James A. Fallavollita MD

James Fallavollita

James A. Fallavollita
MD

Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Cardiology; Cardiovascular Disease; Metabolism

Contact Information
Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, New York 14203
Phone: 716-829-2663
Fax: 716-854-1840
jaf7@buffalo.edu
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Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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Overview Research Publications Activities Latest News

Professional Summary:

My clinical activities as a noninvasive cardiologist primarily take place at the Buffalo VA Medical Center (VAMC). My responsibilities include attending on the inpatient cardiology consultation service and interpreting echocardiograms, stress tests and electrocardiograms (EKGs).

My research career initially focused on translational research using porcine models to investigate physiologic and metabolic adaptations that result from acute and chronic myocardial ischemia (chronically stunned and hibernating myocardium). These preclinical investigations have led to clinical research, including the recent completion of an NIH-sponsored clinical trial. This trial, on which I am the co-principal investigator with John M. Canty, Jr., MD, proved that the presence of sympathetically denervated myocardium quantified by positron emission tomography can predict the risk of sudden death in patients with ischemic cardiomyopathy. I am in the process of extending these findings to the clinical management of patients with implantable cardiac defibrillators.

My work as a physician-scientist has included serving on numerous research-related oversight committees and as a peer reviewer for multiple national, regional and local committees. I have been funded by the National Institutes of Health (NIH), the Department of Veterans Affairs and the American Heart Association to conduct a variety of investigator-initiated research projects.

Medical education is a critical component of my professional life. Nearly all of my clinical and research activities are performed in conjunction with the education of fellows in cardiovascular diseases, residents in internal medicine and medical students. I facilitate small group sessions for second-year medical students in Cardiovascular Physiology for which I have earned several commendations for teaching excellence; I am gratified to have participated in the education of hundreds of young physicians. I have also published dozens of abstracts and manuscripts with various levels of trainees, giving them the opportunity to grow as physician-scientists while at the same time advancing medical knowledge.

Education and Training:
  • MD, University of Washington School of Medicine (1987)
  • BS, University of Washington (1983)

Employment:
  • Professor of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2007-present)
  • Staff Cardiologist, Buffalo Veterans Affairs Medical Center (1994-present)
  • Program Director, Cardiovascular Disease Fellowship, University at Buffalo (2007–2008)
  • Associate Professor of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001–2006)
  • Assistant Professor of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998–2001)
  • Research Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1994–1998)
  • Research Clinical Fellow, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1991–1994)
  • Clinical Assistant Instructor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1990–1993)
  • Internship and Residency, University at Rochester (1987–1990)

Awards and Honors:
  • Best Paper in Circulation: Cardiovascular Imaging (2018)
  • Outstanding Research, Department of Medicine (2014)
  • Commendations for Teaching Excellence (2011)
  • University at Buffalo School of Nursing Dean's Mentor Award (2008)
  • Fellowship, American College of Physicians (2002)
  • Fellowship, American Heart Association (2001)
  • Young Investigator Award to attend the European Society of Cardiology Conference (1999)
  • Travel Award, 4th Annual Astra Merck Cardiovascular Young Investigator Forum (1998)
  • Fellowship, American College of Cardiology (1997)
  • Clinician Scientist Award, American Heart Association (1996)
  • Young Investigator Award, NYS ACC (1994)
  • John C. Sable Memorial Heart Fund Grant, Independent Order of Oddfellows (1993)
  • Commissioned Officer Student Training and Extern Program. US Public Health, Bethesda, MD (1985)

Research Expertise:
  • Chronic adaptations to myocardial ischemia
  • Sudden cardiac death

Grants and Sponsored Research:
  • November 2016–December 2021
    Prediction of Arrhythmic Events with Positron Emission Tomography - II (PAREPET II)
    National Heart Lung and Blood Institute - NHLBI
    Role: Co-Principal Investigator
    $3,726,616
  • January 2016–December 2021
    Prediction ARrhythmic Events with Positron Emission Tomography - II (PAREPET-II)
    NIH - NHLBI
    Role: Co-Principal Investigator
  • January 2016–December 2019
    VA Merit Review, Dynamic remodeling from reversible ischemia and sudden cardiac arrest
    VA
    Role: Co-Investigator
    $649,600
  • July 2013–June 2015
    T3np for Cardiac Resuscitation - Pivotal Pre-Clinical Trial
    UB CAT/Pro-Al Medico Technologies
    Role: Co-Investigator
  • April 2004–June 2011
    2004-2009 Hibernating Myocardium and Sudden Cardiac Death
    National Heart Lung and Blood Institute
    Role: Co-Principal Investigator

