State University of New York, Jacobs School of Medicine & Biomedical Sciences (2024-present)
- Associate Professor, Pharmacology and Toxicology, University at Buffalo, The State University of New York, Jacobs School of Medicine & Biomedical Sciences (2018-present)
- Assistant Professor, Pharmacology and Toxicology, University at Buffalo, The State University of New York, Jacobs School of Medicine & Biomedical Sciences (2013–2018)
- Research Associate Professor, Department of Psychiatry & Biobehavioral Sciences, University of California at Los Angeles David Geffen School of Medicine (2010–2013)
- Post Doctoral Fellow, Department of Psychiatry & Biobehavioral Sciences, University of California at Los Angeles David Geffen School of Medicine (2006–2010)
- Research Assistant, Department of Biochemical Pathology, University of Buenos Aires School of Pharmacy and Biochemistry (2000–2005)
- Teaching & Research Assistant, Department of Biochemical Pathology, University of Buenos Aires School of Pharmacy and Biochemistry (2000–2004)
Awards and Honors:
- Searle Scholar Award of the UB Jacobs School of Medicine and Biomedical Sciences (2013)
- International Society for Neurochemistry and European Society for Neurochemistry Travel Award (2011)
- American Society for Neurochemistry, Young Investigator Educational Enhancement Award (2008)
- BRI/Semel Institute Neuroscience Postdoctoral Fellows Travel Award (2008)
- Fine Science Tools Postdoctoral Scholars Travel Award (2008)
- National Multiple Sclerosis Society Fellowship Award (FG 1723A1/1) (2007)
- UCLA Friends of the Semel Institute for Neuroscience and Human Behavior Travel Award (2007)
- International Society for Neurochemistry and American Society for Neurochemistry Travel Award (2007)
- GLIA Stipend, VII European Meeting on Glia Cells in Health and Disease (2005)
- IBRO-financed travel support, VII European Meeting on Glia Cells in Health and Disease (2005)
- American Society for Neurochemistry Young Investigator Educational Enhancement Award (2005)
- Committee for Aid and Education in Neurochemistry (CAEN) of the ISN, CAEN Fellowship (2004)
- American Society for Neurochemistry, Young Latin American Scholars Award (2003)
- American Society for Neurochemistry, Young Investigator Educational Enhancement Award (2002)
Research Expertise:
- Neuroscience, Neurochemistry and Molecular Biology
Grants and Sponsored Research:
- December 2021–November 2027
Modulation of oligodendrocyte development by voltage-operated calcium channels
National Institute of Neurological Disorders and Stroke (NINDS)
Role: Principal Investigator
$1,993,750 - February 2019–January 2024
The peripheral nervous system: a window into Krabbe disease
National Institute of Neurological Disorders and Stroke (NINDS)
Role: Co-Investigator
$1,929,000 - July 2021–June 2023
Role of Pacs2 in central nervous system myelination
National Institute of Neurological Disorders and Stroke (NINDS)
Role: Co-Investigator
$439,000 - December 2017–November 2022
Muscarinic Receptor Type 3 Regulation of Oligodendrocyte Progenitor Differentiation
National Institute of Neurological Disorders and Stroke (NINDS)
Role: Co-Investigator
$1,744,000 - April 2019–March 2022
Voltage-gated calcium channels in reactive astrocytes, a possible therapeutic target to reduce brain inflammation and promote remyelination in MS.
