Jiho Sohn

Jiho Sohn.

Jiho Sohn

Jiho Sohn

Residency

Internal Medicine/PSTP, University of Texas Southwestern Medical Center, Dallas, Texas

Research Publications Overview

Publications

  • Sohn J*, Li L, Zhang L, Falkner KL, Tettelin H, Rowsam A, Smiraglia D, Novak JM, Diaz PI, Sun Y, Kirkwood KL. Periodontal disease is associated with increased oral-gut transmission of pathogenic Haemophilus parainfluenzae in Crohn’s disease patients. (Manuscript under review) *Corresponding author
  • Li L, Sohn J, Genco RJ, Wactawski-Wende J, Goodison S, Diaz PI, Sun Y. Computational approach to modeling microbiome landscapes associated with chronic human disease progression. PLOS Computational Biology. 2022;18(8):e1010373.
  • Zhang L, Kirkwood CL, Sohn J, Lau A, Bayers-Thering M, Bali SK, Rachala S, Marzo JM, Anders MJ, Beier F, Kirkwood KL. Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling. Arthritis Research & Therapy. 2021;23(1):287.
  • Sohn J, Li L, Zhang L, Settem RP, Honma K, Sharma A, Falkner KL, Novak JM, Sun Y, Kirkwood KL. Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4(+) T cells. Mol Oral Microbiol. 2021.
  • Li Z, Zhang L, Liu F-y, Li P, He J, Kirkwood CL, Sohn J, Chan JM, Magner WJ, Kirkwood KL. MKP-1 is required to limit myeloid-cell mediated oral squamous cell carcinoma progression and regional extension. Oral Oncology. 2021;120:105401.
  • Sohn J, Sun Y, Genco RJ et al. The Periodontal Microenvironment: a Potential Reservoir for Intestinal Pathobionts in Crohn’s Disease. Curr Oral Health Rep 7, 37–44 (2020). 
  • Cox LM, Schafer MJ, Sohn J et al. Calorie restriction slows age-related microbiota changes in an Alzheimer’s disease model in female mice. Sci Rep 9, 17904 (2019).
  • Cox LM, Sohn J, Tyrrell KL, Citron DM, Lawson PA, Nisha PB, Iizumi T, Perez-Perez GI, Goldstein EC, Blaser MJ. Description of two novel members of the family Erysipelotrichaceae: Ileibacterium lipovorans gen. nov., sp. nov. and Dubosiella newyorkensis, gen. nov., sp. nov.  IJSEM 2017
  • Llorca L, Pérez GP, Urruzuno P, Martínez J, Iizumi T, Gao Z, Sohn J, Chung J, Cox L, Simón-Soro A, Mira A, Alarcón T. Characterization of the gastric microbiota in a pediatric population according to Helicobacter pylori status. Pediatric Infectious Disease Journal. 2016 36 (2), 173-178
  • Livanos AE, Greiner T, Vangay P, Pathmasiri W, Stewart D, McRitchie S, Li H, Chung J, Sohn J, Gao Z, Barber C, Kim S, Kim J, Ng S, Rogers A, Sumner S, Knights D, Alekseyenko A, Bäckhed F, Blaser MJ. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in NOD mice. Nature Microbiology, doi:10.1038/nmicrobiol.2016.140.
  • Nobel YR, Cox LM, Kirigin FF, Bokulich NA, Yamanishi S, Teitler I, Chung J, Sohn J, Barber CM, Goldfarb DS, Raju K, Abubucker S, Zhou Y, Ruiz VE, Li H, Mitreva M, Alekseyenko AV, Weinstock GM, Sodergren E, Blaser MJ. Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nature Communication. 2015;6.
  • Cox LM, Yamanishi S, Sohn J, Alekseyenko Alexander V, Leung Jacqueline M, Cho I, Kim Sungheon G, Li H, Gao Z, Mahana D, Zárate Rodriguez Jorge G, Rogers Arlin B, Robine N, Loke Pn, Blaser Martin J. Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences. Cell. 2014 158(4):705-721.

