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Richard                        Quigg Jr.

Richard J. Quigg Jr. MD

Department of Medicine

Arthur M. Morris Professor and Chief, Division of Nephrology

Specialty/Research Focus

Nephrology

 
Professional Summary:

Over the past 30 years, my outpatient focus has been the care and management of patients with complex glomerular and autoimmune diseases. I serve as attending physician on the renal consult services for UBMD Nephrology at Buffalo General Medical Center, Roswell Park Cancer Institute and Erie County Medical Center (ECMC). I am also an attending physician on the inpatient Medicine A (General Medicine) and D (Renal Medicine) services at ECMC.

My research concentrates on understanding mechanisms that underlie kidney disease, including the role of the complement system, a major factor in the body's immune response. My lab has developed and studied animal models of systemic lupus erythematosus, diabetic nephropathy, glomerulonephritis, obstructive nephropathy and acute renal failure. In addition to modeling disease in animals, we also have performed clinical studies both for promising new therapies and for those that focus on examining gene profiles from diseased renal tissue. To answer questions that arise in the course of our research, our work spans a number of disciplines and utilizes state-of-the-art approaches such as mouse kidney transplantation, 15-color flow cytometry and magnetic resonance imaging.

My original degree is in mathematics, which remains a passion of mine. I also am interested in computational biology and founded the Computation Biology Core Facility at the University of Chicago. The core strength and emphasis of UB in the area of clinical informatics was a key factor in my decision to accept a position here so that I can continue to contribute to projects related to this field. In collaboration with leadership from other disciplines at UB, I helped establish one of the first clinical informatics fellowship programs in the United States. As a result, we accepted in 2014 the first joint nephrology/clinical informatics trainee in the country.

As an educator, I am committed to the career development of the students, trainees and faculty working with me in my lab, in clinical research areas, in clinical informatics and in the clinical arena. Over the course of my career, I have mentored many outstanding students, fellows and faculty. Under my leadership and guidance, a number have received nationally competitive awards, and many have gone on to become academic leaders--including one who became a medical school dean. I serve on the Kidney, Urologic and Hematologic Diseases Subcommittee of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which critically evaluates training in nephrology. Through this commitment, I help ensure continued quality improvement in nephrology training, both nationally and at UB.

Education and Training:
  • Fellowship, Nephrology, Boston University Medical Center (1988)
  • Residency, Internal Medicine, University Hospital, SUNY-Stony Brook (1984)
  • MD, Internal Medicine, Boston University School of Medicine (1981)
  • BA, Medical Sciences, Mathematics Minor, Boston University, Summa cum laude (1981)
Employment:
  • Professor of Medicine, University at Buffalo (2013-present)
  • Professor of Medicine, Emeritus, University of Chicago, The University of Chicago (2013-present)
  • Adjunct Professor of Oncology, Roswell Park Cancer Institute (2013-present)
  • Chief, Division of Nephrology, University at Buffalo (2013-present)
  • Professor of Biomedical Informatics, University at Buffalo (2013-present)
  • Professor of Medicine, University of Chicago (2001–2013)
  • Director, University of Chicago Functional Genomics Facility (2000–2010)
  • Chief, Section of Nephrology, University of Chicago (1999–2009)
  • Associate Professor of Medicine, University of Chicago (1994–2001)
  • Assistant Professor Medicine, Medical College of Virginia (1988–1994)
  • Research Instructor in Medicine, Boston University School of Medicine (1987–1988)
See All (11 Total) >
Awards and Honors:
  • Fellow, American College of Physicians (2014)
  • Teacher of the Year, University of Chicago, Nephrology Section (2011)
  • Member, American Society for Clinical Investigation (2003)
  • Granted tenure (1999)
  • Falk Award of Excellence, Arthritis Foundation, Greater Chicago (1997)
  • XVth International Complement Workshop Travel Award, Kyoto, Japan (1993)
  • American Society of Nephrology Travel Award (1993)
  • XIVth International Complement Workshop Travel Award (1991)
  • First Independent Research Support Transition Award, NIH (1989)
  • American Society of Nephrology Travel Award (1987)
  • Individual National Research Service Award, NIH (1986)
  • Summa cum laude (1981)

