Is It Safe to Take Ibuprofen and Acetaminophen Together? Doctors Explain

John A. Sellick Jr., DO, professor of medicine in the Division of Infectious Diseases, is interviewed about whether people can take ibuprofen and acetaminophen together. If you have a fever or body aches and cycling through ibuprofen and acetaminophen in appropriate doses isn’t helping, you technically can take both medications at once as long as you “dose the drugs carefully and on the correct schedule so that toxicity will be minimized,” Sellick said. “Too much acetaminophen is liver toxic; ibuprofen can be kidney toxic.”