John C. Hu
Residency
Internal Medicine, University at Buffalo
Publications
- Greene, C. J., J. C. Hu, D. J. Vance, Y. Rong, L. Mandell, N. D. King-Lyons, M. Masso-Welch, N. J. Mantis, and T. D. Connell. Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils. Journal of Leukocyte Biology 3A0415-153RR, 2016
- Greene, C. J., L. R. Marks, J. C. Hu, R. Reddinger, L. Mandell, H. Roche-Hakansson, N. D. King-Lyons, T. D. Connell, and A. P. Hakansson. A novel strategy to protect against influenza-induced pneumococcal disease without interfering with commensal colonization. Infection and Immunity 84(6):1693-703. 2016
- Hu, J. C., C. J. Greene, N.D. King-Lyons, and T. D. Connell. The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits. PLoS ONE 10(11):e0142942. 2015
- Hu, J. C., C. Mathias-Santos, C. J. Greene, N. D. King-Lyons, J. F. Rodrigues, G. Hajishengallis, L. C. Ferreira, and T. D. Connell. Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen. PLoS ONE 9:e113978. 2014
- Greene, C. J., C. M. Chadwick, L. M. Mandell, J. C. Hu, J. M. O'Hara, R. N. Brey, 3rd, N. J. Mantis, and T. D. Connell. LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity. PLoS ONE 8:e69678. 2013
- Nawar, H. F., N. D. King-Lyons, J. C. Hu, R. C. Pasek, and T. D. Connell. LT-IIc, a new member of the type II heat-labile enterotoxin family encoded by an Escherichia coli strain obtained from a nonmammalian host. Infection and Immunity 78:4705-4713. 2010
- Hu, J. C., A. Bengrine, A. Lis, and M. S. Awayda. Alternative mechanism of activation of the epithelial Na+ channel by cleavage. The Journal of Biological Chemistry 284:36334-36345. 2009
- Perry, M. J., J. Tait, J. C. Hu, S. C. White, and S. Medler. Skeletal muscle fiber types in the ghost crab, Ocypode quadrata: implications for running performance. The Journal of Experimental Biology 212:673-683. 2009
- Aletta, J. M., and J. C. Hu. Protein arginine methylation in health and disease. Biotechnology Annual Review 14:203-224. 2008
Professional/Educational Meetings/Abstracts
- Differential enhancement of CD8+ T cells by heat-labile enterotoxins LT-IIb and LT-IIc from enterotoxigenic Escherichia coli by intradermal administration American Physician Scientists Association 11th Annual Meeting, Chicago, IL. 2015
- Intradermal administration of the type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen Upstate New York Immunology Conference, Bolton Landing, NY. 2014
- Intradermal administration of type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances both humoral and cellular immunity with minimal inflammation Upstate New York Immunology Conference, Bolton Landing, NY. 2013
- Identification and cloning of LT-IIc, a new Type II heat-labile enterotoxin of Escherichia coli UB Celebration of Excellence, Buffalo, NY. 2008