National Multiple Sclerosis Society
Role: Principal Investigator
$556,000 - December 2019–November 2021
Systematic discovery of critical oligodendrocyte transcription factors by a CRISPRi Screen
National Institute of Neurological Disorders and Stroke (NINDS)
Role: Co-Investigator
$439,000 - July 2018–June 2021
A Novel Stress-Activated Inhibitor of Myelination
US Army Medical Research Acquisition Activity
Role: Co-Investigator
$890,000 - June 2013–May 2019
Modulation of oligodendrocyte development by voltage-operated calcium channels
National Institute of Neurological Disorders and Stroke (NINDS)
Role: Principal Investigator
$1,940,000 - June 2014–May 2016
Modulation of oligodendrocyte development by voltage-operated calcium channels
National Institute of Neurological Disorders and Stroke (NINDS)
Role: Principal Investigator
$125,000 - October 2011–September 2015
Modulation of oligodendrocyte function and myelination by the golli proteins
National Multiple Sclerosis Society
Role: Principal Investigator
$571,000 - October 2012–April 2013
Modulation of oligodendrocyte development by voltage-operated calcium channels
National Multiple Sclerosis Society
Role: Principal Investigator
$353,000 - October 2011–September 2012
The Role of Voltage-operated Ca++ channels during oligodendrocyte development
National Multiple Sclerosis Society
Role: Principal Investigator
$44,000 - October 2009–September 2012
Goli-mpb gene expression in the nervous system
National Multiple Sclerosis Society
Role: Principal Investigator
$480,000 - April 2007–March 2010
Golli Proteins and calcium homeostasis in oligodendroglial maturation
National Multiple Sclerosis Society
Role: Principal Investigator
$150,000
Journal Articles:
- Smith Z, Cheli VT, Angeliu CG, Wang C, Denaroso GE, Tumuluri SG, Corral J, Garbarini K, Paez PM. (2024) Ferritin loss in astrocytes reduces spinal cord oxidative stress and demyelination in the experimental autoimmune encephalomyelitis (EAE) model. Glia (Sep).
- Denaroso GE, Smith Z, Angeliu CG, Cheli VT, Wang C, Paez PM. (2023) Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis. Journal of neuroinflammation (Nov), 20(1): 263.
- Cheli VT, Sekhar M, Santiago González DA, Angeliu CG, Denaroso GE, Smith Z, Wang C, Paez PM. (2023) The expression of ceruloplasmin in astrocytes is essential for postnatal myelination and myelin maintenance in the adult brain. Glia (Jun).
- Cheli VT, Santiago González DA, Wan R, Rosenblum SL, Denaroso GE, Angeliu CG, Smith Z, Wang C, Paez PM. (2023) Transferrin receptor is necessary for proper oligodendrocyte iron homeostasis and development. The Journal of neuroscience : the official journal of the Society for Neuroscience (Mar).
- Pérez MJ, Carden TR, Dos Santos Claro PA, Silberstein S, Páez PM, Cheli VT, Correale J, Pasquini JM. (2023) Transferrin Enhances Neuronal Differentiation. ASN neuro (Jan), 15: 17590914231170703.
- Dupree JL, Paez PM, Tiwari-Woodruff SK, Denton TT, Hensley K, Angeliu CG, Boullerne AI, Kalinin S, Egge S, Cheli VT, Denaroso G, Atkinson KC, Feri M, Feinstein DL. (2022) Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis. ASN neuro (Jul), 14: 17590914221112352.
- Santiago González DA, Cheli VT, Rosenblum SL, Denaroso G, Paez PM. (2021) Ceruloplasmin deletion in myelinating glial cells induces myelin disruption and oxidative stress in the central and peripheral nervous systems. Redox biology (Aug), 46: 102118. doi:10.1016/j.redox.2021.102118
- Cheli VT, Santiago González DA, Wan Q, Denaroso G, Wan R, Rosenblum SL, Paez PM. (2021) H-ferritin expression in astrocytes is necessary for proper oligodendrocyte development and myelination. Glia (Aug).
- Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ, D. (2021) Calcineurin activity is increased in Charcot-Marie-Tooth 1B demyelinating neuropathy. The Journal of neuroscience : the official journal of the Society for Neuroscience (Apr).
- Wan R, Cheli VT, Santiago-González DA, Rosenblum SL, Wan Q, Paez PM. (2020) Impaired postnatal myelination in a conditional knock-out mouse for the ferritin heavy chain in oligodendroglial cells. J Neurosci (Aug).
- Zamora NN, Cheli VT, SantiagoGonzález DA, Wan R, Paez PM. (2020) Deletion of voltage-gated calcium channels in astrocytes during demyelination reduces brain inflammation and promotes myelin regeneration in mice. J Neurosci (Mar).
- Paez PM, Lyons DA. (2020) Calcium Signaling in the Oligodendrocyte Lineage: Regulators and Consequences. Annu Rev Neurosci (Feb).