Journal Articles:

  • Biddle C, Fallavollita JA, Homish GG, Giovino GA, Orom H. (2020) Gender differences in symptom misattribution for coronary heart disease symptoms and intentions to seek health care. Women Health (Apr), 60(4): 367-381.
  • Wang, X, Moody, J, Kaps, N, Britt, D, Lavallee, A, Renaud, J, Zelt, J, Wu, K, Beanlands, R, Fallavollita JA, Canty J. (2020) Reproducible Quantification of Regional Sympathetic Denervation with [11C] meta-Hydroxyephedrine PET Imaging. Journal of Nuclear Cardiology (Apr).
  • Suzuki G, Weil BR, Young, Rebeccah, Fallavollita JA, Canty J. (2019) Nonocclusive Multivessel Intracoronary Infusion of Allogeneic Cardiosphere-derived Cells Early After Reperfusion Prevents Remote Zone Myocyte Loss and Improves Global Left Ventricular Function in Swine with Myocardial Infarction. Am J Physiol Heart Circ Physiol (Aug), 317(2): H345-H356.
  • Biddle C, Fallavollita JA, Homish GG, Orom H. (2019) Gender bias in clinical decision making emerges when patients with coronary heart disease symptoms also have psychological symptoms. Heart Lung (Jul), 48(4): 331-338.
  • Suzuki G, Weil BR, Young, R, Fallavollita JA, Canty J. (2019) Non-occlusive Multi-Vessel Intracoronary Infusion of Allogeneic Cardiosphere-Derived Cells Prevents Remote Zone Myocyte Loss in Swine and Myocardial Infarction. American Journal of Physiology. (Heart and Circ Physiology) (Jan), 312(2): 345-356.
  • Al-Zaiti SS, Pietrasik G, Carey MG, Alhamaydeh M, Canty JM, Fallavollita JA. (2019) The role of heart rate variability, heart rate turbulence, and deceleration capacity in predicting cause-specific mortality in chronic heart failure. J Electrocardiol (Jan), 52: 70-74.
  • Fallavollita JA, Dare, JD, Carter, RL, Baldwa S, Canty J. (2017) Denervated myocardium preferentially predicts sudden cardiac arrest in ischemic cardiomyopathy: A competing risk analysis of cause-specific mortality. Circulation: Cardiovascular Imaging (Aug), 10(8).
  • Fallavollita JA, JD Dare, RL Carter, S Baldwa and JM Canty Jr. (2017) Denervated myocardium is preferentially associated with sudden cardiac arrest in ischemic cardiomyopathy. A pilot competing risks analysis of cause-specific mortality. Circ Cardiovascular Imaging (Jan), 10: e0064.
  • Chaudhari M, JA Fallavollita and GA Farkas. (2016) The effects of experimental sleep apnea on cardiac and respiratory functions in 6 and 18 month old dystrophic (mdx) mice. PLoS One (Jan).
  • Al-Zaiti SS, Fallavollita JA, Canty, Jr. JM, Carey MG. (2015) The prognostic value of discordant T waves in lead aVR: A simple risk marker of sudden cardiac arrest in ischemic cardiomyopathy. J Electrocardiol (Sep), 17(8): 887-892.
  • Weil BR, Suzuki G, Leiker MM, Fallavollita JA, Canty, Jr. JM. (2015) Comparative efficacy of intracoronary allogeneic mesenchymal stem cells and cardiosphere derived cells in swine with hibernating myocardium. Circulation Research (Sep), 117: 634-644.
  • Malhotra S, Fernandez SF, Fallavollita JA, Canty JM. (2015) Prognostic significance of imaging myocardial sympathetic innervation. Curr Cardiol Rep (Aug), 17(8): 62-62.
  • Page BJ, Banas MD, Suzuki G, Weil BR, Young RF, Fallavollita JA, Palka BA and Canty JM Jr. (2015) Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. J Am College Card (Jan), 65(7): 684-697.
  • Qu J, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM. (2014) Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models. J Proteome Res (May), 13(5): 2571-2584.
  • Fallavollita JA, Heavey BM, Luisi AJ Jr, Michalek SM, Baldwa S, Mashtare TL, Hutson AD, deKemp RA, Haka MS, Sajjad M, Cimato TR, Curtis AB, Cain ME and Canty JM Jr. (2014) Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol (Jan), 63: 141-149.
  • Al-Zaiti SS, JA Fallavollita, YB Wu, MR Tomita and MG Carey. (2014) Electrocardiogram-based predictors of clinical outcomes: A meta-analysis of the prognostic value of ventricular repolarization. Heart & Lung: The Journal of Acute and Critical Care (Jan), 43: 516-526.
