Eric Irons

eric irons.

Eric Irons

Eric Irons

Residency

Internal Medicine/PSTP, University of Michigan Health System, Ann Arbor, Mich.

Research Publications Overview

Publications

  • Irons E.E., Punch P.R., and Lau J.T. Sialic acid: a central role in the regulation of hematopoiesis and immunity. In preparation. 
  • Irons E.E., Yu T., Cortes Gomez E., Andersen V., and Lau J.T.Y. The role of gastrointestinal sialyltransferase ST6GAL1 in microbiome formation. In preparation.
  • Irons E.E. and Chou R. Autoimmune manifestations in hypermobility type Ehlers-Danlos Syndrome. In preparation. 
  • Weinstock N.I., Shin D., Dhimal N., Hong X., Irons E.E., Silvestri N., Reed C.B., Nguyen D., Bongarzone E., Sampson O., Cheng Y., Lau J.T.Y., Kofler J., Escolar M., Gelb M., Wrabetz L., Feltri M.L. Macrophages expressing GALC improve peripheral Krabbe disease by a mechanism independent of cross-correction. Neuron S0896-6273(20)30238-5 (2020).
  • Irons E.E., Punch P.R., and Lau J.T. Blood-borne ST6GAL1 Regulates Immunoglobulin Production in B cells. Frontiers in Immunology 11:617 (2020).
  • Punch P.R., Irons E.E., Manhardt C.T., Marathe H., and Lau, J.T. ST6Gal-1 deficiency in mice increases radiosensitivity of gastrointestinal epithelial cells resulting in gastrointestinal acute radiation syndrome-like phenotype. Manuscript in preparation. 
  • Irons E.E., Lee-Sundlov M., Zhu Y., Neelamegham S., Hoffmeister K.M., and Lau J.T. B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism. eLife 2019;8e47328 (2019). 
  • Irons E.E. and Lau J.T. Systemic ST6Gal-1 is a Pro-survival Factor for Murine Transitional B cells. Frontiers in Immunology 9:2150 (2018). 
  • Dougher, C.W., Buffone A.J., Nemeth M., Nasirikenari M., Irons E.E., Bogner, P.N., and Lau J.T. The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis. Journal of Leukocyte Biology 102(2): 507-516 (2017). 
  • Di Paolo NC., Baldwin LK., Irons EE., Papayannopoulou T., Tomlinson S., Shayakhmetov DM. IL-1a-IL-1RI-CXCR2 axis and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and elimination of virus-containing cells. PLOS Pathogens 10(3):e 1004035 (2014). 
  • Irons EE., Flatt J., Doronin K., Fox T., Acchione M., Stewart P., Shayakhmetov DM. Coagulation factor binding orientation and dimerization may influence the infectivity of adenovirus-coagulation factor complexes. Journal of Virology 87(17):9610-9 (2013). 
  • Irons EE. Ending Consumption: New Strategies in the Eradication of Tuberculosis in Uzbekistan. University of Washington Bothell Policy Journal, 17: 61-70 (2013).

Professional/Educational Meetings/Abstracts

Oral Presentations 

  • Irons E.E., Cortes Gomez E., Andersen V., and Lau J.T.Y. Intestinal Glycans Shape Microbiome Composition in the Neonatal Period. Roswell Park Microbiome Interest Meeting, Buffalo, NY, July 2019. 
  • Irons E.E., Cortes Gomez E., Andersen V., and Lau J.T.Y. Host ST6Gal-1 Expression Alters the Neonatal Gut Microbiome to Suppress Local and Systemic IL-17 Responses. ASM Microbe 2019, San Francisco, CA, June 2019. 
  • Irons E.E., Punch P.R., and Lau J.T.Y. Extracellular ST6Gal-1 Calibrates B cell IgG production by Cell Non-autonomous Extrinsic Sialylation. Immunology 2019, San Diego, CA, May 2019. 
  • Irons E.E., Cortes Gomez E., Alhammad F., and Lau J.T.Y. Neonatal ST6Gal-1 Expression Alters Microbiome Composition and Mucosal Immunity. 2018 Society for Glycobiology Annual Meeting, New Orleans, LA, November 2018. 
  • Irons E.E., Cortes Gomez E., Andersen V., Alhammad F., and Lau J.T.Y. The Sialyltransferase ST6Gal-1 Directs Early Life Gut Microbiome Colonization and Mucosal Immune Cell Polarization. Upstate MD/PhD Conference, Syracuse, NY, October 2017. 
  • Irons E.E. and Lau J.T.Y. Extrinsic Glycosylation by ST6Gal-1 is a Positive Regulator of Transitional B cell Development. XXXVII World Congress of the International Society of Hematology, Vancouver, BC, September 2018. 
  • Irons E.E. and Lau J.T.Y. Extrinsic Sialylation in the Multiple Myeloma Bone Marrow Microenvironment. InterPEG Future GlycoGen 2017, Bethesda, MD, April 2017. 
  • Atasheva S., Emerson C., Di Paolo N.C., Irons E.E., Gulati N., Stewart P., Shayakhmetov D.M. Functional Role of Adenovirus Penton in Modulating In Vivo Properties of Liver-Targeted and Liver-Detargeted Adenovirus Variants. 19th Annual Meeting of the American Society for Gene and Cell Therapy, Washington D.C., May 2016. 
  • Irons EE., Doronin K., Di Paolo, N., Baldwin, LK., Shayakhmetov DM. Adenovirus Vectors with Large Substitutions in the Penton Base RGD Loop Retain Infectivity and Elicit a Diminished Innate Immune Response in vivo. 17th Annual Meeting of the American Society for Gene and Cell Therapy, Washington D.C., May 2014. 
  • Irons E.E., Flatt J., Doronin K., Fox T., Acchione M., Stewart P., Shayakhmetov D.M. Molecular Modeling of Coagulation FVII Binding to Adenovirus Hexon Revealed a Binding Pocket for Coagulation Factor GLA Domain that Defines the Infectivity of Adenovirus-Coagulation Factor Complexes. 16th Annual Meeting of the American Society for Gene and Cell Therapy, Salt Lake City, UT, May 2013.