- Cheli VT, Correale J, Paez PM, Pasquini JM. (2020) Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination. ASN Neuro (Jan), 12: 1759091420-1759091420.
- Santiago González DA, Cheli VT, Wan R, Paez PM. (2019) Iron metabolism in the peripheral nervous system: the role of DMT1, ferritin and transferrin receptor in Schwann cell maturation and myelination. J Neurosci (Nov).
- Cheli VT, González Santiago DA, Marziali LN, Zamora NN, Guitart ME, Spreuer V, Pasquini JM, Paez PM. (2018) The Divalent Metal Transporter 1 (DMT1) is required for iron uptake and normal development of oligodendrocyte progenitor cells. J Neurosci (Sep).
- Cheli VT, Santiago González DA, Zamora NN, Lama TN, Spreuer V, Rasmusson RL, Bett GC, Panagiotakos G, Paez PM. (2018) Enhanced oligodendrocyte maturation and myelination in a mouse model of Timothy syndrome. Glia (Aug).
- Siemian JN, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li JX. (2018) The imidazoline I2 receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochemical pharmacology (Jul), 153: 260-268. doi:10.1016/j.bcp.2018.01.032
- Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O‘Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ. (2018) Muscarinic receptor M3R signaling prevents efficient remyelination by human and mouse oligodendrocyte progenitor cells. J Neurosci (Jun).
- Santiago González DA, Cheli VT, Zamora NN, Lama TN, Spreuer V, Murphy GG, Paez PM. (2017) Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice. J Neurosci (Oct), 37(42): 10038-10051.
- Cheli VT, Santiago González DA, Spreuer V, Handley V, Campagnoni AT, Paez PM. (2017) Erratum to: Golli Myelin Basic Proteins Modulate Voltage-Operated Ca++ Influx and Development in Cortical and Hippocampal Neurons. Molecular neurobiology (Jan), 54(1): 817.
- Cheli VT, Santiago González DA, Namgyal Lama T, Spreuer V, Handley V, Murphy GG, Paez PM. (2016) Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice. J Neurosci (Oct), 36(42): 10853-10869.
- Cheli VT, Santiago González DA, Smith J, Spreuer V, Murphy GG, Paez PM. (2016) L-type voltage-operated calcium channels contribute to astrocyte activation In vitro. Glia (Jun).
- Guardia Clausi M, Paez PM, Pasquini LA, Pasquini JM. (2016) Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain. Pharmacol Res (Jan).
- Levine J, Kwon E, Paez P, Yan W, Czerwieniec G, Loo JA, Sofroniew MV, Wanner IB, Paez PM. (2015) Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival. Glia (Dec).
- Cheli VT,Santiago-Gonzalez DA, Spreuer V,Handley V, Campagnoni AT, Paez PM. (2015) Golli Myelin Basic Proteins Modulate Voltage-Operated Ca++ Influx and Development in Cortical and Hippocampal Neurons. Mol Neurobiol (Oct).
- Cheli VT, Santiago González DA, Spreuer V, Paez PM. (2015) Voltage-gated Ca2+ entry promotes oligodendrocyte progenitor cell maturation and myelination in vitro. Exp Neurol (Mar), 265: 69-83.
- Espinosa-Jeffrey A, Paez PM, Cheli VT, Spreuer V, Wanner I, de Vellis J. (2013) Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repair. PLoS One (Dec), 8(12): 76963-76963.
- Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA. (2012) STAT3-Mediated astrogliosis protects myelin development in neonatal brain injury. Ann Neurol (Nov), 72(5): 750-765.
- Guardia Clausi M, Paez PM, Campagnoni AT, Pasquini LA, Pasquini JM. (2012) Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event. Glia (Oct), 60(10): 1540-1554.
- Paez PM, Cheli VT, Ghiani CA, Spreuer V, Handley VW, Campagnoni AT. (2012) Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain. Glia (Jul), 60(7): 1078-1093.
- Smith GS, De Avila M, Paez PM, Spreuer V, Wills MK, Jones N, Boggs JM, Harauz G. (2012) Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes. J Neurosci Res (Jan), 90(1): 28-47.
