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M. Jeffery                     Mador

M. Jeffery Mador MD

Department of Medicine

Associate Professor

Specialty/Research Focus

Pulmonary & Critical Care Medicine; Sleep Medicine

Professional Summary:

My patient care responsibilities are centered at the Veterans Administration Western New York Healthcare System (VA) where I care for hospitalized patients with pulmonary problems as well as maintain two active outpatient clinics in the VA system: the pulmonary clinic and the sleep medicine clinic. I also supervise the continuity clinics at the VA.

My research interests dovetail with my clinical work. I conduct research on skeletal muscle function in patients with chronic obstructive pulmonary disease (COPD) and those patients in pulmonary rehabilitation. I investigate predictors of the response to pulmonary rehabilitation, and I am also interested in sleep apnea research, comparing the occurrence of complications (postoperative and others) between patients with sleep apnea and those without. I examine sleep apnea treatment options and their success rate in special patient populations, such as patients with psychiatric disease or those on chronic opioid therapy.

I run multicenter trials in patients with COPD, and I am presently involved in two NIH-sponsored studies: one examining the effects of long-term oxygen therapy in patients with mild hypoxemia and one examining whether administration of a statin can reduce the exacerbation rate in optimally-treated patients with COPD.

I teach medical students primarily in the respiratory physiology course. I enjoy working with students throughout the full spectrum of medical education from first-year medical students to senior fellows in pulmonary critical care or sleep medicine. As the fellowship director for pulmonary critical care medicine I am responsible for the educational curricula for the fellowship.

Education and Training:
  • Residency, University of Toronto (1984)
  • MD, Medicine, University of Toronto (1981)
  • Director, Pulmonary Critical Care Fellowship, Pulmonary & Critical Care, University at Buffalo (2004-present)
  • Associate Professor, Medicine, University at Buffalo (1994-present)
  • Staff Physician, VAMC (1987-present)
  • Director, Medical Intensive Care Unit, VAMC
  • Director, Sleep Laboratory, VAMC (1997–2011)
  • Associate Director, Pulmonary Critical Care Fellowship, Medicine (2001–2004)
  • Attending Physician, Sister's of Charity Hospital (1996–2001)
  • Assistant Professor, Medicine, University at Buffalo (1987–1994)
  • Fellow, Pulmonary Critical Care, University of Texas at Houston (1984–1987)
Awards and Honors:
  • Alpha Omega Alpha Honor Medical Society (1980)
  • CD Wainwright Scholarship (1978)
  • Ann Shepard Memorial Scholarship (1976)

Research Expertise:
  • Assessment of respiratory muscle function
  • Clinical implications of sleep apnea
  • New therapeutics in COPD
  • Outcomes of pulmonary rehabilitation
Grants and Sponsored Research:
  • February 2014–February 2017
    A Clinical Outcomes Study to Compare the Effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25MCG with Placebo on Survival in Subjects with Moderate Chronic Obstructive Pulmonary Disease (COPD) and a History of or at Increased Risk for Cardio
    Role: Principal Investigator
  • November 2013–December 2016
    Double-blind, Randomized, Placebo-Controlled, Parallel-Group, Phase IV Study to Evaluate the Effect of Acidinium Bromide on Long-Tern Cardiovascular Safety and COPD Exacerbations in Patients with Moderate to Very Severe COPD (Ascent)
    Role: Principal Investigator
  • February 2011–March 2016
    LOTT study
    Role: Co-Investigator
  • February 2011–March 2014
    Role: Co-Investigator
  • April 2011–March 2012
    A prospective observational study to evaluate biomarkers in acute exacerbations in chronic obstructive pulmonary disease
    Role: Co-Investigator
  • December 2006–December 2010
    Bronchitis and emphysema advice and training to reduce hospitalization (BREATH): A randomized controlled trial of disease management to prevent COPD hospitalizations. VA cooperative study site investigator.
    Role: Principal Investigator
  • January 2003–December 2004
    The effect of emphysema and exercise training on limb muscle function in the hamster.
    VA Research
    Role: Co-Investigator
  • January 2001–June 2003
    Randomized clinical study to mesaure relative responsiveness and validity of various health related quality of life indices in patients with chronic respiratory diseases
    McMaster University
    Role: Co-Investigator
  • October 1993–September 1996
    Peripheral and central components of diaphragmatic fatique
    VA Merit Review
    Role: Co-Investigator
  • October 1988–September 1990
    Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in congestive heart failure
    American Heart Association of New York
    Role: Co-Investigator
  • July 1988–June 1990
    Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in interstitial lung disease
    American Lung Association of New York
    Role: Co-Investigator
  • April 1988–March 1990
    Vagal Influences on ventilatory control in interstitial lung disease
    VAMC Research Advisory Group
    Role: Co-Investigator
  • February 1988–January 1990
    Effect of pulmonary neuroreceptor blockade on ventilatory control and dyspnea in interstitial lung disease
    Resarch & Development/BRSG Award
    Role: Co-Investigator
See all (3 more)

Evaluative Studies and Case Reports:
Journal Articles:
See all (82 more)
  • Dy R., Mador MJ. Dynamic arterial waveform changes as predictors of fluid responsiveness in intensive care unit patients: A systematic review and meta-analysis. American Thoracic Society. 2016.
  • Mador M. A PET artifact masquerading as a PET positive lung mass. American Thoracic Society. 2016.
  • Metta VVSR., Zaka A., Lee V., Mador MJ. Positive airway pressure adherence in patients with obstructive sleep apnea and symptomatic BPH. Sleep. 2015; a856(APSS).
  • Metta VVSR., Patel S.M., Singh S., Mador MJ. Positive Airway Pressure Adherence in Patients with Obstructive Sleep Apnea with Depression or Anxiety. Sleep. 2015; A485(APSS).
  • Mador M. Efficacy of Bronchoscopic Lung Volume Reduction: Meta Analysis. American Thoracic Society. 2015; 66550.
  • Kumar A., Mador MJ. Nodular cystic pulmonary disease in a non smoker. American Thoracic Society. 2015; A1409.
  • Gassam S., Gunukula S.K., Mador MJ. Post-operative outcomes in adult obstructive sleep apnea patients undergoing non-upper airway surgery: A systematic review and meta-analysis. Am J Respir Crit Care Med. 2013; 187(A5950).
  • Mogri M., Patel A., Mador MJ. Contractile fatigue of the quadriceps muscle predicts improvement in exercise performance after pulmonary rehabilitation. Am J Respir Crit Care Med. 2012; 185(A3673).
  • Mador MJ, Nadler JN, Khadka G., Gottumukkala V.A., Abo-Khamis M., Mehboob S.. Do patients at risk of obstructive sleep apnea have an increased risk of cardiorespiratory complications during endoscopy procedures?. Am J Respir Crit Care Med. 2010; 181(A3679).
  • El Solh AA, Mador MJ, Ten Brock E, Shucard D, Grant BJ. Validity of an artificial neural network in predicting sleep apnea. (abstract). Am J Respir Crit Care Med. 1998; 157(A852).
Books and Book Chapters:
  • Mogri M., Mador MJ. Mechanical Ventilation of the Obese Patient. 2013.
  • Mador MJ, Gibbons WJ. Invasive ventilation and the intensive care unit. Chapter in: Cronic Obstructive Pulmonary Disease, 2nd ed. Editors: P Calcerley & N Pride. Arnold Publishers, London, UK. 2003.
  • Magalang UJ, Mador MJ. Behavioral and pharmacologic therapy of obstructive sleep apnea. Chapter in: Sleep Medicine. Editors: Lee-Choing, TL, Carskadon, MA, Sateia, MJ. Hanley & Belfus, Inc. Philadelphia, PA.. 2002.
  • Mador MJ, Tobin, MJ. Acute respiratory failure. Chapter in:Chronic obstructive pulmonary diseases. Editors: Calverley, PMA, Pride, NB. Chapman & Hall: London.. 1995.
  • Mador M. Assist-control ventilation. Chapter in: Principles and practice of mechanical ventilation. Editor: MJ Tobin. McGraw-Hill, NY.. 1994.
  • Mador MJ, Walsh, JM, Tobin, MJ. Work of breathing and respiratory muscle function. Chapter in: Monitoring in Respiratory Care. Editors: Kacmarek, RM, Hess, D, Stoller, JK. Mosby-Year Book, Inc.. 1993.
  • Mador M. Respiratory muscle pharmacotherapy, Chapter in: Problems in Respiratory Care; the respiratory muscles. MJ Tobin, editor. J.B. Lippincott: Philadelphia,. 1990; 3(3).
  • Tobin, MJ, Yang, KL, Mador MJ. Variability of breathing pattern. Chapter in: Sleep and Health Risks. Editors: Peter, JH, Podszus, T., von Wiechert, P. Springer-Verlag-Berlin. 1990.
  • Mador MJ, Shetty M.. Prevalence of positional obstructive sleep apnea in patients undergoing polysomnography and the effect of sleep stage. (in press)..

Professional Memberships:
  • Member, College of Physicians and Surgeons of Ontario
  • Member/American Thoracic Society
  • Fellow - American College of Chest Physicians
  • "Postoperative and endoscopy complications and sleep apnea" American Thoracic Society 2015 (2015)
Service Activities:
  • Manuscript reviewer/Am. J. of Respir. & Critical Care Med.; Reviewer
  • Manuscript reviewer/Chest; Reviewer
  • Manuscript reviewer/European Journal of Applied Physiology; Reviewer
  • Manuscript reviewer/European Respiratory Journal; Reviewer
  • Manuscript reviewer/J. of Applied Physiology; Panel Member
  • Manuscript reviewer/Medicine in Sports and Exercise Science; Reviewer
  • Manuscript reviewer/Respiration Physiology; Reviewer
  • Manuscript reviewer/Thorax; Reviewer

School News:
In the Media:

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Contact Information

Veterans Hospital
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-8634

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