M. Jeffery Mador MD

M. Jeffery Mador

M. Jeffery Mador

Associate Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Pulmonary & Critical Care Medicine; Sleep Medicine

Contact Information
Veterans Hospital
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-8634

Patient Care

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD

Professional Summary:

My patient care responsibilities are centered at the Veterans Administration Western New York Healthcare System (VA) where I care for hospitalized patients with pulmonary problems as well as maintain two active outpatient clinics in the VA system: the pulmonary clinic and the sleep medicine clinic. I also supervise the continuity clinics at the VA.

My research interests dovetail with my clinical work. I conduct research on skeletal muscle function in patients with chronic obstructive pulmonary disease (COPD) and those patients in pulmonary rehabilitation. I investigate predictors of the response to pulmonary rehabilitation, and I am also interested in sleep apnea research, comparing the occurrence of complications (postoperative and others) between patients with sleep apnea and those without. I examine sleep apnea treatment options and their success rate in special patient populations, such as patients with psychiatric disease or those on chronic opioid therapy.

I run multicenter trials in patients with COPD, and I am presently involved in two NIH-sponsored studies: one examining the effects of long-term oxygen therapy in patients with mild hypoxemia and one examining whether administration of a statin can reduce the exacerbation rate in optimally-treated patients with COPD.

I teach medical students primarily in the respiratory physiology course. I enjoy working with students throughout the full spectrum of medical education from first-year medical students to senior fellows in pulmonary critical care or sleep medicine. As the fellowship director for pulmonary critical care medicine I am responsible for the educational curricula for the fellowship.

Education and Training:

  • Residency, University of Toronto (1984)
  • MD, Medicine, University of Toronto (1981)


  • Director, Pulmonary Critical Care Fellowship, Pulmonary & Critical Care, University at Buffalo (2004-present)
  • Associate Professor, Medicine, University at Buffalo (1994-present)
  • Staff Physician, VAMC (1987-present)
  • Director, Medical Intensive Care Unit, VAMC
  • Director, Sleep Laboratory, VAMC (1997–2011)
  • Associate Director, Pulmonary Critical Care Fellowship, Medicine (2001–2004)
  • Attending Physician, Sister's of Charity Hospital (1996–2001)
  • Assistant Professor, Medicine, University at Buffalo (1987–1994)
  • Fellow, Pulmonary Critical Care, University of Texas at Houston (1984–1987)

Awards and Honors:

  • Alpha Omega Alpha Honor Medical Society (1980)
  • CD Wainwright Scholarship (1978)
  • Ann Shepard Memorial Scholarship (1976)

Research Expertise:

  • Assessment of respiratory muscle function
  • Clinical implications of sleep apnea
  • New therapeutics in COPD
  • Outcomes of pulmonary rehabilitation

Grants and Sponsored Research:

  • February 2014–February 2017
    A Clinical Outcomes Study to Compare the Effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25MCG with Placebo on Survival in Subjects with Moderate Chronic Obstructive Pulmonary Disease (COPD) and a History of or at Increased Risk for Cardio
    Role: Principal Investigator
  • November 2013–December 2016
    Double-blind, Randomized, Placebo-Controlled, Parallel-Group, Phase IV Study to Evaluate the Effect of Acidinium Bromide on Long-Tern Cardiovascular Safety and COPD Exacerbations in Patients with Moderate to Very Severe COPD (Ascent)
    Role: Principal Investigator
  • February 2011–March 2016
    LOTT study
    Role: Co-Investigator
  • February 2011–March 2014
    Role: Co-Investigator
  • April 2011–March 2012
    A prospective observational study to evaluate biomarkers in acute exacerbations in chronic obstructive pulmonary disease
    Role: Co-Investigator
  • December 2006–December 2010
    Bronchitis and emphysema advice and training to reduce hospitalization (BREATH): A randomized controlled trial of disease management to prevent COPD hospitalizations. VA cooperative study site investigator.
    Role: Principal Investigator
  • January 2003–December 2004
    The effect of emphysema and exercise training on limb muscle function in the hamster.
    VA Research
    Role: Co-Investigator
  • January 2001–June 2003
    Randomized clinical study to mesaure relative responsiveness and validity of various health related quality of life indices in patients with chronic respiratory diseases
    McMaster University
    Role: Co-Investigator
  • October 1993–September 1996
    Peripheral and central components of diaphragmatic fatique
    VA Merit Review
    Role: Co-Investigator
  • October 1988–September 1990
    Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in congestive heart failure
    American Heart Association of New York
    Role: Co-Investigator
  • July 1988–June 1990
    Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in interstitial lung disease
    American Lung Association of New York
    Role: Co-Investigator
  • April 1988–March 1990
    Vagal Influences on ventilatory control in interstitial lung disease
    VAMC Research Advisory Group
    Role: Co-Investigator
  • February 1988–January 1990
    Effect of pulmonary neuroreceptor blockade on ventilatory control and dyspnea in interstitial lung disease
    Resarch & Development/BRSG Award
    Role: Co-Investigator
See all (3 more)

Journal Articles:

See all (82 more)