- Fulton D, Paez P, Spreur V, Handley V, Colwell CS, Campagnoni A, Fisher R, Paez PM. (2011) Developmental activation of the proteolipid protein promoter transgene in neuronal and oligodendroglial cells of neostriatum in mice. Dev Neurosci (Sep), 33(2): 170-184.
- Smith GS, Paez PM, Spreuer V, Campagnoni CW, Boggs JM, Campagnoni AT, Harauz G. (2011) Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms. J Neurosci Res (Apr), 89(4): 467-480.
- Paez PM, Fulton D, Spreuer V, Handley V, Campagnoni AT. (2011) Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene. J Neurosci (Mar), 31(10): 3625-3637.
- Fulton D, Paez PM, Fisher R, Handley V, Colwell CS, Campagnoni AT. (2010) Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins. Glia (Aug), 58(11): 1292-1303.
- Paez PM, Fulton DJ, Spreur V, Handley V, Campagnoni AT. (2010) Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells. J Neurosci (May), 30(18): 6422-6433.
- Fulton D, Paez PM, Campagnoni AT. (2010) The multiple roles of myelin protein genes during the development of the oligodendrocyte. ASN Neuro (Feb), 2(1): 00027-00027.
- Mendeluk GR, Sardi-Segovia LM, Chenlo PH, Pugliese MN, Repetto H, Curi S, Ariagno J, Prentki Santos E, Paez PM, Passanante EG, Palaoro LA. (2009) Assessment of human sperm protein tyrosine phosphorylation by immunocytochemistry in a clinical andrology laboratory. Biotech Histochem (Dec), 84(6): 321-328.
- Paez PM, Fulton D, Colwell CS, Campagnoni AT. (2009) Voltage-operated Ca(2+) and Na(+) channels in the oligodendrocyte lineage. J Neurosci Res (Nov), 87(15): 3259-3266.
- Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW, Macklin WB, Colwell C, Campagnoni AT. (2009) Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. J Neurosci (May), 29(20): 6663-6676.
- Todorich B, Pasquini JM, Garcia CI, Paez PM, Connor JR. (2009) Oligodendrocytes and myelination: the role of iron. Glia (Apr), 57(5): 467-478.
- Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW, Campagnoni AT. (2009) Regulation of store-operated and voltage-operated Ca2+ channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins. ASN Neuro (Apr), 1(1).
- Calatayud CA, García CI, Paez PM, Pasquini JM, Soto EF, Pasquini LA. (2009) Partial inhibition of the proteasome enhances the activity of the myelin basic protein promoter. Dev Neurosci (Jan), 31(3): 169-180.
- Paez PM, Spreuer V, Handley V, Feng JM, Campagnoni C, Campagnoni AT. (2007) Increased expression of golli myelin basic proteins enhances calcium influx into oligodendroglial cells. J Neurosci (Nov), 27(46): 12690-12699.
- García CI, Paez PM, Soto EF, Pasquini JM. (2007) Differential gene expression during development in two oligodendroglial cell lines overexpressing transferrin: a cDNA array analysis. Dev Neurosci (Jan), 29(6): 413-426.
- Paez PM, Garcia CI, Soto EF, Pasquini JM. (2006) Apotransferrin decreases the response of oligodendrocyte progenitors to PDGF and inhibits the progression of the cell cycle. Neurochem Int (Sep), 49(4): 359-371.
- Adamo AM, Paez PM, Escobar Cabrera OE, Wolfson M, Franco PG, Pasquini JM, Soto EF. (2006) Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin. Exp Neurol (Apr), 198(2): 519-529.
- Paez PM, García CI, Pasquini JM. (2006) Expression of myelin basic protein in two oligodendroglial cell lines is modulated by apotransferrin through different transcription factors. J Neurosci Res (Mar), 83(4): 606-618.
- Paez PM, García CI, Campagnoni AT, Soto EF, Pasquini JM. (2005) Overexpression of human transferrin in two oligodendroglial cell lines enhances their differentiation. Glia (Oct), 52(1): 1-15.
