M. Jeffery Mador MD

M. Jeffery Mador

M. Jeffery Mador
MD

Associate Professor of Medicine

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Pulmonary & Critical Care Medicine; Sleep Medicine

Contact Information
Veterans Hospital
3495 Bailey Avenue
Buffalo, New York 14215
Phone: (716) 862-8629
mador@buffalo.edu
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Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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Overview Research Publications Activities Latest News

Professional Summary:

My patient care responsibilities are centered at the Veterans Administration Western New York Healthcare System (VA) where I care for hospitalized patients with pulmonary problems as well as maintain two active outpatient clinics in the VA system: the pulmonary clinic and the sleep medicine clinic. I also supervise the continuity clinics at the VA. I also have a sleep clinic at UBMD sleep.

My research interests dovetail with my clinical work. I conduct research on skeletal muscle function in patients with chronic obstructive pulmonary disease (COPD) and those patients in pulmonary rehabilitation. I investigate predictors of the response to pulmonary rehabilitation, and I am also interested in sleep apnea research, comparing the occurrence of complications (postoperative and others) between patients with sleep apnea and those without. I examine sleep apnea treatment options and their success rate in special patient populations, such as patients with psychiatric disease or those on chronic opioid therapy.

I run multicenter trials in patients with COPD, and I am presently involved in one NIH-sponsored studies: examining the effects of weight loss and exercise on outcomes in patients with COPD and several pharmaceutical trials of agents to reduce exacerbations. I am involved in one NIH study examining the effects of preoperative respiratory muscle training on outcomes after surgical resection for patients with lung cancer. I am also involved in a VA sponsored trial of a specific supplement regimen and/or exercise on outcomes and skeletal muscle function in the healthy elderly.

I teach medical students primarily in the respiratory physiology course. I enjoy working with students throughout the full spectrum of medical education from first-year medical students to senior fellows in pulmonary critical care or sleep medicine. As the fellowship director for pulmonary critical care medicine, I am responsible for the educational curricula for the fellowship.

Education and Training:
  • Residency, University of Toronto (1984)
  • MD, Medicine, University of Toronto (1981)

Employment:
  • Chief, Section of Sleep, University at Buffalo (2015-present)
  • Director - Pulmonary- Critical Care fellowship program, Univ at Buffalo, Jacobs School of Medicine (2003-present)
  • Staff Physician, Pulmonary Critical Care and Sleep Section, Buffalo VA Medical Center (1987-present)
  • Director, Sleep Lab Sleep and Wellness WNY, University at Buffalo (2015-present)
  • Director, Pulmonary Critical Care Fellowship, Pulmonary & Critical Care, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2004-present)
  • Associate Professor, Medicine, University at Buffalo (1994-present)
  • Staff Physician, VAMC (1987-present)
  • Director, Medical Intensive Care Unit, VAMC
  • Director, Sleep Laboratory, VAMC (1997–2011)
  • Associate Director, Pulmonary Critical Care Fellowship, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001–2004)
  • Attending Physician, Sister's of Charity Hospital (1996–2001)
  • Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1987–1994)
  • Fellow, Pulmonary Critical Care, University of Texas at Houston Jacobs School of Medicine & Biomedical Sciences (1984–1987)
See all (3 more)

Awards and Honors:
  • Research Award (1986)
  • Research Award (1984)
  • Alpha Omega Alpha Honor Medical Society (1980)
  • CD Wainwright Scholarship (1978)
  • Ann Shepard Memorial Scholarship (1976)
  • Academic Proficiency (1975)

Research Expertise:
  • Assessment of respiratory muscle function
  • Clinical implications of sleep apnea
  • New therapeutics in COPD
  • Outcomes of pulmonary rehabilitation