Professional/Educational Meetings/Abstracts

  • Sohn J, Li L, Zhang L, Falkner KL, Tettelin H, Rowsam A, Smiraglia D, Novak JM, Diaz-Moreno P, Sun Y, Kirkwood KL. Periodontal disease increases oral-gut transmission of colitogenic Haemophilus parainfluenzae in Crohn’s disease patients. Digestive Disease Week; 2022; San Diego CA.
  • Sohn, Jiho, Lu Li, Lixia Zhang, Rajendra P. Settem, Kiyonobu Honma, Ashu Sharma, Karen L. Falkner, Jan M. Novak, Yijun Sun, and Keith L. Kirkwood. "606 Porphyromonas gingivalis-altered gut microbiota induces small intestinal IL9+CD4+ lymphocyte expansion and ileal inflammation." Gastroenterology 160, no. 6 (2021): S-119.
  • Sohn, J. Sun, Y. Genco, R.J. Kirkwood, K.L. (2019) Unraveling the Mechanistic Relationship Between Periodontal Disease and Inflammatory Bowel Disease. JCVI/AADR Fall Focused Symposium: Integrating Omic Datasets Towards Translation. La Jolla, CA
  • Sohn, J. Settem, P.R. Homma, K. Li, L. Sharma, A. Sun, Y. Genco, R.J. Kirkwood, K.L. (2019) The potential role of periodontopathogens in inflammatory bowel disease. The 4th Penn Periodontal Conference. Philadelphia, PA. 
  • Sohn, J. Settem, P.R. Homma, K. Li, L. Falkner, K.L. Novak, J.M. Sharma, A. Sun, Y. Genco, R.J. (2019) Understanding the role of oral microbiota in the pathogenesis of Crohn’s disease. UB Genetics, Genomics, and Bioinformatics Annual Research Day. Buffalo, NY.
  • Li, L. Sohn, J. Sun, Y. Genco, R.J. Buffalo OsteoPerio Microbiome Study Group (2017). Exploring dynamics of the human gut microbiome in Crohn’s disease. UB Communities of Excellence Conference. Buffalo, NY
  • Sohn, J. Sun, Y. Genco, R.J. (2017). Using salivary microbiome data to detect type II diabetes and myocardial infarction in patients with underlying periodontal disease. UB Genetics, Genomics, and Bioinformatics Annual Research Day. Buffalo, NY.
  • Sohn, J. Sun, Y. Genco, R.J. (2017). Using salivary microbiome data to detect type II diabetes and myocardial infarction in patients with underlying periodontal disease. Annual Jacobs School of Medicine and Biomedical Sciences Medical Student Research Forum. Buffalo, NY.
  • Sohn, J. Shahab, D. Alnaji, R.M. Lackner, J.M. (2016). Using gut microbiota profile to predict outcome of cognitive behavior therapy for irritable bowel syndrome. Jacobs School of Medicine and Biomedical Sciences Fourth Annual Department of Medicine Research Day. Buffalo, NY
  • Sohn, J. Cox, L.M. Blaser, M.J. (2016). Early life disruption of microbiota in mice leads to long-lasting metabolic consequences. Annual Jacobs School of Medicine and Biomedical Sciences Medical Student Research Forum. Buffalo, NY.
  • Sohn, J. Elkins, L.P. (2016). Effect of proton pump inhibitor treatment on oral microbiota. GEM Microbiome Workshop. Buffalo, NY.
  • Sohn, J. Cox, L.M. Yamanishi, S. Mahana, D. Zárate, J.Z. Blaser, M.J. (2014). Administering sub-therapeutic antibiotic treatment and high fat diet leads to synergistic increase in obesity. 13th NYU School of Medicine Research Day. New York, NY.
  • Sohn, J. Cox, L.M. Blaser, M.J. (2013). Synergistic effect of sub- therapeutic antibiotic treatment and high fat diet in microbe induced obesity. The New York Academy of Science, The Microbiome in Health, Disease, and Therapeutics: Bugs, Guts and Drugs. New York, NY.
  • Sohn, J. Cox, L.M. Raju, K. Zárate, J.Z. Blaser, M.J. (2013). Early life microbiome disruption alters juvenile metabolism and results in adult obesity. 12th NYU School of Medicine Rearch Day. New York, NY.
  • Sohn, J. Cox, L.M. Raju, K. Zárate, J.Z. Blaser, M.J. (2013). Early life microbiome disruption alters juvenile metabolism and results in adult obesity. 39th NYU Undergraduate Research Conference. New York, NY.