  • Al-Zaiti SS, Fallavollita JA, Canty JM Jr and Carey MG. (2014) Electrocardiographic predictors of sudden and non-sudden cardiac death in patients with ischemic cardiomyopathy. Heart Lung: Journal of Acute and Critical Care (Jan), 43: 527-533.
  • Fernandez SF, Ovchinnikov V, Canty JM, Fallavollita JA. (2013) Hibernating myocardium results in partial sympathetic denervation and nerve sprouting. Am J Physiol Heart Circ Physiol (Jan), 304(2): 318-327.
  • Pizzuto MF, Suzuki G, Banas MD, Heavey B, Fallavollita JA and Canty JM. (2013) Dissociation of hemodynamic and electrocardiographic indices of myocardial ischemia in pigs with hibernating myocardium and sudden cardiac death. Am. J. Physiol. Heart Circ. Physiol. (Jan), 304: 1697-1707.
  • Pizzuto MF, Suzuki G, Banas M, Heavey B, Fallavollita JA and Canty JM, Jr. (2013) Dissociation of hemodynamic and electrocardiographic indices of myocardial ischemia in pigs with hibernating myocardium and sudden cardiac death. Am J Physiol Heart Circ Physiol (Jan), 304: H1697-H1707.
  • Fernandez SF, Ovchinnikov V, Canty JM Jr, Fallavollita JA. (2013) Hibernating Myocardium Results in Partial Sympathetic Denervation and Nerve Sprouting. Am J. Physiol Heart Circ Physiol (Jan), 304: H318-H327.
  • Canty, Jr. JM. (2013) "The role of short QT interval and elevated LV end-diastolic pressure in the genesis of ventricular tachycardia and fibrillation.". Am. J. Physiol. Heart Circ. Physiol. (Jan).
  • Page BJ, Young RF, Suzuki G, Qu J, Fallavollita JA. (2013) The physiological significance of a coronary stenosis differentially affects contractility and mitochondrial function in viable chronically dysfunctional myocardium. Basic Research in Cardiology (Jan), 108: 354-370.
  • Cary MG, AJ Luisi Jr,, S Baldwa, MJ Veneziano, S Al-Zaiti, RA deKemp, JM Canty Jr and JA Fallavollita. (2010) The Selvester QRS Score is More Accurate than Q Waves and Fragmented QRS Complexes using the Mason-Likar Configuration in Estimating infarct Volume in Patients with Ischemic Cardiomyopathy. J Electrocardiology (Jan), 43: 318-325.
  • Fallavollita JA, Banas MD, Suzuki G, deKemp RA, Sajjad M, Canty JM. (2010) 11C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium. J Nucl Cardiol (Jan), 17(1): 85-96.
  • Fallavollita JA, Luisi AJ Jr, Yun E, deKemp RA and Canty JM Jr. (2010) An abbreviated hyperinsulinemic-euglycemic clamp results in similar myocardial glucose utilization in both diabetic and non-diabetic patients with ischemic cardiomyopathy. Journal of Nuclear Cardiology (Jan), 17: 637-645.
  • Fallavollita JA, Canty J. (2010) Dysinnervated by Viable Myocardium in Ischemic Heart Disease. J. Nucl. Cardiol. (Jan), 17: 1107-1115.
  • Hu Q, Suzuki G, Young RF, Page BJ, Fallavollita JA, Canty JM. (2009) Reductions in mitochondrial O(2) consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium. Am J Physiol Heart Circ Physiol (Jul), 297(1): 223-232.
  • Fallavollita JA. (2009) Determinants of delayed preconditioning against myocardial stunning in chronically-instrumented pigs. J Cardiovasc Transl Res (Jan), 2: 71-80.
  • Baldwa S, Rana M, Canty JM Jr and Fallavollita JA. (2008) Comparison of thallium and insulin-stimulated FDG deposition in pigs with chronic hibernating myocardium. Am J Physiol: Heart and Circulatory Physiology (Jan), 295: H2522-H2529.
  • Page B, Young R, Iyer V, Suzuki G, Lis M, Korotchkina L, Patel MS, Blumenthal KM, Fallavollita JA, Canty JM Jr. (2008) Persistent Regional Downregulation in Mitochondrial Enzymes and Upregulation of Stress Proteins in Swine with Chronic Hibernating Myocardium. Circulation Research (Jan), 102: 103-112.
  • Sidhu S, A Gangasani, LB Korotchkina, G Suzuki, JA Fallavollita, JM Canty and MS Patel. (2008) Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice. Am. J. Physiol. Heart Circ. Physiol. (Jan), 295: 946-952.
  • Carey MG, Luisi AJ, Baldwa S, Thomas JM, Canty JM, Fallavollita, JA. (2007) The presence of Q Waves, QRS Fragmerntation or QRS Duration does not correlate with scar volume in patients with ischemic cardiomyopathy circulation. Circulation (Jan), 116.
  • Lynch P, Lee TC, Fallavollita JA, Canty JM Jr, Suzuki G. (2007) Intracoronary administration of AdvFGF-5 (Fibroblast Growth Factor-5) ameliorates left ventricular dysfunction and prevents myocyte loss in swine with developing collaterals and ischemic cardiomyopathy. Circulation. (Jan), 116: 71-76.
  • Banas MD, Baldwa S, Suzuki G, Canty JM Jr, Fallavollita JA. (2007) Determinants of contractile reserve in viable, chronically dysfunctional myocardium. American Journal of Physiology Heart Circulatory Physiology. (Jan), 292(6): 2791-2797.
  • Fallavollita JA, Luisi AJ, Michalek SM, Valverde AM, deKemp RA, Haka MS, Hutson AD, Canty JM. (2006) Prediction of arrhythmic events with positron emission tomography: PAREPET study design and methods. Contemp Clin Trials (Aug), 27(4): 374-388.
  • Banas, M.D. Young, H. Fallavollita, J.A. Canty, J.M., Jr. (2006) Persistent reductions in flow and function after revascularization of swine with hibernating myocardium. Journal of the American College of Cardiology (Jan).
  • Canty, Jr. JM. (2006) Brief sympathetic activation precedes the development of VT/VF in hibernating myocardium. J. Electrocardiol (Jan), 39: 140-145.
  • Ovchinnikov V, Suzuki G, Canty JM, Fallavollita JA. (2005) Blunted functional responses to pre- and postjunctional sympathetic stimulation in hibernating myocardium. Am J Physiol Heart Circ Physiol (Oct), 289(4): 1719-1728.
  • Luisi AJ, Suzuki G, Dekemp R, Haka MS, Toorongian SA, Canty JM, Fallavollita JA. (2005) Regional 11C-hydroxyephedrine retention in hibernating myocardium: chronic inhomogeneity of sympathetic innervation in the absence of infarction. J Nucl Med (Aug), 46(8): 1368-1374.
  • Fallavollita, J.A. Riegel, B.J. Suzuki, G. Valeti, U. Canty, J.M., Jr. (2005) Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy. American Journal of Physiology - Heart & Circulatory Physiology (Jan), 289: H2688-H2696.
  • Luisi AJ Canty, J.M., Jr. deKemp, R.A. Haka, M.S. Toorongian, S.A. Fallavollita, J.A. (2005) Patients with ischemic cardiomyopathy eligible for ICD therapy demonstrate extensive sympathetic denervation out of proportion to previous infarction. Circulation (Jan), 112: 472-472.
  • Gangasani, A. Sidhu, S. Fallavollita, J.A. Korotchkina, L. G. Suzuki, G. Patel, M.S. Canty, J.M., Jr. (2005) Cardiac pyruvate dehydrogenase complex (PDC) deficiency in mice leads to myocardial hypertrophy and cardiomyopathy. Circulation (Jan), 112(II): II-21-II-22.
  • Suzuki, G Lee, TC Fallavollita, JA Canty, JM, Jr. (2005) Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle. Circulation Research (Jan), 96: 767-775.
  • Canty, J. M. Fallavollita, J. A. (2005) Hibernating myocardium. J Nucl Cardiol (Jan), 12(1): 104-119.
  • Luisi AJ Fallavollita, J.A. Luisi, A.J. Valverde, A.M. Michalek, S.M. Heavey, B.M. Canty, J.M. (2005) Electrocardiographic risk stratification of sudden cardiac death. J Electrocardiol (Jan), 35(4S): 140-140.
  • Fallavollita JA, Valeti U, Oza S, Canty JM. (2004) Spatial heterogeneity of endocardial voltage amplitude in viable, chronically dysfunctional myocardium. Basic Res Cardiol (May), 99(3): 212-222.
  • Canty JM, Suzuki G, Banas MD, Verheyen F, Borgers M, Fallavollita JA. (2004) Hibernating Myocardium. Chronically Adapted to Ischemia but Vulnerable to Sudden Death. Circ Res (Mar).
  • Thijssen VL, Borgers M, Lenders MH, Ramaekers FC, Suzuki G, Palka B, Fallavollita JA, Thomas SA, Canty JM Jr. (2004) Temporal and Spatial Variations in Structural Protein Expression During the Progression From Stunned to Hibernating Myocardium. Circulation (Jan), 110(21): 2213-2221.
  • Canty JM, Fallavollita JA. (2003) Sympathetic nerves and myocyte necrosis: more than meets the eye. Circ Res (Oct), 93(9): 796-798.
  • Fallavollita JA, Malm BJ, Canty JM. (2003) Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest. Circ Res (Jan), 92(1): 48-55.
  • Malm BJ, Suzuki G, Canty JM, Fallavollita JA. (2002) Variability of contractile reserve in hibernating myocardium: dependence on the method of inotropic stimulation. Cardiovasc Res (Dec), 56(3): 422-432.
  • Thomas SA, Fallavollita JA, Suzuki G, Borgers M, Canty JM. (2002) Dissociation of regional adaptations to ischemia and global myolysis in an accelerated Swine model of chronic hibernating myocardium. Circ Res (Nov), 91(10): 970-977.
  • Fallavollita JA, Logue M, Canty JM. (2002) Coronary patency and its relation to contractile reserve in hibernating myocardium. Cardiovasc Res (Jul), 55(1): 131-140.
  • Fallavollita JA, Canty JM. (2002) Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium. Am J Physiol Heart Circ Physiol (Apr), 282(4): 1370-1379.
  • Luisi AJ, Fallavollita JA, Suzuki G, Canty JM. (2002) Spatial inhomogeneity of sympathetic nerve function in hibernating myocardium. Circulation (Jan), 106(7): 779-781.
  • Fallavollita JA, Lim H, Canty JM. (2001) Myocyte apoptosis and reduced SR gene expression precede the transition from chronically stunned to hibernating myocardium. J Mol Cell Cardiol (Nov), 33(11): 1937-1944.
  • Canty JM, Fallavollita JA. (2001) Lessons from experimental models of hibernating myocardium. Coron Artery Dis (Aug), 12(5): 371-380.
  • Fallavollita JA, Logue M, Canty JM. (2001) Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve. J Am Coll Cardiol (Jun), 37(7): 1989-1995.
  • Feng J, Schaus BJ, Fallavollita JA, Lee T, Canty, Jr. JM. (2001) Preload induces troponin I degradation independently of myocardial ischemia. Circulation (Apr), 103(16): 2035-2037.
  • Fallavollita JA, Logue M, Canty JM. (2001) Stability of hibernating myocardium in pigs with chronic LAD stenosis: Absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve. J Am Coll Cardiol, (Jan), 37: 1989-1995.
  • Pizzuto MF, AM Valverde, BM Heavey, MD Basnas, N Michelakis, G Suzuki, JA Fallavollita and JM Canty Jr. (2001) Brief sympathetic activation precedes the development of VT/VF in reductions in flow, function and coronary flow reserve. J. Am. .Coll. Cardiol (Jan), 37: 1989-1995.
  • Fallavollita JA, Trojan C, Canty JM. (2000) Transmural distribution of FDG uptake in stunned myocardium. Am J Physiol Heart Circ Physiol (Jul), 279(1): 102-109.
  • Canty JM, Fallavollita JA. (2000) Chronic hibernation and chronic stunning: a continuum. J Nucl Cardiol (Jan), 7(5): 509-527.
  • Lim H, Fallavollita JA, Hard R, Kerr CW, Canty JM. (1999) Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium. Circulation (Dec), 100(23): 2380-2386.
  • Fallavollita JA, Jacob S, Young RF, Canty JM. (1999) Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium. Am J Physiol (Oct), 277(4 Pt): 1418-1428.
  • Thomas SA, Fallavollita JA, Lee T, Feng J, Canty, Jr. JM. (1999) Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine. Circ Res (Sep), 85(5): 446-456.
  • Canty JM, Fallavollita JA. (1999) Resting myocardial flow in hibernating myocardium: validating animal models of human pathophysiology. Am J Physiol (Jul), 277(1 Pt): 417-422.
  • Fallavollita JA, Canty JM. (1999) Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs. Circulation (Jun), 99(21): 2798-2805.
  • Fallavollita JA, Perry BJ, Canty JM. (1997) 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium. Circulation (Apr), 95(7): 1900-1909.
  • Fallavollita JA, BJ Perry and JM Canty Jr. (1997) F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium: Evidence for transmural variations in chronic hibernating myocardium. Circulation (Jan), 95: 1900-1909.
  • Fallavollita JA, Kumar K, Brody AS, Bunnell IL, Canty JM. (1996) Detection of coronary artery calcium to differentiate patients with early coronary atherosclerosis from luminally normal arteries. Am J Cardiol (Dec), 78(11): 1281-1284.
  • Canty JM, Fallavollita JA. (1995) Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis. Basic Res Cardiol (Jan), 90(1): 5-8.
  • Fallavollita JA, Brody AS, Bunnell IL, Kumar K, Canty JM. (1994) Fast computed tomography detection of coronary calcification in the diagnosis of coronary artery disease. Comparison with angiography in patients < 50 years old. Circulation (Jan), 89(1): 285-290.
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Books and Book Chapters:

  • Fernandez SF, Canty JM, Fallavollita J. (2017) Atlas of Cardiac Innervation. In: PET imaging and quantitation of cardiac innervation. Spring International Publishing, 71-82.
  • Canty, Jr.; Fallavollita J. (2010) In: Pathophysiological basis of hibernating myocardium. , 577-593.

Abstracts:

  • Wang, JZ, Kaps, N, Lavallee, A, Renaud, J, Zelt, J, Beanlands, R, Fallavollita JA, Canty J, deKemp, R. (2019) Quantitative imaging biomarkers of cardiac sympathetic innervation and perfusion using C-11-metahydroxyephedrine and N-13-ammonia PET in ischemic cardiomyopathy. International Congress of Nuclear Cardiology and Cardiac CT, (May)
  • Wang, JZ, Kaps, N, Lavallee, A, Renaud, J, Zelt, J, Beanlands, R, Fallavollita JA, Canty J, deKemp, R. (2019) Comparison of C-11-meta-hydroxyephedrine and N-13-ammonia PET imaging biomarkers of cardiac sympathetic innervation and perfusion in ischemic cardiomyopathy. Journal Nucelar Medicine, (Jan)
  • Singh V, Malhotra S, Canty J, Fallavollita JA. (2018) The volume of denervated myocardium predicts sudden cardiac death (SCD) and ICD therapies for VF but not ICD therapies for slower ventricular tachyarrhythmia (VT): An analysis of the prediction of arrhythmic events with positron emission tomography (PARE. Journal of the American College of Cardiology, (May)
  • Carey MG, Fallavollita JA, Canty JM Jr, Al-Zaiti SS. (2013) ECG predictors of mortality among implantable cardioverter-defibrillator candidates for the primary prevention of sudden cardiac death. J Am Coll of Card, (Jan) E616
  • Fallavollita JA, Pietrasik G, Canty J. (2013) Myocardial sympathetic denervation by PET identifies a substrate for sudden cardiac arrest but not slow ventricular tachycardia (<240 BPM) in patients with ischemic cardiomyopathy. J Am Coll of Card, (Jan) E1004
  • Pietrasik G, JM Canty and JA Fallavollita. (2012) Deceleration capacity, not heart rate turbulence, predicts sudden cardiac death in high-risk patients with ischemic cardiomyopathy. Heart Rhythm Journal, (Jan)
  • Fallavollita J, BM Heavey, S Baldwa, TL Mashtare Jr, AD Hutson, M Sajjad, RA deKdemp, AB Curtis, ME Cain and JM Canty Jr. (2012) Volume of denevated myocardium is a novel predictor of VT/VF: Prediction of arrhythmic events with positron emission tomography (PAREPET) study. Heart Rhythm Journal, (Jan)