Grants and Sponsored Research:
  • March 2023–March 2027
    The benefits of nicotinamide riboside upon cognition and sleep in older adults
    NIH
    Role: Co-Investigator
  • October 2018–September 2020
    Enhancing Functional Capacity in Older Adults with Short Session High Intensity Interval Training
    VA Rehabilitation Research & Development Service
    Role: Co-Investigator
    $200,000
  • November 2014–July 2018
    A Randomised, Double-blind, Chronic Dosing (56 week) Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of 2 Doses of Benralizumab (MEDI-563) in Patients with Moderate to Very Severe Chronic Obstructive P
    Role: Co-Investigator
  • February 2014–February 2017
    A Clinical Outcomes Study to Compare the Effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25MCG with Placebo on Survival in Subjects with Moderate Chronic Obstructive Pulmonary Disease (COPD) and a History of or at Increased Risk for Cardio
    BIMR
    Role: Principal Investigator
    $48,000
  • November 2013–December 2016
    Double-blind, Randomized, Placebo-Controlled, Parallel-Group, Phase IV Study to Evaluate the Effect of Acidinium Bromide on Long-Tern Cardiovascular Safety and COPD Exacerbations in Patients with Moderate to Very Severe COPD (Ascent)
    BIMR
    Role: Principal Investigator
    $52,000
  • August 2013–December 2016
    Long term oxygen treatment trial.
    NIH
    Role: Principal Investigator
  • February 2011–September 2015
    LOTT study
    NIH
    Role: Co-Investigator
    $128,800
  • February 2011–March 2014
    Statcope
    NIH
    Role: Co-Investigator
    $78,616
  • April 2011–March 2012
    A prospective observational study to evaluate biomarkers in acute exacerbations in chronic obstructive pulmonary disease
    Medimmune
    Role: Co-Investigator
    $9,375
  • December 2006–December 2010
    Bronchitis and emphysema advice and training to reduce hospitalization (BREATH): A randomized controlled trial of disease management to prevent COPD hospitalizations. VA cooperative study site investigator.
    Role: Principal Investigator
    $2,428,742
  • January 2003–December 2004
    The effect of emphysema and exercise training on limb muscle function in the hamster.
    VA Research
    Role: Co-Investigator
    $30,000
  • January 2001–June 2003
    Randomized clinical study to mesaure relative responsiveness and validity of various health related quality of life indices in patients with chronic respiratory diseases
    McMaster University
    Role: Co-Investigator
    $25,000
  • October 1993–September 1996
    Peripheral and central components of diaphragmatic fatique
    VA Merit Review
    Role: Co-Investigator
    $175,600
  • October 1988–September 1990
    Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in congestive heart failure
    American Heart Association of New York
    Role: Co-Investigator
    $48,992
  • July 1988–June 1990
    Effect of pulmonary neuroreceptor blockage on ventilatory control and dyspnea in interstitial lung disease
    American Lung Association of New York
    Role: Co-Investigator
    $34,950
  • April 1988–March 1990
    Vagal Influences on ventilatory control in interstitial lung disease
    VAMC Research Advisory Group
    Role: Co-Investigator
    $20,000
  • February 1988–January 1990
    Effect of pulmonary neuroreceptor blockade on ventilatory control and dyspnea in interstitial lung disease
    Resarch & Development/BRSG Award
    Role: Co-Investigator
    $5,325
  • July 2021
    Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans
    RR&D
    Role: Co-Principal Investigator
    $1,199,995
  • September 2018
    Preoperative respiratory muscle training to prevent postoperative pulmonary complications in patients undergoing resection for lung cancer
    National Cancer Institute
    Role: Co-Investigator
    $2,315,330
  • May 2017
    Intervention Study in Overweight Patients with COPD (Insight COPD)
    NIH
    Role: Co-Investigator
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Journal Articles:

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Books and Book Chapters:

  • Mogri M., Mador MJ. (2013) Critical Care Management. In: Mechanical Ventilation of the Obese Patient. Wiley Blackwell, 67-73.
  • Mador MJ, Gibbons WJ. (2003) In: Invasive ventilation and the intensive care unit. Chapter in: Cronic Obstructive Pulmonary Disease, 2nd ed. Editors: P Calcerley & N Pride. Arnold Publishers, London, UK. , 415-438.
  • Magalang UJ, Mador MJ. (2002) In: Behavioral and pharmacologic therapy of obstructive sleep apnea. Chapter in: Sleep Medicine. Editors: Lee-Choing, TL, Carskadon, MA, Sateia, MJ. Hanley & Belfus, Inc. Philadelphia, PA. , 389-396.
  • Mador MJ, Tobin, MJ. (1995) Acute respiratory failure. Chapter in:Chronic obstructive pulmonary diseases. Editors: Calverley, PMA, Pride, NB. Chapman & Hall: London.
  • Mador M. (1994) In: Assist-control ventilation. Chapter in: Principles and practice of mechanical ventilation. Editor: MJ Tobin. McGraw-Hill, NY. , 207-219.
  • Mador MJ, Walsh, JM, Tobin, MJ. (1993) In: Work of breathing and respiratory muscle function. Chapter in: Monitoring in Respiratory Care. Editors: Kacmarek, RM, Hess, D, Stoller, JK. Mosby-Year Book, Inc. , 267-308.
  • Tobin, MJ, Yang, KL, Mador MJ. (1990) Variability of breathing pattern. Chapter in: Sleep and Health Risks. Editors: Peter, JH, Podszus, T., von Wiechert, P. Springer-Verlag-Berlin.
  • Mador M. (1990) In: Respiratory muscle pharmacotherapy, Chapter in: Problems in Respiratory Care; the respiratory muscles. MJ Tobin, editor. J.B. Lippincott: Philadelphia,. , 493-506.
  • Mador MJ, Shetty M. (1900) Positional sleep apnea. In: Prevalence of positional obstructive sleep apnea in patients undergoing polysomnography and the effect of sleep stage. (in press). Springer Science

Abstracts:

  • Dy R., Mador MJ. (2016) Dynamic arterial waveform changes as predictors of fluid responsiveness in intensive care unit patients: A systematic review and meta-analysis. American Thoracic Society, (Jan)
  • Mador M. (2016) A PET artifact masquerading as a PET positive lung mass. American Thoracic Society, (Jan)
  • Mador M. (2015) Efficacy of Bronchoscopic Lung Volume Reduction: Meta Analysis. American Thoracic Society, (Jan)
  • Kumar A., Mador MJ. (2015) Nodular cystic pulmonary disease in a non smoker. American Thoracic Society, (Jan)
  • Metta VVSR., Zaka A., Lee V., Mador MJ. (2015) Positive airway pressure adherence in patients with obstructive sleep apnea and symptomatic BPH. Sleep, (Jan)
  • Metta VVSR., Patel S.M., Singh S., Mador MJ. (2015) Positive Airway Pressure Adherence in Patients with Obstructive Sleep Apnea with Depression or Anxiety. Sleep, (Jan)
  • Gassam S., Gunukula S.K., Mador MJ. (2013) Post-operative outcomes in adult obstructive sleep apnea patients undergoing non-upper airway surgery: A systematic review and meta-analysis. Am J Respir Crit Care Med, (Jan)
  • Mogri M., Patel A., Mador MJ. (2012) Contractile fatigue of the quadriceps muscle predicts improvement in exercise performance after pulmonary rehabilitation. Am J Respir Crit Care Med, (Jan)
  • Mador MJ, Nadler JN, Khadka G., Gottumukkala V.A., Abo-Khamis M., Mehboob S. (2010) Do patients at risk of obstructive sleep apnea have an increased risk of cardiorespiratory complications during endoscopy procedures?. Am J Respir Crit Care Med, (Jan)
  • El Solh AA, Mador MJ, Ten Brock E, Shucard D, Grant BJ. (1998) Validity of an artificial neural network in predicting sleep apnea. (abstract). Am J Respir Crit Care Med, (Jan)

Professional Memberships:
  • Certification - ABIM - Sleep (2011–present)
  • Member - Association of Pulmonary Critical Care Program Directors (2005–present)
  • Association of Pulmonary Critical Care Program Directors (2004–present)
  • Member - American Thoracic Society (1987–present)
  • Certification - ABIM - Pulmonary (1986–present)
  • Member- American Thoracic Society (1985–present)
  • Certification - ABIM - Internal Medicine; Internal Medicine (1984–present)
  • Member, College of Physicians and Surgeons of Ontario (1981–2000)
  • Member - American Academy of Slee Medicine

Presentations:
  • "Postoperative and endoscopy complications and sleep apnea" American Thoracic Society 2015 (2015)

Service Activities:
  • Faculty Council Steering Committee; Member (2018–present)
  • Research and Development Committee, BVAMC, 198-1990; 1994-1997; 2000-2001; 2015 - (2015–present)
  • Research and Development Committee, Buffalo VA Medical Center; Member (2015–present)
  • IRB Member (2009–present)
  • IRB, Buffalo VA Medical Center; Member (2009–present)
  • IRB, Buffalo VA Medical Center; Chair (2006–2008)
  • IUCUC; Member (2005–2006)
  • Faculty Evaluation; Member (2000–2001)
  • fellowship director; fellowship director pulmonary critical care (2000–present)
  • Research and Development Committee, Buffalo VA Medical Center; Member (2000–2001)
  • Biomedical Research; Member (1999–2002)
  • Appointment & Promotions to Clinical Ranks; Member (1997–2000)
  • Research and Development Committee, Buffalo VA Medical Center; Member (1994–1997)
  • Student Internal Medicine Curriculum Committee; Member (1993–present)
  • Internal Medicine Curriculum Development Committee; Member (1992–1993)
  • Respiratory CQI; Member (1992–1995)
  • Respiratory CQI Committee, Buffalo VA Medical Center; Member (1992–1995)
  • Intensive Care Unit; Member (1991–1999)
  • Intensive Care Unit Committee, Buffalo VA Medical Center; Member (1991–1999)
  • Advisory committee-Critical Care Clinical Specialist Graduate Program; Advisor (1990–present)
  • Respiratory Therapy Board - Buffalo VA Medical Center; Member (1989–2010)
  • Respiratory Therapy Board; Member (1989–1995)
  • Research and Development Committee, Buffalo VA Medical Center; Member (1988–1990)
  • Manuscript reviewer/J. of Applied Physiology; Panel Member
  • Manuscript reviewer/Medicine in Sports and Exercise Science; Reviewer
  • Manuscript reviewer/Respiration Physiology; Reviewer
  • Manuscript reviewer/Thorax; Reviewer
  • Manuscript reviewer/Am. J. of Respir. & Critical Care Med.; Reviewer
  • Manuscript reviewer/Chest; Reviewer
  • Manuscript reviewer/European Journal of Applied Physiology; Reviewer
  • Manuscript reviewer/European Respiratory Journal; Reviewer

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Contact Information

Veterans Hospital
3495 Bailey Avenue
Buffalo, New York 14215
Phone: (716) 862-8629
mador@buffalo.edu
View map
View faculty website

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD
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