Books and Book Chapters:

  • Mogri M., Mador MJ. Mechanical Ventilation of the Obese Patient. 2013.
  • Mador MJ, Gibbons WJ. Invasive ventilation and the intensive care unit. Chapter in: Cronic Obstructive Pulmonary Disease, 2nd ed. Editors: P Calcerley & N Pride. Arnold Publishers, London, UK. 2003.
  • Magalang UJ, Mador MJ. Behavioral and pharmacologic therapy of obstructive sleep apnea. Chapter in: Sleep Medicine. Editors: Lee-Choing, TL, Carskadon, MA, Sateia, MJ. Hanley & Belfus, Inc. Philadelphia, PA.. 2002.
  • Mador MJ, Tobin, MJ. Acute respiratory failure. Chapter in:Chronic obstructive pulmonary diseases. Editors: Calverley, PMA, Pride, NB. Chapman & Hall: London.. 1995.
  • Mador M. Assist-control ventilation. Chapter in: Principles and practice of mechanical ventilation. Editor: MJ Tobin. McGraw-Hill, NY.. 1994.
  • Mador MJ, Walsh, JM, Tobin, MJ. Work of breathing and respiratory muscle function. Chapter in: Monitoring in Respiratory Care. Editors: Kacmarek, RM, Hess, D, Stoller, JK. Mosby-Year Book, Inc.. 1993.
  • Mador M. Respiratory muscle pharmacotherapy, Chapter in: Problems in Respiratory Care; the respiratory muscles. MJ Tobin, editor. J.B. Lippincott: Philadelphia,. 1990; 3(3).
  • Tobin, MJ, Yang, KL, Mador MJ. Variability of breathing pattern. Chapter in: Sleep and Health Risks. Editors: Peter, JH, Podszus, T., von Wiechert, P. Springer-Verlag-Berlin. 1990.
  • Mador MJ, Shetty M.. Prevalence of positional obstructive sleep apnea in patients undergoing polysomnography and the effect of sleep stage. (in press)..


  • Dy R., Mador MJ. Dynamic arterial waveform changes as predictors of fluid responsiveness in intensive care unit patients: A systematic review and meta-analysis. American Thoracic Society. 2016.
  • Mador M. A PET artifact masquerading as a PET positive lung mass. American Thoracic Society. 2016.
  • Metta VVSR., Zaka A., Lee V., Mador MJ. Positive airway pressure adherence in patients with obstructive sleep apnea and symptomatic BPH. Sleep. 2015; a856(APSS).
  • Metta VVSR., Patel S.M., Singh S., Mador MJ. Positive Airway Pressure Adherence in Patients with Obstructive Sleep Apnea with Depression or Anxiety. Sleep. 2015; A485(APSS).
  • Mador M. Efficacy of Bronchoscopic Lung Volume Reduction: Meta Analysis. American Thoracic Society. 2015; 66550.
  • Kumar A., Mador MJ. Nodular cystic pulmonary disease in a non smoker. American Thoracic Society. 2015; A1409.
  • Gassam S., Gunukula S.K., Mador MJ. Post-operative outcomes in adult obstructive sleep apnea patients undergoing non-upper airway surgery: A systematic review and meta-analysis. Am J Respir Crit Care Med. 2013; 187(A5950).
  • Mogri M., Patel A., Mador MJ. Contractile fatigue of the quadriceps muscle predicts improvement in exercise performance after pulmonary rehabilitation. Am J Respir Crit Care Med. 2012; 185(A3673).
  • Mador MJ, Nadler JN, Khadka G., Gottumukkala V.A., Abo-Khamis M., Mehboob S.. Do patients at risk of obstructive sleep apnea have an increased risk of cardiorespiratory complications during endoscopy procedures?. Am J Respir Crit Care Med. 2010; 181(A3679).
  • El Solh AA, Mador MJ, Ten Brock E, Shucard D, Grant BJ. Validity of an artificial neural network in predicting sleep apnea. (abstract). Am J Respir Crit Care Med. 1998; 157(A852).

Evaluative Studies and Case Reports:

Professional Memberships:

  • Member, College of Physicians and Surgeons of Ontario
  • Member/American Thoracic Society
  • Fellow - American College of Chest Physicians


  • "Postoperative and endoscopy complications and sleep apnea" American Thoracic Society 2015 (2015)

Service Activities:

  • Manuscript reviewer/Am. J. of Respir. & Critical Care Med.; Reviewer
  • Manuscript reviewer/Chest; Reviewer
  • Manuscript reviewer/European Journal of Applied Physiology; Reviewer
  • Manuscript reviewer/European Respiratory Journal; Reviewer
  • Manuscript reviewer/J. of Applied Physiology; Panel Member
  • Manuscript reviewer/Medicine in Sports and Exercise Science; Reviewer
  • Manuscript reviewer/Respiration Physiology; Reviewer
  • Manuscript reviewer/Thorax; Reviewer

School News:

In the Media:

Clinical Specialties:

Clinical Offices:

Insurance Accepted:

Contact Information

Veterans Hospital
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-8634

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD