My patient care responsibilities are centered at the Veterans Administration Western New York Healthcare System (VA) where I care for hospitalized patients with pulmonary problems as well as maintain two active outpatient clinics in the VA system: the pulmonary clinic and the sleep medicine clinic. I also supervise the continuity clinics at the VA.
My research interests dovetail with my clinical work. I conduct research on skeletal muscle function in patients with chronic obstructive pulmonary disease (COPD) and those patients in pulmonary rehabilitation. I investigate predictors of the response to pulmonary rehabilitation, and I am also interested in sleep apnea research, comparing the occurrence of complications (postoperative and others) between patients with sleep apnea and those without. I examine sleep apnea treatment options and their success rate in special patient populations, such as patients with psychiatric disease or those on chronic opioid therapy.
I run multicenter trials in patients with COPD, and I am presently involved in two NIH-sponsored studies: one examining the effects of long-term oxygen therapy in patients with mild hypoxemia and one examining whether administration of a statin can reduce the exacerbation rate in optimally-treated patients with COPD.
I teach medical students primarily in the respiratory physiology course. I enjoy working with students throughout the full spectrum of medical education from first-year medical students to senior fellows in pulmonary critical care or sleep medicine. As the fellowship director for pulmonary critical care medicine I am responsible for the educational curricula for the fellowship.
Education and Training:
MD, Medicine, University of Toronto (1981)
Employment:
Director, Pulmonary Critical Care Fellowship, Pulmonary & Critical Care, University at Buffalo (2004-present)
Associate Professor, University at Buffalo (1994-present)
Associate Director, Pulmonary Critical Care Fellowship (2001–2004)
Attending Physician, Sister's of Charity Hospital (1996–2001)
Director, Medical Intensive Care Unit, Medical Intensive Care Unit, VAMC (1993–1999)
Assistant Professor, University at Buffalo (1987–1994)
Fellow, Pulmonary Critical Care, University of Texas at Houston (1984–1987)
Internal medicine resident, University of Toronto, University of Toronto, Canada (1981–1984)
Awards and Honors:
Alpha Omega Alpha Honor Medical Society (1980)
CD Wainwright Scholarship (1978)
Ann Shepard Memorial Scholarship (1976)
Grants and Sponsored Research:
December 2006–December 2110 Bronchitis and emphysema advice and training to reduce hospitalization (BREATH): A randomized ,controlled trial of disease management to prevent COPD hospitalizations. VA cooperative study,site investigator. Role: Principal Investigator $2,428,742
February 2011–December 2014 LOTT study NIH Role: Co-Investigator $128,800
February 2011–December 2012 Statcope NIH Role: Co-Investigator $78,616
April 2011–March 2012 A prospective observational study to evaluate biomarkers in acute exacerbations in chronic obstructive pulmonary disease Medimmune Role: Co-Investigator $9,375
January 2003–December 2004 The effect of emphysema and exercise training on limb muscle function in the hamster. VA Research Role: Co-Investigator $30,000
January 2001–June 2003 Randomized clinical study to mesaure relative responsiveness and validity of various health related quality of life indices in patients with chronic respiratory diseases McMaster University Role: Co-Investigator $25,000
October 1993–September 1996 Peripheral and central components of diaphragmatic fatique VA Merit Review Role: Co-Investigator $175,600
October 1988–September 1990 Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in congestive heart failure American Heart Association of New York Role: Co-Investigator $48,992
July 1988–June 1990 Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in interstitial lung disease American Lung Association of New York Role: Co-Investigator $34,950
April 1988–March 1990 Vagal Influences on ventilatory control in interstitial lung disease VAMC Research Advisory Group Role: Co-Investigator $20,000
February 1988–January 1990 Effect of pulmonary neuroreceptor blockade on ventilatory control and dyspnea in interstitial lung disease Resarch & Development/BRSG Award Role: Co-Investigator $5,325
Mador MJ. A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations:a randomized controlled trial. ann intern med. 2012; 156.
Mador MJ, Goplani S., Gottumukkala V.A., El Solh AA, Akashdeep K, Khadka G, Abo Khamis M.. Postoperative complications in obstructive sleep apnea.. Sleep and Breathing. 2012.
Mador MJ, Nadler J, Patel, A.. The effects of pulmonary rehabilitation on activity levels in patients with COPD. Journal of Cardiopulm Rehab and Prev. 2011; 31.
Desai H., Patel A., Patel P., Grant BJ, Mador MJ. Accuracy of Auto-Titrating CPAP to Estimate the Residual Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea on Treatment with Auto-Titrating CPAP.. Sleep and Breathing. 2009; 13.
Desai H., Mador MJ. Sleep in patients with respiratory muscle weakness.. Sleep Medicine Clinics. 2008; 3.
Puhan M.A., Mador MJ, Held U., Goldstein R., Guyatt G.H., Schunemann H.J.. Interpretation of treatment changes in six-minute walk distance in patients with COPD. Eur Respiration Journal. 2008; 32.
