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Richard                        Quigg Jr.

Richard J. Quigg Jr. MD

Department of Medicine

Arthur M. Morris Professor and Chief, Division of Nephrology

Specialty/Research Focus

Nephrology

 
Professional Summary:

Over the past 30 years, my outpatient focus has been the care and management of patients with complex glomerular and autoimmune diseases. I serve as attending physician on the renal consult services for UBMD Nephrology at Buffalo General Medical Center, Roswell Park Cancer Institute and Erie County Medical Center (ECMC). I am also an attending physician on the inpatient Medicine A (General Medicine) and D (Renal Medicine) services at ECMC.

My research concentrates on understanding mechanisms that underlie kidney disease, including the role of the complement system, a major factor in the body's immune response. My lab has developed and studied animal models of systemic lupus erythematosus, diabetic nephropathy, glomerulonephritis, obstructive nephropathy and acute renal failure. In addition to modeling disease in animals, we also have performed clinical studies both for promising new therapies and for those that focus on examining gene profiles from diseased renal tissue. To answer questions that arise in the course of our research, our work spans a number of disciplines and utilizes state-of-the-art approaches such as mouse kidney transplantation, 15-color flow cytometry and magnetic resonance imaging.

My original degree is in mathematics, which remains a passion of mine. I also am interested in computational biology and founded the Computation Biology Core Facility at the University of Chicago. The core strength and emphasis of UB in the area of clinical informatics was a key factor in my decision to accept a position here so that I can continue to contribute to projects related to this field. In collaboration with leadership from other disciplines at UB, I helped establish one of the first clinical informatics fellowship programs in the United States. As a result, we accepted in 2014 the first joint nephrology/clinical informatics trainee in the country.

As an educator, I am committed to the career development of the students, trainees and faculty working with me in my lab, in clinical research areas, in clinical informatics and in the clinical arena. Over the course of my career, I have mentored many outstanding students, fellows and faculty. Under my leadership and guidance, a number have received nationally competitive awards, and many have gone on to become academic leaders--including one who became a medical school dean. I serve on the Kidney, Urologic and Hematologic Diseases Subcommittee of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which critically evaluates training in nephrology. Through this commitment, I help ensure continued quality improvement in nephrology training, both nationally and at UB.

Education and Training:
  • Fellowship, Nephrology, Boston University Medical Center (1988)
  • Residency, Internal Medicine, University Hospital, SUNY-Stony Brook (1984)
  • MD, Internal Medicine, Boston University School of Medicine (1981)
  • BA, Medical Sciences, Mathematics Minor, Boston University, Summa cum laude (1981)
Employment:
  • Professor of Medicine, University at Buffalo (2013-present)
  • Professor of Medicine, Emeritus, University of Chicago, The University of Chicago (2013-present)
  • Adjunct Professor of Oncology, Roswell Park Cancer Institute (2013-present)
  • Chief, Division of Nephrology, University at Buffalo (2013-present)
  • Professor of Biomedical Informatics, University at Buffalo (2013-present)
  • Professor of Medicine, University of Chicago (2001–2013)
  • Director, University of Chicago Functional Genomics Facility (2000–2010)
  • Chief, Section of Nephrology, University of Chicago (1999–2009)
  • Associate Professor of Medicine, University of Chicago (1994–2001)
  • Assistant Professor Medicine, Medical College of Virginia (1988–1994)
  • Research Instructor in Medicine, Boston University School of Medicine (1987–1988)
See All (11 Total) >
Awards and Honors:
  • Fellow, American College of Physicians (2014)
  • Teacher of the Year, University of Chicago, Nephrology Section (2011)
  • Member, American Society for Clinical Investigation (2003)
  • Granted tenure (1999)
  • Falk Award of Excellence, Arthritis Foundation, Greater Chicago (1997)
  • XVth International Complement Workshop Travel Award, Kyoto, Japan (1993)
  • American Society of Nephrology Travel Award (1993)
  • XIVth International Complement Workshop Travel Award (1991)
  • First Independent Research Support Transition Award, NIH (1989)
  • American Society of Nephrology Travel Award (1987)
  • Individual National Research Service Award, NIH (1986)
  • Summa cum laude (1981)

Research Expertise:
  • Clinical informatics
  • Experimental models of renal disease
  • Pathobiology of the complement system
Research Centers:
  • Clinical and Translational Research Center (CTRC)
Patents:
  • Tissue targeted complement modulators Systemic suppression of the complement system has been shown to be effective to treat inflammatory disease, yet at the potential cost of compromising host defense and immune homeostasis. Herein disclosed are methods for antigen-specific targeting of complement inhibitors that show that complement inhibitors targeted to the proximal tubular epithelium protect against tubulointerstitial injury and renal dysfunction in a rat model of nephrosis. It is shown that appropriate targeting of a systemically administered complement inhibitor to a site of disease markedy enhances efficacy and obviates the need to systemically inhibit complement. Additionally, it is shown by specifically inhibiting the terminal pathway of complement, that the membrane attack complex (MAC) plays a key role in proteinuria-induced tubulointerstitial injury, thus establishing the MAC as a valid target for pharmacological intervention in proteinuric disorders. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system. (2013)
  • Method for determining biological expression levels by linear programming (2006)

Evaluative Studies and Case Reports:
Journal Articles:
See All (103 Total) >

Professional Memberships:
  • American Medical Informatics Association (2012)
  • American Society for Clinical Investigation (2003)
  • American Society for Biochemistry and Molecular Biology (2002)
  • University of Chicago Cancer Research Center (2000)
  • American Heart Association, Council on the Kidney in Cardiovascular Disease (1993)
  • American Association of Immunologists (1992)
  • National Kidney Foundation (1990)
  • American Association for the Advancement of Science (1988)
  • American Society of Nephrology (1986)
  • International Society of Nephrology (1986)
  • International Society of Nephrology (1986)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

Clinical Translational Research Center
875 Ellicott Street, Suite 8030
Buffalo, NY 14203
Phone: 716-888-4826
Email: rquigg@buffalo.edu

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