Professional Memberships:
  • Fellow, American Heart Association; Councils on Clinical Cardiology and Basic Cardiovascular Sciences.; Fellow, American Heart Association; Councils on Clinical Cardiology and Basic Cardiovascular Sciences. (1994–present)
  • Fellow, American College of Cardiology; Fellow, American College of Cardiology (1992–present)
  • Fellow, American College of Physicians; Fellow, American College of Physicians (1990–present)

Service Activities:
  • Jacobs School of Medicine and Biomedical Sciences Curriculum Committee; Member (2016–2017)
  • University at Buffalo-Faculty Council Bi-Decanal Promotion and Tenure Committee; Member (2014)
  • Graduate Faculty; Member (2014–present)
  • UB Social and Behavioral Sciences Institutional Review Board; Member (2013)
  • School of Medicine and Biomedical Engineering Faculty Search Committee; Member (2011–2017)
  • UB President's Review Board; Member (2011–2014)
  • UB Clinical and Translational Center Pilot Grant Review and Oversight Committee; Member (2011–2012)
  • NIH, Ad hoc reviewer, NIH Director’s Early Independence Award NIH, Ad hoc reviewer, NIH Director’s Early Independence Award; Ad Hoc Reviewer (2011)
  • University at Buffalo School of Medicine and Biomedical Sciences Mentoring Committee; Member (2011–present)
  • UB Health Sciences Institutional Review Board; Ad hoc Member; Member (2010–2015)
  • Department of Biomedical Engineering Faculty Search Committee; Member (2010–2011)
  • NIH, Ad hoc member, Small Business: Cardiovascular Sciences Study Section NIH, Ad hoc member, Small Business: Cardiovascular Sciences Study Section; Panel Member (2010)
  • UB Institutional Biosafety Committee; Member (2009–2016)
  • UB Clinical and Translational Research Center Planning Committees (Imaging, Cyclotron, Laboratory and Biostatistics Sub-committees; Member (2009–2010)
  • UB Recovery Act Limited Competition Internal Review Panel; Member (2009–present)
  • Search Committee, Laboratory Animal Research Compliance Administrator; Member (2008)
  • MS Thesis Committee, Dept. of Biostatistics; Member (2008)
  • University at Buffalo-Radioactive Drug Research Committee; Member (2008–present)
  • NIH, Chair, Cardiovascular Sciences Special Emphasis Panel NIH, Chair, Cardiovascular Sciences Special Emphasis Panel; Chair (2007)
  • UB Nomination Committee, NYSTAR JD Watson Award; Member (2007)
  • American College of Physicians; Program Planning Committee; NY Upstate Scientific Meeting; Member (2006)
  • Department of Nuclear Medicine Research and Development Division; Member (2005–2010)
  • NIH, Member, Clinical & Integrative Cardiovascular Sciences Study Section Member, Clinical & Integrative Cardiovascular Sciences Study Section; Ad Hoc Reviewer (2005–2009)
  • UB Health Sciences Institutional Review board; Member (2005–2007)
  • UB Interdisciplinary Research Development Fund Review Panel; Member (2005–2006)
  • University at Buffalo-Interdisciplinary Research Development Fund Review Panel; Member (2005–2006)
  • Department of Electrical Engineering Faculty Search Committee; Member (2005)
  • NIH, Ad hoc member, Clinical & Integrative Cardiovascular Sciences Study Section Ad hoc member, Clinical & Integrative Cardiovascular Sciences Study Section; Ad Hoc Reviewer (2004–2005)
  • School of Medicine and Biomedical Sciences Faculty Council; Member (2003–2005)
  • AHA-Member, National Peer Review Committee; Committee Member (2002–2004)
  • University at Buffalo-Cardiovascular Diseases Fellowship Selection Committee; Member (2002–present)
  • Cardiovascular Diseases Fellowship Selection Committee; Member (2002–present)
  • Department of Medicine Mentoring and Evaluation Committee; Member (2000–2001)
  • School of Medicine and Biomedical Sciences Medical Student Research Forum; Co-Chair (2000–present)
  • AHA-Member, New York State Research Committee; Committee Member (1999–2002)
  • Member, Department of Medicine Executive Council; Member (1999–2001)
  • NIH, Ad hoc member, Small Business: Hematology Study Section; Ad Hoc Reviewer (1999)
  • AHA-Member, Peer Review Committee, Northeast Region; Committee Member (1997–2001)

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Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, New York 14203
Phone: 716-829-2663
Fax: 716-854-1840
jaf7@buffalo.edu
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This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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