Research Expertise:
  • Clinical informatics
  • Experimental models of renal disease
  • Pathobiology of the complement system
Research Centers:
  • Clinical and Translational Research Center (CTRC)
Grants and Sponsored Research:
  • January 2008–January 2013
    Nephrology Research Training
    National Institutes of Health
    Role: Principal Investigator
  • January 2010–January 2012
    Endothelial and Renal Tubular FcRn Returns Albumin to the Circulation Preventing its Degradation and Albuminuria
    American Heart Association Grant-in-Aid
    Role: Principal Investigator
  • January 2007–January 2012
    Role of the Complement System in Renal Disease
    National Institutes of Health
    Role: Principal Investigator
  • January 2010–January 2011
    Therapeutic Complement Manipulation in a Novel Murine Lupus Nephritis Model
    Lupus Foundation of America
    Role: Principal Investigator
  • January 2005–January 2010
    Pathogenic Role of the Complement System in Murine Lupus
    National Institutes of Health
    Role: Principal Investigator
  • January 2006–January 2008
    Targeting Complement Inhibitors to the Proximal Tubule
    National Institutes of Health
    Role: Principal Investigator
  • January 2006–January 2007
    Role of Epigenetic Alterations in Diabetic Nephropathy
    Juvenile Diabetes Research Foundation, Innovation Grant
    Role: Principal Investigator
  • January 2002–January 2006
    Role of the Complement System in Glomerulonephritis
    National Institutes of Health
    Role: Principal Investigator
  • January 2004–January 2005
    Evaluation of Antisense Therapies in MRL/Ipr Mice, A Spontaneous Model of Lupus
    Antisense Therapeutics
    Role: Principal Investigator
  • January 2002–January 2005
    Gene Changes in the Kidneys and Blood Cells of Patients with Active Lupus Nephritis and the Response of These to Successful Treatment
    GenLogic
    Role: Principal Investigator
  • January 2001–January 2004
    Massively Parallel DNA Analysis
    National Institutes of Health, NIDDK Biotechnology Centers
    Role: Principal Investigator
  • January 2001–January 2004
    Anti-C5 Therapy of Lupus Nephritis
    National Institutes of Health, Autoimmunity Center of Excellence
    Role: Principal Investigator
  • January 1999–January 2003
    Pathogenic Role of the Complement System in Murine Lupus
    National Institutes of Health
    Role: Principal Investigator
  • January 2001–January 2002
    Adminstrative Supplement for the Study of Type 1 Diabetes Gene Targets
    National Institutes of Health
    Role: Principal Investigator
  • January 2000–January 2002
    Genetic and Pathologic Alterations in Murine Diabetes
    National Institutes of Health
    Role: Principal Investigator
  • January 1998–January 2002
    Role of the Complement System in Glomerulonephritis
    National Institutes of Health
    Role: Principal Investigator
  • January 2000–January 2001
    Administrative Supplement for Gene Profiling Resources
    National Institutes of Health
    Role: Principal Investigator
  • January 1998–January 2000
    Effects of Complement Inhibition in Experimental Rheumatoid Arthritis
    Arthritis Foundation, Greater Chicago Chapter, Biomedical Sciences Grant
    Role: Principal Investigator
  • January 1997–January 1998
    Effects of Complement Inhibition in Glomerulonephritis
    National Kidney Foundation, Grant in Aid
    Role: Principal Investigator
  • January 1996–January 1997
    Isolation and Characterization of Rodent Immune Adherence Receptors
    Arthritis Foundation, Greater Chicago Chapter, Biomedical Sciences Grant
    Role: Principal Investigator
  • January 1993–January 1996
    Abnormal Complement Regulations in Glomerulonephritis
    American Heart Association, National Center, Grant in Aid
    Role: Principal Investigator
  • January 1994–January 1995
    Abnormal Complement Regulation in Glomerulonephritis
    National Institutes of Health
    Role: Principal Investigator
  • January 1989–January 1994
    Complement Activation on the Glomerular Epithelial Cell
    National Institutes of Health
    Role: Principal Investigator
  • January 1992–January 1993
    Complement Activation on the Glomerular Epithelial Cell
    National Kidney Foundation of Virginia, Research Grant
    Role: Principal Investigator
See All (24 Total) >
Patents:
  • Tissue targeted complement modulators Systemic suppression of the complement system has been shown to be effective to treat inflammatory disease, yet at the potential cost of compromising host defense and immune homeostasis. Herein disclosed are methods for antigen-specific targeting of complement inhibitors that show that complement inhibitors targeted to the proximal tubular epithelium protect against tubulointerstitial injury and renal dysfunction in a rat model of nephrosis. It is shown that appropriate targeting of a systemically administered complement inhibitor to a site of disease markedy enhances efficacy and obviates the need to systemically inhibit complement. Additionally, it is shown by specifically inhibiting the terminal pathway of complement, that the membrane attack complex (MAC) plays a key role in proteinuria-induced tubulointerstitial injury, thus establishing the MAC as a valid target for pharmacological intervention in proteinuric disorders. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system. (2013)
  • Method for determining biological expression levels by linear programming (2006)

