Shirley S. Chang MD
Shirley S. Chang
MD
Assistant Professor of Medicine
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Nephrology; Renal Transplantation
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDEducation and Training:
- Certificate, Graduate Certificate in Innovation and Implementation Science, University at Indiana (2019)
- Fellowship, Transplant Nephrology, University at Buffalo (2011)
- Fellowship, Transplant Nephrology Fellowship, University at Buffalo (2011)
- Fellowship, Nephrology Fellowship, Internal Medicine/Pediatrics Combined, University of Minnesota (2004)
- Residency, Internal Medicine/ Pediatrics Combined Residency, University of Minnesota (1998)
- MD, MD, University of Pittsburgh, School of Medicine (1994)
- BS, Zoology, University of Maryland (1990)
- BS, Chemistry with honors, University of Maryland (1988)
Employment:
- Transplant Nephrology Fellowship Director, Internal Medicine, University at Buffalo (2016-present)
- Assistant Clinical Professor, Department of Biomedical Informatics, University at Buffalo (2020-present)
- Assistant Professor, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2015-present)
- Assistant Professor, University of Vermont (2012–2015)
- Assistant Professor, State University of New York, Brooklyn (2005–2010)
Awards and Honors:
- American College of Physician, Fellow (2015)
- Travel Award to Update in Patient-Centered Outcome in Research In Kidney Diseases (2012)
- Travel Award to Pragmatic Trials (2011)
- Travel Award to Fellows Symposium on Transplantation (2011)
- American Society of Nephrology, Fellow (2010)
- Phi Lambda Upsilon (1992)
- Phi Beta Kappa, Golden Key (1991)
- Alpha Lambda Delta, Phi Eta Sigma, Phi Mu Epsilon, Phi Sigma (1990)
- Robert Battista Award for Undergraduate Organic Research (1988)
- Top Nephrologist
Grants and Sponsored Research:
- September 2018–August 2022
Utilization of Renin Angiotensin Aldosterone System Inhibitors in Patients with Heart Failure and/or Diabetic Nephropathy
NHLBI 5K12HL138052-2
Role: Principal Investigator - April 2020–August 2021
Looking for Answers to the COVID-19 Pandemic: Turning the tide on COVID-19 by understanding nutritional factors and using medication repurposing
Role: Co-Investigator - May 2019–August 2021
Age and Race Influences on Immunosuppression After Renal Transplant
NIH
Role: Contributor - February 2019–August 2021
Evaluatio of Patients Outcomes from the Kidney Allograft Outcome Allosure Registry
Role: Contributor - February 2018–August 2021
Observation Study to Analyze Wuality of Care for Chronic Kidney Disease Using Data from 1.3 million Patients from the Instutue for Healthcare Informatics IHI at University of Buffalo
Role: Principal Investigator - November 2017–August 2021
Enhanced Recovery after Surgery (ERAS): New Paradigm for Organ Transplantation
Role: Contributor - May 2017–February 2021
A phrase 2a, Randomized, Open-label, Active Control, Multi-Center Study to Assess the Efficacy and Safety of Bleselumb in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de novo Kidney Transplant Recipients
Astella
Role: Principal Investigator - May 2017–January 2020
Evaluation of the Benefits and Risks in Maintenance Renal Transplant Recipients Following Conversation to Nulojix(belatacept)-based Immunosuppression
Role: Principal Investigator - May 2016–March 2019
Evaluation of Acute Rejection Rate in de novo Renal Transplant Recipients Following Thymoglobulin Induction, CNI-free, Nulojix (belatacept)-based Immunosuppression
Role: Co-Investigator - January 2003–January 2004
'Effect of Glycated Albumin on Gene Expression in Diabetic Nephropathy
Viking Children's Fund Grant in Aid
Role: Co-Principal Investigator - January 2003–January 2004
'Study of Proximal Epithelial Tubular Cells Gene Expression in Diabetes by Microarray'
Viking Children's Fund Grant-in-aid
Role: Co-Principal Investigator
Journal Articles:
- Kathleen Tornatore, Calvin Meaney, Kristopher Attworrd, Daniel Brazeau, Gregory Wilding, Joseph Consiglio, Aijaz Gundroo, Shirley Chang, Vanessa Gray, Louise Cooper, Rocco Venuto. (2022) Race and sex associations with tacrolimus pharmacokinetics in stable kidney transplant recipients. Pharmacotherapy (Feb)
- Brazeau DA, Attwood K, Meaney CJ, Wilding GE, Consiglio JD, Chang SS, Gundroo A, Venuto RC, Cooper L, Tornatore KM. (2020) Beyond Single Nucleotide Polymorphisms: CYP3A5∗3∗6∗7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients. Front Genet (Aug), 11: 889-889.
- Zachariah MS, Dwivedi AK, Yip CS, Chang SS, Gundroo A, Venuto RC, Tomaszewski J, Patel SK, Sharma R. (2018) Utility of Serial Protocol Biopsies Performed After 1 Year in Predicting Long-Term Kidney Allograft Function According to Histologic Phenotype. Experimental and Clinical Transplantion (Aug), 16(4): 391-400.