- Garcia C, Paez P, Davio C, Soto EF, Pasquini JM. (2004) Apotransferrin induces cAMP/CREB pathway and cell cycle exit in immature oligodendroglial cells. J Neurosci Res (Nov), 78(3): 338-346.
- Paez PM, García CI, Davio C, Campagnoni AT, Soto EF, Pasquini JM. (2004) Apotransferrin promotes the differentiation of two oligodendroglial cell lines. Glia (Apr), 46(2): 207-217.
- García CI, Paez P, Soto EF, Pasquini JM. (2003) Differential effects of apotransferrin on two populations of oligodendroglial cells. Glia (Jun), 42(4): 406-416.
- Pasquini LA, Paez PM, Moreno MA, Pasquini JM, Soto EF. (2003) Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation. J Neurosci (Jun), 23(11): 4635-4644.
- Marta CB, Paez P, Lopez M, Pellegrino de Iraldi A, Soto EF, Pasquini JM. (2003) Morphological changes of myelin sheaths in rats intracranially injected with apotransferrin. Neurochem Res (Jan), 28(1): 101-110.
- Paez PM, Marta CB, Moreno MB, Soto EF, Pasquini JM. (2002) Apotransferrin decreases migration and enhances differentiation of oligodendroglial progenitor cells in an in vitro system. Dev Neurosci (Jan), 24(1): 47-58.
Professional Memberships:
- American Society for Neurochemistry, Council Member (2021–present)
- American Society for Neurochemistry, Member of the Marian Kies Award Committee (2015–present)
- American Society for Pharmacology and Experimental Therapeutics (2013–present)
- International Society for Neurochemistry (2007–present)
- Society for Neuroscience (2006–present)
- American Society for Neurochemistry (2001–present)
Presentations:
- "Modulation of oligodendrocyte development by voltage-operated calcium channels" McGill University, Killam Seminar Series and Neuro Lectures (2022)
- "Modulation of oligodendrocyte development by voltage-operated calcium channels" University of California at Riverside, Division of Biomedical Sciences Seminar Series (2021)
- "Iron metabolism in oligodendrocytes and astrocytes, implications for myelination and remyelination" Annual Meeting of the American Society for Neurochemistry (2021)
- "The role of voltage-gated Ca++ channels in oligodendrocyte-neuronal interactions" University at Buffalo, Developmental Genomics Group Seminar Series (2020)
- "Voltage-gated calcium channels in reactive astrocytes, a possible therapeutic target to reduce brain inflammation and promote remyelination in Multiple Sclerosis" University of Buenos Aires, School of Pharmacy and Biochemistry Seminar Series (2020)
- "The function of DMT1, ferritin and transferrin receptor in myelination and remyelination" Annual Meeting of the American Society for Neurochemistry (2020)
- "Selective deletion of voltage-gated Ca++ channels in reactive astrocytes attenuate astrogliosis and promote myelin regeneration after demyelination of the mouse brain" University at Buffalo, Developmental Genomics Group Seminar Series (2019)
- "The role of voltage-gated calcium channels in oligodendrocyte development and myelination" Biennial International Society for Neurochemistry Satellite Meeting on Myelin Biology (2019)
- "Voltage-gated calcium channels in reactive astrocytes, a possible therapeutic target to reduce brain inflammation and promote remyelination in Multiple Sclerosis" Nantong University, International Academic Forum on Neuroinflammation and Psychopharmacology (2019)
- "The role of voltage-gated calcium channels in oligodendrocyte development and myelination" CUNY, Advanced Science Research Center, Second Annual Glial Symposium (2018)
- "The function of glial calcium channels in the development of the central nervous system" Latin American School on Glial Cells, International Brain Research Organization (2017)
- "The role of voltage-gated calcium channels in oligodendrocyte development and myelination" Virginia Commonwealth University, Department of Anatomy and Neurobiology Seminar Series (2017)
- "The Divalent Metal Transporter 1 (DMT1) is required for adequate oligodendrocyte progenitor cell maturation and myelination" University at Buffalo, Developmental Genomics Group Seminar Series (2017)
- "Voltage-gated ion channels and the myelination of the postnatal brain" University of Buenos Aires, School of Pharmacy and Biochemistry Seminar Series (2017)