Evaluative Studies and Case Reports:
Journal Articles:
See All (103 Total) >

Professional Memberships:
  • American Medical Informatics Association (2012)
  • American Society for Clinical Investigation (2003)
  • American Society for Biochemistry and Molecular Biology (2002)
  • University of Chicago Cancer Research Center (2000)
  • American Heart Association, Council on the Kidney in Cardiovascular Disease (1993)
  • American Association of Immunologists (1992)
  • National Kidney Foundation (1990)
  • American Association for the Advancement of Science (1988)
  • American Society of Nephrology (1986)
  • International Society of Nephrology (1986)
  • International Society of Nephrology (1986)
Presentations:
  • "Keynote Address: Bench to Bedside....and Back Again. The Unique Walk of a Physician Scientist" New York MD/ PhD Research Day (2013)
  • "Role of Complement in Autoimmune Renal Disease" American Society of Nephrology Annual Meeting:Advances in Research Conference, Autoimmunity and Allimmunity (2012)
  • " Membranous Nephropathy: Complement and Complement Receptors" 2nd International Conference on Membranous Nephropathy (2012)
  • "SLE and Complement" Immunology Education Day: Bridging the Gap for Bench to Bedside (2011)
  • "Renal Disorders Caused by Neoplasm and Anti-neoplastic Agents" Oncology Grand Rounds, The University of Chicago (2010)
  • " Complement Components in Membranous Nephropathy" International Society of Nephrology Meeting (2009)
  • "Inhibiting Complement Activation: Therapeutic Potential and Pitfalls?" American Society of Nephrology Annual Meeting (2008)
  • "Complement Activation in Membranous Nephrolpathy: Can We Intervene Therapeutically?" American Society of Nephrology Annual Meeting (2007)
  • "The End-Stage Renal Disease That Went Away-Case Reports of Wegener's Granulomatosis and 1 degree Anti-Phospholipid Syndrome" Medical Grand Rounds, The University of Chicago (2007)
  • "Why the Interaction of Factor H with the Glomerular Endothelium is So Important" World Congress of Nephrology, Vascular Biology Symposium (2007)
  • "Regulation of Experimental Autoimmune Nephritis by C3a and C5a" American Society fo Nephrology Annual Meeting (2006)
  • "Complement Activation and Tubulointerstitial Nephritis" American Society of Nephrology Annual Meeting (2005)
  • "Is the Movie GATACA Science Fiction?" Medical Grand Rounds, University of Chicago (2005)
  • "Role of Complement in Experimental Systemic Lupus Erythematosus" UT Southwestern Medical Center at Dallas Excellence in Immunology Lecture Series" (2004)
  • "Career Choices in Nephrology" National Kidney Foundation Meetings (2004)
  • "Lupus Nephritis-Observations from the Experimental Animal and Potentios Treatment Options in Clinical Disease" Peruvian Society of Nephrology (2004)
  • "The Role of the Complement System in Renal Disease" World Congress of Nephrology Satellite Symposium (2003)
  • "Use of Contemporary Molecular Biological Tools to Sissect the Pathogenesis of Experimental Renal Diseases" The 7th Research Forum on Progressive Renal Diseases (2003)
See All (18 Total) >
Service Activities:
  • American Society of Nephrology Basic Science Committee; Committee Member (2004–2010)
  • NIDDK Glomerular Disease Workshop Planning Committee; Committee Member (2004–2005)
  • American Society of Nephrology 2004 Annual Meeting Program Committee; Committee Member (2003–2004)
  • Councilor, Central Society for Clinical Research; Councilor (1999)
  • National Animal Care and Use Committee, The University of Chicago; Committee Member (1998–2000)
  • Department of Medicine Search Committee, Chairman of Medicine, The University of Chicago; Committee Member (1998)
  • Clinical Affairs Committee, Section of Nephrology, The University of Chicago; Committee Member (1996–1999)
  • Program Committee, American Heart Association, Council on the Kidney in Cardiovascular Disease; Committee Member (1996–1999)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

Clinical Translational Research Center
875 Ellicott Street, Suite 8030
Buffalo, NY 14203
Phone: 716-888-4826
Email: rquigg@buffalo.edu

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