We conduct ongoing research in the areas of pulmonary biology,
including study of the pulmonary vasculature, cell and molecular
biologic studies of acute and chronic lung injury of the newborn,
pulmonary hypertension, oxidant lung injury, inflammation and
The main focus of research in our division is neonatal transition
at birth, disorders of neonatal transition and neonatal
resuscitation. Faculty members in our division have received
funding from NIH, American Academy of Pediatrics and Industry.
Faculty and fellows regularly present at Pediatric Academic Society
Clinical research areas of interest include the role of breast
milk in preventing nosocomial infection, varying oxygen
concentrations levels for premature infant resuscitation, post-PPHN
systemic hypertension, the effect of dexamethasone on nitric oxide
pathway metabolites, osteopenia of prematurity, aspiration and
gram-negative pneumonia in the development of bronchopulmonary
dysplasia, booster surfactant during the development of
bronchopulmonary dysplasia and the use of HVAC ultraviolet
germicidal irradiation in decreasing nosocomial infection.
We are evaluating the pathophysiology of necrotizing enterocolitis
(NEC) and its relation to prematurity, enteral feeds, ischemia and
Since 2011, we have been a part of the NICHD neonatal research
network - a consortium of 18 universities and affiliated neonatal
intensive care units dedicated to conducting multicenter trials to
improve the outcome of critically ill newborn infants.
The 64-bed NICU at Women & Children’s Hospital of
Buffalo admits approximately 750 to 800 babies each year and
has an average daily census of 50 to 55 babies.
Approximately one-third of admissions are transported from an
outlying hospital by our Neonatal Transport Team. Our team consists
of neonatal nurse practitioners and specially trained neonatal
respiratory therapists, readily available to provide stabilization
and transport for any infant in our region.
Women & Children’s Hospital of Buffalo is the only
center in the region with pediatric surgery and pediatric surgical
subspecialists, a full complement of pediatric medical
subspecialists, and obstetricians with board certification in
maternal-fetal medicine (high-risk obstetrics). This regional
perinatal center (RPC) provides whole body hypothermia with
continuous EEG monitoring for newborn infants with hypoxic-ischemic
encephalopathy and Extracorporeal Membrane Oxygenation (ECMO) for
infants with hypoxic respiratory failure. The hospital’s NICU
admits approximately 150 infants each year who weigh less than
1,500 grams at birth. As the regional referral center, we provide
support to 18 other hospitals in our region, including our Level I
unit at Millard Fillmore Suburban Hospital.