- "A role for voltage-operated calcium channels in astrocyte activation" University at Buffalo, Developmental Genomics Group Seminar Series (2015)
- "A role for voltage-operated calcium channels in the development of oligodendrocytes" University at Buffalo, Department of Neurology Seminar Series (2014)
- "The role of golli-mbp in the development of the central nervous system" University at Buffalo, Developmental Genomics Group Seminar Series (2014)
- "The role of voltage-operated calcium channels in the myelination of the postnatal brain" McMaster University, Department of Psychology, Neuroscience and Behavior (2014)
- "Conditional deletion of the L-type calcium channel Cav1.2 in oligodendrocyte progenitor cells delay postnatal myelination in mice" University at Buffalo, Developmental Genomics Group Seminar Series (2013)
- "Conditional deletion of the L-type calcium channel Cav1.2 in oligodendrocyte progenitor cells delay postnatal myelination in mice" University at Buffalo, Department of Pharmacology and Toxicology Seminar Series (2013)
- "Modulation of oligodendrocyte function and myelination by the golli proteins" Annual National Multiple Sclerosis Society Research Forum (2011)
- "The function of golli proteins in myelination and remyelination" Annual Meeting of the American Society for Neurochemistry (2011)
- "Molecular regulation of oligodendrocyte developmen" Annual Meeting of the American Society for Neurochemistry (2009)
- "Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca++ influx" University of California at Los Angeles, Department of Neurobiology Seminar Series (2009)
- "The role of golli proteins in oligodendrocyte development" University of California at Los Angeles, Mental Retardation Research Center Annual Retreat (2008)
- "The overexpression of human transferrin enhances the differentiation of two oligodendroglial cell lines" Annual Meeting of the Argentine Society for Neurochemistry, Young Investigator Lecture (2005)
Service Activities:
- Member of the Search Committee for the New Dean of the School of Pharmacy and Pharmaceutical Sciences, University at Buffalo (2020–2021)
- Member of the Committee on Promotions to Academic (Tenurial) Rank, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (2020–present)
- National Institute of Neurological Disorders and Stroke (NINDS), regular member of the Cellular and Molecular Biology of Glia Study Section; Grant Reviewer (2018–present)
- Member of the Faculty Council, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (2016–present)
- ASN Neuro; ASN Neuro (Editorial Board Member) (2015–present)
- Brain Research; Manuscript Reviewer (2015–present)
- BMC Biology; Manuscript Reviewer (2015–present)
- Communications Biology; Manuscript Reviewer (2015–present)
- Developmental Biology; Manuscript Reviewer (2015–present)
- Developmental Neuroscience; Manuscript Reviewer (2015–present)
- Glia; Manuscript Reviewer (2015–present)
- International Journal of Developmental Neuroscience; Manuscript Reviewer (2015–present)
- Journal of Neuroscience; Manuscript Reviewer (2015–present)
- Journal of Neuroscience Research; Manuscript Reviewer (2015–present)
- Journal of Neuroinflammation; Manuscript Reviewer (2015–present)
- Journal of Toxicology and Environmental Health; Manuscript Reviewer (2015–present)
- Molecular Neurobiology; Manuscript Reviewer (2015–present)
- Neurobiology of Disease; Manuscript Reviewer (2015–present)
- Neuropharmacology; Manuscript Reviewer (2015–present)
- Neuroscience Bulletin; Manuscript Reviewer (2015–present)
- Stem Cell Research and Therapy; Manuscript Reviewer (2015–present)
- National Multiple Sclerosis Society, Biomedical Review Committee; Grant Reviewer (2015–present)
- Member of the Graduate Student Educational Committee, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo; Member of the Graduate Student Educational Committee (2014–2016)
- Member of the Developmental Genomics Group, Western New York Stem Cell Culture and Analysis Center (WNYSTEM) (2013–present)
- Member of the Graduate Student Admission Committee, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo; Member of the Graduate Student Admission Committee (2013–present)
- National Multiple Sclerosis Society, Pilot Glial Committee; Grant Reviewer (2010–2015)