- Venuto RC, Meaney CJ, Chang S, Leca N, Consiglio JD, Wilding GE, Brazeau D, Gundroo A, Nainani N, Morse SE, Cooper LM, Tornatore KM. (2015) Association of Extrarenal Adverse Effects of Posttransplant Immunosuppression With Sex and ABCB1 Haplotypes. Medicine (Baltimore) (Sep), 94(37): 1315-1315.
- Tornatore KM, Meaney CJ, Wilding GE, Chang SS, Gundroo A, Cooper LM, Gray V, Shin K, Fetterly GJ, Prey J, Clark K, Venuto RC. (2015) Influence of Sex and Race on Mycophenolic Acid Pharmacokinetics in Stable African American and Caucasian Renal Transplant Recipients. Clinical Pharmacokinet (Apr), 54(4): 423-434.
- Chang SS. (2008) Albuminuria and Diabetic Nephropathy. Pediatr Endocrinol Rev (Aug), 5(4): 974-979.
- Chang S, Caramori ML, Moriya R, Mauer M. (2008) Having One Kidney does not Accelerate the Rate of Development of Diabetic Nephropathy in Type 1 Diabetic Patients. Diabetes (Jun), 57(6): 1707-1711.
- Shrama J, Mongia A, Schoenaman M,Chang SS, D'Amgelo A, Rao M. (2008) Nephrogenic Fibrosing Dermatopathy, Cardiac Calcification and Pulmonology Hypertension in An Adolescent on Chronic Hemodialysis. Indian J Nephrol (Apr), 18(2): 70-73.
- Chang SS, Noghrey B., Schoeneman M. (2005) Pediatric Rounds: Severe Hypertension in an Adolescent Girl. Hosp Physician (Sep), 41(9): 27-32.
Abstracts:
- Tornatore KM, Meaney CJ, Consiglio JD, Wilding G, Chang SS, Venuto RC. (2015) Sex And Race Influences on Tacrolimus Pharmacokinetics in Renal Transplant Recipients. J Am Soc Nephrol, (Nov) 748A-748A
- K Tornatore, K Attwood, S Chang, A Gundroo, B Murry. (2022) Tacrolimus And Mycophenolic Acid Therapeutic Exposure Targets in Black And White Kidney Transplant Recipients. American Transplant Congress 2022. Boston, Massachusetts (Jun) Poster
- Kathleen Tornator, Aijaz Gundroo, Shirley Chang, Mahfuz Yonis, Kris Attwood, Brian Murry. (2021) Immunoreactivity of CD3+CD4+ in Stable Young, Middle Age and Elderly Kidney Transplants receiving Maintenance Tacrolimus and Mycophenolic Acid Immunosuppression. American Society of Nephrology, Kidney Week 2021. (Nov) Poster
- (2021) ABCC2 Haplotypes Associations to Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients. American Transplant Congress 2021 Rapid Fire Oral Abstract 154. (Jun), (5139) Oral
- Chang SS, Yip C, Patel S, Gundroo A, Zachariah, M. (2017) The Natural History of De Novo Donor Spedific Antibody: Results from Systemic Monitoring of DSA at ECMC. ASN Kidney Week, (Jan)
- Chang SS, Zachariah M, Mallawaarachchi I, Yip C, Shanahan T, Gundroo A, Swivedi A, Patel S,. (2017) Outcome of Systemic Monitoring DSA and Protocol Management to Optimize Renal Allograft Outcome in a Single Transplant Center. ATC, (Jan)
- Chang SS, Zachariah M., Yip C., Mallawaarachchi I., Dweivedi A., Patel S., Gundroo A., Tomaszewski J., Lu L. (2017) Correlation of Donor Clinical and Histopathological Characteristics with Graft Function in Kidney Transplant Recipients. ATC, (Jan)
- Tornatore KM, Meaney CJ, Wilding GE, Chang SS, Gundroo A, Cooper LM, Gray V, Shin KN, Fetterly GJ, Prey JJ, Clark K, Venuto RC. (2016) Influence Of Sex And Race On Mycophenolic Acid Pharmacokinetics In Stable African American And Caucasian Renal Transplant Recipients. Clinical Pharmacology & Therapeutics, (Feb) S28-S28
- Chang SS, Zachariah, M. (2016) Utility of Pre-Implantation Deceased Donor Kidney Biopsy and Scoring System in Predicting Early Graft Outcome based on Kidney Donor Profile Index and Estimated post-transplant Survival. ASN Kidney Week 2016, (Jan)
Professional Memberships:
- The Transplant Society (2019–present)
- American Society of Apheresis (2014–present)
- American Society of Transplantation (2010–present)
- International Society of Nephrology (1999–present)
- National Kidney Foundation (1999–present)
- American College of Physicians (1994–present)
- American Medical Association (1990–present)
Service Activities:
- American Society of Nephrology; Member of Self-Assessment Program Review Panel for 2022-2026 (2022)
- UNOS Region 9; Alternate Delegate (2013–present)
- American Society of Transplantation Infectious Disease Community of Practice; Member (2013–present)
- American Society of Transplantation Live Donor Community of Practice; Member (2013–present)
- American Society of Transplantation Trainee and Young Faculty Community of Practice; Member (2013–present)
- American Society of Transplantation Women's Health Community of Practice; Member (2013–present)
- Women in Nephrology; Member (2012–present)