This facility maintains a toxicology laboratory, an analytical laboratory and a biodegradation laboratory, offering a wide variety of analytical research services.

We are available to consult with investigators in writing the analytical section of outgoing grants and preparing quotes for specific work on a funded project.

This multiuser facility houses instrumentation for conducting cellular, biochemical and molecular studies. We have the protocols for preclinical drug testing in support of New Drug Applications, where our primary focus has been on radiodiagnostic drugs, particularly brain imaging agents.

We maintain a wide variety of resources for investigators including:

• a Krumdieck precision-cut tissue slicer, custom designed incubators, a Wallac Tri/Lux Microbeta Scintillation Chemiluminescence Counter, microplate readers, densitometers and much more equipment
  
• in vitro models useful for comparative studies
• primary tissue explant models
• cell culture using various cell lines
• an array of biochemical and molecular techniques
• Single Stranded Conformation Polymorphism (SSCP) and Restriction Fragment Length Polymorphism (RFLP) analysis for studies in toxicogenomics

This laboratory concentrates on sample analysis, data analysis and the development of new analytical techniques. We also participate in nationwide proficiency programs for PCBs, pesticides and mercury.

We can perform numerous analytical techniques including HPLC with diode array and GC-MS. We also can adapt our techniques to individuals' needs.

We have developed our own techniques to evaluate antimicrobial activity on a wide range of materials using a variety of test microbes, and we can test the effects of the agent on the function of the treated material.

We conduct both laboratory and field studies. We're able to study the mechanisms of degradation of polyolefins, halogenated organics and PAHs. An OWS in-lab composting facility is capable of running 32 reactors simultaneously, with synchronous sampling of volatile organics and on-line GC measurement.

212 Farber Hall