Poster Presentations

  • Irons E., Dalziel H., Appenheimer M., Nasirikenari M., Lee-Sundlov M., Manhardt C., Dougher C., Buffone A., Punch P., Jones M., and Lau J. Regulation of Hematopoiesis and Immune Cell Activation by an Extracellular Sialyltransferase. Tri-institutional MD/PhD Research Day, Buffalo, NY, October 2019. 
  • Irons E.E., Cortes Gomez E., Andersen V., and Lau J.T.Y. Host ST6Gal-1 Expression Alters the Neonatal Gut Microbiome to Suppress Local and Systemic IL-17 Responses. ASM Microbe 2019, San Francisco, CA, June 2019. 
  • Irons E.E., Punch P.R., and Lau J.T.Y. Extracellular ST6Gal-1 Calibrates B cell IgG production by Cell Non-autonomous Extrinsic Sialylation. Immunology 2019, San Diego, CA, May 2019. 
  • Irons E.E., Cortes Gomez E., Alhammad F., and Lau J.T.Y. Neonatal ST6Gal-1 Expression Alters Microbiome Composition and Mucosal Immunity. 2018 Society for Glycobiology Annual Meeting, New Orleans, LA, November 2018. 
  • Irons E.E., Cortes Gomez E., Andersen V., Alhammad F., and Lau J.T.Y. The Sialyltransferase ST6Gal-1 Directs Early Life Gut Microbiome Colonization and Mucosal Immune Cell Polarization. Upstate MD/PhD Conference, Syracuse, NY, October 2017. 
  • Irons E.E. and Lau J.T.Y. Regulation of B Lymphocyte Development by Extracellular ST6Gal-1 Sialyltransferase. Immunology 2018, Austin, TX, May 2018. 
  • Irons E.E. and Lau J.T.Y. The Circulatory Sialyltransferase ST6Gal-1 is a Systemic Regulator of Bone Marrow B Lymphopoiesis at the Transitional B cell Stage. AAP/ASCI/APSA Annual Meeting, Chicago, IL, April 2018. 
  • Irons E.E., Nasirikenari M., Yang Y., and Lau J.T.Y. Regulation of Peripheral B cell Development by ST6Gal-1. APSA Northeast Regional Meeting, Rochester, NY, October 2017. 
  • Irons E.E. and Lau J.T.Y. Extrinsic Sialylation in the Multiple Myeloma Bone Marrow Microenvironment. InterPEG 2017, Bethesda, MD, April 2017. 
  • Irons E.E. and Lau J.T.Y. Extrinsic Sialylation in the Multiple Myeloma Bone Marrow Microenvironment. Medical Scientist Research Symposium, Rochester, NY, April 2017. 
  • Irons E.E., Lee-Sundlov M., Manhardt C., and Lau J.T.Y. B cell Contributions to Circulatory ST6Gal-1. APSA Northeast Regional Meeting, Buffalo, NY, October 2016. 
  • Irons E.E., Stewart P.L., Shayakhmetov D.M. Blood Coagulation Factors in Disseminated Adenovirus Infection: How Structural Differences Define Biological Tropism and Immune Response. Tri-institutional MD/PhD Program Conference, Rochester, NY, October 2014.
  • Irons E.E, Stewart P.L., Shayakhmetov D.M. Structural Aspects of Coagulation Factor VII Binding to Adenovirus Serotype 5. University of Washington Undergraduate Research Symposium, Seattle, WA, May 2013.