Puhan M.A., Guyatt G.H., Goldstein R., Mador MJ, McKim D., Stahl E., Griffith L., Schunemann H.J.. Relative responsiveness of the chronic respiratory questionnaire, St Georges respiratory questionnaire and four other health related quality of life instruments for patients with chronic lung disease.. Respir Med. 2007; 101.
Waxmonsky J., Wood B.L., Stern T., Ballow M., Lillis K., Cramer-Benjamin D., Mador MJ, Miller B.D.. Association of depressive symptoms and disease activity in children with asthma: methodological and clinical implications.. J Am Acad Child Adolesc Psychiatry. 2006; 45.
Mador MJ, Denia O., Aggarwal A., Kufel T.J.. Quadriceps fatigability after single muscle exercise in patients with COPD.. Am J Respir Crit Care Med. 2003; 168.
Mador MJ, Bozkanat, E, Kufel TJ. Quadriceps fatigue after cycle exercise in patients with chronic obstructive pulmonary disease compared with healthy controls. Chest. 2003; 123.
El Solh AA, Mador MJ, Sikka P., Roth M., Dhillon RS, Grant BJ. Adhesion molecules in coronary artery disease patients with sleep apnea.. Chest. 2002; 121.
El Solh A, Bozkanat E., Mador M, Grant BJ. Association between plasma endothelin-1 levels and Cheynes–Stokes respiration in patients with congestive heart failure.. Chest. 2002; 121.
Mador MJ, Khan S., Kufel T.J.. Bilateral anterolateral magnetic stimulation of the phrenic nerves can detect diaphragmatic fatigue.. Chest. 2002; 121.
Kufel T.J., Pineda LA, Mador MJ. Comparison of potentiated and unpotentiated twitches as an index of contractile fatigue.. Muscle Nerve. 2002.
Kufel T.J., Pineda LA, Juneja R.G., Hathwar R, Mador MJ. Diaphragmatic fatigue after cycle exercise in patients with CHF.. Eur Respir J. 2002; 20.
Mador MJ, Kufel TJ, Pineda LA. Quadriceps fatigue following cycle exercise in patients with COPD. Am. J. Respir. Crit. Care Med.. 2000; 161.
Mador MJ, Kufel T.K., Pineda L.A.. Quadriceps and diaphragmatic function after exhaustive cycle exercise in the healthy elderly.. Am J Respir Crit Care Med. 2000; 162.
El Solh AA, Mador MJ, Tenbrock E, Shucard DW, Abul-Khoudoud, M, Grant BJ. Validity of an artificial neural network in predicting sleep apnea. Sleep. 1999; 22.
Mador MJ, Kufel, T.J.. Reproducibility of visual analog scale measurements of dyspnea in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1992; 146.
Mador MJ, Kufel T.J.. Effect of inspiratory muscle fatigue on inspiratory muscle relaxation rates in healthy subjects.. Chest. 1992; 102.
El Solh AA, Mador MJ, Ten Brock E, Shucard D, Grant BJ. Validity of an artificial neural network in predicting sleep apnea. (abstract). Am J Respir Crit Care Med. 1998; 157(A852).
Books and Book Chapters:
Mador MJ, Mogri M. Mechanical ventilation of the obese patient.. 2013.
Mador MJ, Gibbons WJ. Invasive ventilation and the intensive care unit. Chapter in: Cronic Obstructive Pulmonary Disease, 2nd ed. Editors: P Calcerley & N Pride. Arnold Publishers, London, UK. 2003.
Magalang UJ, Mador MJ. Behavioral and pharmacologic therapy of obstructive sleep apnea. Chapter in: Sleep Medicine. Editors: Lee-Choing, TL, Carskadon, MA, Sateia, MJ. Hanley & Belfus, Inc. Philadelphia, PA.. 2002.
Mador M. Assist-control ventilation. Chapter in: Principles and practice of mechanical ventilation. Editor: MJ Tobin. McGraw-Hill, NY.. 1994.
Mador MJ, Walsh, JM, Tobin, MJ. Work of breathing and respiratory muscle function. Chapter in: Monitoring in Respiratory Care. Editors: Kacmarek, RM, Hess, D, Stoller, JK. Mosby-Year Book, Inc.. 1993.
Mador M. Respiratory muscle pharmacotherapy, Chapter in: Problems in Respiratory Care; the respiratory muscles. MJ Tobin, editor. J.B. Lippincott: Philadelphia,. 1990; 3(3).
Tobin, MJ, Yang, KL, Mador MJ. Variability of breathing pattern. Chapter in: Sleep and Health Risks. Editors: Peter, JH, Podszus, T., von Wiechert, P. Springer-Verlag-Berlin. 1990.
Professional Memberships:
Member, College of Physicians and Surgeons of Ontario
Member/American Thoracic Society
Fellow - American College of Chest Physicians
Service Activities:
Manuscript reviewer/Am. J. of Respir. & Critical Care Med.; Reviewer
Manuscript reviewer/Chest; Reviewer
Manuscript reviewer/European Journal of Applied Physiology; Reviewer