Brian J. Page MD
Brian J. Page
MD
Associate Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cardiology; Cardiovascular Disease
Professional Summary:
As a general cardiologist, I care for patients with a spectrum of cardiovascular diseases, including acute and chronic manifestations of coronary artery disease, congestive heart failure, cardiomyopathies, valvular disorders, arrhythmias and aortic and pericardial diseases. I have expertise in the role of echocardiography and nuclear cardiac imaging for the evaluation of cardiac disorders, including transesophageal echocardiography (TEE), nuclear stress testing (myocardial perfusion imaging), viability imaging and multiple-gated acquisition scan (MUGA) studies for evaluation of cardiac function. I also perform stress testing, electrical cardioversions to manage arrhythmias and interpret electrocardiograms (EKGs). I care for inpatients in the critical care and cardiac monitoring units (telemetry) at the Buffalo General Medical Center (BGMC) and the Gates Vascular Institute (GVI), and I provide consultative services there as well. I continue to provide care for patients after they are discharged from the hospital, and I also provide outpatient consultations at the UBMD Internal Medicine office in Amherst. I care for patients with chronic cardiac conditions, evaluate patients with chest pain or shortness of breath and provide preventative cardiology services for patients with hypertension and hyperlipidemia. I am also part of a multidisciplinary team that cares for patients with sarcoidosis, an inflammatory condition that can affect the heart.
My research interests are focused on clinical cardiac imaging. They include using single photon emission computed tomography (SPECT) to evaluate patients with mildly elevated biomarkers of cardiac injury and elucidate mechanisms of transient ischemic dilation of the left ventricle in patients without significant coronary artery disease. I also help supervise positron emission tomography (PET) studies at the UB Clinical and Translational Research Center (CTRC) in patients with ischemic heart disease, to better identify patients at risk of sudden cardiac death from ventricular arrhythmias.
As program director for the fellowship in cardiovascular disease, I organize the fellowship didactic curriculum and case discussions. I mentor the fellows and coordinate their training to help them achieve their specific career goals, including their preparation for subspeciality training in interventional cardiology, electrophysiology, heart failure or advanced cardiac imaging.
I also teach medical students and residents. I teach in the second-year medical student cardiovascular curriculum, and I coordinate and lead small-group case discussions for third- and fourth-year medical students. I also provide didactic teaching to residents.
Education and Training:
- Fellowship, Cardiovascular Disease, University at Buffalo (2009)
- Residency in Internal Medicine, University at Buffalo (2006)
- MD, Medicine, University at Buffalo, Cum Laude (2003)
- BA, Biochemistry, Canisius College, Summa Cum Laude (1999)
Employment:
- Associate Professor, University at Buffalo (2015-present)
- Program Director, Fellowship in Cardiovascular Medicine, University at Buffalo (2014-present)
- Research Assistant Professor, Medicine, University at Buffalo (2009–2015)
Awards and Honors:
- Gold Humanism Honor Society, Inductee (2017)
- White Coat Teaching Award (2013)
- ACP Annual Scientific Meeting Resident Research - 2nd Place (2013)
- F. Carter Pannill Jr., MD Award (2012)
- ACC Young Investigator Award Competition - 2nd Place (2010)
- 1st Place SUNY at Buffalo 9th Annual Resident Scholarly Exchange day (2006)
- Lawrence H. Golden, MD Intern Award (2004)
Research Expertise:
- Chronic adaptations to myocardial ischemia
Journal Articles:
- Mosleh W, Kattel S, Bhatt H, Al-Jebaje Z, Khan S, Shah T, Dahal S, Khalil C, Frodey K, Elibol J, Sonkawade SD, Ghanim H, Page B, Chaudhari MR, Sharma UC, Sharma U. Galectin-3 as a Risk Predictor of Mortality in Survivors of Out-of-Hospital Cardiac Arrest. Circ Arrhythm Electrophysiol. 2019; 12(10).
- Mosleh W, Chaudhari MR, Sonkawade S, Mahajan SD, Khalil C, Frodey K, Shah T, Dahal S, Karki R, Katkar R, Blankesteijn WM, Page BJ, Pokharel S, Kim M, Sharma UC. The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study. Biomark Insights. 2018; 13.
- Mosleh W, Sharma A, Sidhu MS, Page B, Sharma UC, Farkouh ME. The Role of SGLT-2 Inhibitors as Part of Optimal Medical Therapy in Improving Cardiovascular Outcomes in Patients with Diabetes and Coronary Artery Disease.. Cardiovasc Drugs Ther. 2017; 31(3).
- Douglas, PS, Page BJ. Outcomes of Anatomical Versus Functional Testing for Coronary Artery Disease. New England Journal of Medicine. 2015; 372.
- Page BJ, Banas MD, Suzuki G, Weil BR, Young RF, Fallavollita JA, Palka BA and Canty JM Jr. Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. J Am College Card. 2015; 65(7).
- Qu J, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM. Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models J Proteome Res. 2014; 13(5).
- Qu J, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM Jr. A reproducible ion current-based approach for 24-plex comparison of the tissue proteomes of hibernating vs normal myocardium in swine models. J Proteome Research. 2014; 13(5).
- Page BJ, RF Young, JA Fallavollita and Canty Jr JM. The physiological significance of a coronary stenosis differentially affects contractility and mitochondrial function in viable chronically dysfunctional myocardium.. Basic Res Cardiol. 2013; 108(4).
- Tu C, Li J, Young R, Page BJ, Engler F, Halfon MS, Canty JM, Qu J. Combinatorial peptide ligand library treatment followed by a dual-enzyme, dual-activation approach on a nanoflow liquid chromatography/orbitrap/electron transfer dissociation system for comprehensive analysis of swine plasma proteome Anal Chem. 2011; 83(12).
- Tu C, J Li, R Young, BJ page, F. Engler, MS Halfon, JM Canty Jr. and J Qu.. Combinatorial peptide ligand library treatment followed by a dual-enzyme, dual-activation approach on a nanoflow liquid chromatography/orbitrap/electron transfer dissocation system for comprehensive analysis of swine plasma proteome.. Anal. Chem.. 2011; 2(2).
- Page BJ, Kireyev D, Boden WE. The role of revascularization versus medical therapy in patients with type 2 diabetes mellitus and coronary artery disease Curr Diab Rep. 2010; 10(1).
- Hu Q, Suzuki G, Young RF, Page BJ, Fallavollita JA, Canty JM. Reductions in mitochondrial O(2) consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium Am J Physiol Heart Circ Physiol. 2009; 297(1).
- Kireyev D, Yun EC, Page BJ, Boden WE. Medical therapy in acute coronary syndromes: which medicines and at what doses? Curr Cardiol Rep. 2009; 11(4).
- Duan X, Young R, Straubinger RM, Page B, Cao J, Wang H, Yu H, Canty JM, Qu J. A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled with a long gradient nano-LC separation and Orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome J Proteome Res. 2009; 8(6).
- Page B, Young R, Iyer V, Suzuki G, Lis M, Korotchkina L, Patel MS, Blumenthal KM, Fallavollita JA, Canty JM Jr.. Persistent Regional Downregulation in Mitochondrial Enzymes and Upregulation of Stress Proteins in Swine with Chronic Hibernating Myocardium Circulation Research. 2008; 102.
Abstracts:
- Papadopoulos G, Vakkalanka S, Adib K, Sharma U,Page BJ. Clinical utility of coronary computed tomography angiography to evaluate patients with mildly elevated troponins without clinically manifest acute coronary syndrome. J Am College of Card. 2016; 67(13).
- Weil BR, Page BJ, Banas MD, Suzuki G and Canty, Jr., JM. Arteriolar remodeling limits maximal perfusion after percutaneous revascularization of a chronic stenosis in pigs with hibernating myocardium. FASEB J. 2012; 26.
- Banas MD, Page B, Young RF, Fallavollita JA and Canty Jr JM. Residual dysfunction after revascularization of hibernating myocardium is independent of fibrosis and secondary to myocyte loss and persistent regional reductions in mitochondrial oxidative enzymes. Circulation. 2006; 114.
Evaluative Studies and Case Reports:
- Ahmed, M, Yatsynovich, Y, Ramanan, T, Colern, G, Hansen, R, Cimato TR, Graham S, Page BJ, Iyer VS. Aortic Paravalvular Leak Repair. J Case Rep Images Med. 2017; 3.
- Younus U, Abbott B, Narasimha D, Page BJ. Coronary subclavian steal syndrome: An unusual cause of angina in a post-CABG patient. Case Reports in Cardiology. 2014; 2014.
- Kireyev D, Page B, Young HG. Septal infarction and complete heart block following percutaneous coronary intervention of the left anterior descending coronary artery J Invasive Cardiol. 2009; 21(3).
Professional Memberships:
- Fellow, American College of Cardiology (2015–present)
- American College of Cardiology (2009–2015)
- American Heart Association (2009–present)
Presentations:
- "A Multidisciplinary Checklist for Management of Acute Decompensated Heart Failure" American Heart Association's Quality of Care and Outcomes Research Annual Scientific Sessions 2016 (2016)
- "Single Center Retrospective Cohort Study of Impact of Contrast-enhanced Transthoracic Echocardiography on Evaluation of Left Ventricular Thrombus and Anticoagulation" American Society of Echocardiology Annual Scientific Sessions 2016 (2016)
- "Clinical Utility of Coronary Computed Tomography Angiography to Evaluate Patients with Mildly Elevated Troponins Without Clinically Manifest Acute Coronary Syndrome" American College of Cardiology Annual Scientific Session 2016 (2016)
- "Virtuous Intentions, Malign Consequences?" American College of Cardiology Annual Scientific Session 2015, ACC (2016)
- "Relevance of Diagnosing Patent Foramen Ovale (PFO) in the elderly with Ischemic Stroke" 12th Annual American Medical Association Research Symposium (2014)
- "Don't Steal My Beating Heart: Coronary Subclavian Steal Syndrome." University at Buffalo Department of Medicine Research Day, University at Buffalo (2014)
- "Anomalous Single Coronary Artery Stenosis Presenting as Non-ST Segment Myocardial Infarction: A Pictorial Case Report Presented in Coronary Angiogram Photographs." University at Buffalo Department of Medicine Research Day, University at Buffalo (2013)
- "Levels with Echocardiograhic Parameters of Diastolic Function in Patients with Heart Failure and Normal Left Ventricular Systolic Function" ACP Annual Scientific Meeting New York Chapter, Resident Research (2013)
- "Arteriolar Remodeling Limits Maximal Perfusion after Percutaneous Revascularization of Chronic Stenosis in Pigs with Hibernating Myocardium" FASEB, FASEB (2012)
- "Temporal Progression of Changes in Protein Expression and Mitochondrial Respiration in Viable Chronically Dysfunctional Myocardium" ACC 2010, American College Cardiology, Young Investigator Award Competition (2010)
- "Temporal Progression of Changes in Protein Expression and Mitochondrial Respiration in Viable Chronically Dysfunctional Myocardium" American College of Cardiology Scientific Sessions 2010 (2010)
- "Intracoronary Mesenchymal Stem Cells (MSCs) Improve Regional Function with a Differential Effect on Glycolytic and Mitochondrial Metabolic Enzymes in Chronic Hibernating Myocardium" American Heart Association Scientific Sessions 2007, American Heart Association (2007)
- "Pravastatin Improves Function in Hibernating Myocardium by Restoring Mitochondrial Protein Expression in the Absence of Increased Perfusion" American Heart Association Scientific Sessions 2006, American Heart Association (2006)
- "Myocardial Proteomic Profiling Demonstrates that Overexpressing Fibroblast Growth Factor (AdvFGF-5) Normalizes Metabolic and Stress Protein Expression in Swine with Hibernating Myocardium" American Heart Association Scientific Sessions 2005, American Heart Association (2005)
Service Activities:
- Jacobs School of Medicine & Biomedical Sciences FPMP Governing Board; Member (2018)
- University at Buffalo Fellowship in Cardiovascular Disease Interview Committee; Fellowship in Cardiovascular Medicine Interview Committee; Panel Member (2010–present)
- Buffalo General Medical Center; CCU, Consult services, Non-invasive Cardiology Services (echo, TEE, nuclear imaging).; Clinical Staff (2009–present)