Vijay S. Iyer MD, PhD
Vijay S. Iyer
MD, PhD
Chief, Cardiovascular Medicine; Associate Professor of Medicine
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cardiology; Interventional Cardiology
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDProfessional Summary:
I am an interventional cardiologist specializing in structural heart interventions. My clinical practice includes general cardiology, interventional cardiology and complex valvular heart diseases. I see patients at the UBMD cardiology offices--and at Buffalo General Medical Center (BGMC), where I direct the complex valve clinic. I also direct structural heart interventions at the Gates Vascular Institute (GVI) and BGMC, and in that capacity I perform transcatheter aortic valve replacements, mitral clip procedures, left atrial appendage occlusion, atrial and ventricular septal defect closure and percutaneous paravalvular leak closures. I also care for patients by performing routine diagnostic coronary angiograms and percutaneous coronary interventions (PCI)/angioplasty.
I believe that in this era of technologically advanced, modern medicine it is the physician’s responsibility to educate patients in a straightforward and open manner about the different treatment modalities. I spend time with my patients to ensure that they are comfortable with the treatment options they choose and that they have a clear understanding of the alternatives, benefits and risks.
My research interests are in new devices for aortic and mitral valve replacement, novel therapeutics in the form of stem cells and newer therapies for acute coronary syndromes. I also collaborate with the Toshiba Stroke Research Center to develop advanced imaging modalities in the cardiac catheterization laboratory. I am investigating the use of robotic PCI to improve precision in stent placement and reduce radiation dosage in the catheterization laboratory, and I serve as the local principal investigator for a number of multicenter clinical trials in these areas. For example, I am: evaluating the LOTUS transcatheter valve to CoreValve in high-risk patients (Reprise III, Boston Scientific); investigating the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic aortic stenosis (AS) at intermediate surgical risk by randomizing patients to either surgical aortic valve replacement (SAVR) or TAVI (SURTAVI, Medtronic); and determining the efficacy of cardiac stem cells in patients with recent myocardial infarction and ischemic cardiomyopathy (ALLSTAR, Capricor.
I train residents and cardiology fellows through didactic and bedside teaching, and I mentor their research projects. I also oversee cardiology fellows in outpatient settings. Additionally, I collaborate with the departments of Anesthesiology and Pediatrics and the Division of Pulmonary, Critical Care and Sleep Medicine to train their residents and fellows.
Education and Training:
- Fellowship, University of Minnesota (2009)
- Fellowship, University at Buffalo (2006)
- Division of Cardiology, University at Buffalo (2003)
- Residency, Internal Medicine, University at Buffalo (2002)
- PhD, Pharmacology, Drexel University, Philadelphia, PA (2001)
- MD, Internal Medicine, Grant Medical College, Maharashtra University Of Health Sciences (1995)
Employment:
- Chief, Department of Medicine-Cardiology, Cardiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2019-present)
- Director, Structural Heart Interventions, Kaleida Health (2016-present)
- Associate Professor of Medicine, University at Buffalo (2014-present)
- Staff Cardiologist, VA Medical Center (2006-present)
- Research Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2006–2014)
- Medical Director of Cardiology, Buffalo General Medical Center (2011–2013)
- Attending Cardiologist, University at Buffalo (2006–2008)
Awards and Honors:
- American Heart Association 2017-2018 Gold Standard Board Awards, bronze recognition for executing best practices. (2018)
- Northwestern University Young Investigators Forum Finalist (2006)
- Bristol Myers Squib-ACC Travel Award (2004)
- Young Investigator Award, NYS ACC (2003)
- American Heart Association Postdoctoral Fellowship (2002)
- Joel Gernsheimer Award (2001)
- Best Research Poster Award MCP Hahnemann School of Medicine Annual Scientific Meeting (1999)
- Awarded Distinction in Preventive and Social Medicine, University of Bombay (1994)
- Awarded Distinction in Pharmacology and Therapeutics, University of Bombay (1992)
- Awarded Distinction in Human Physiology, University of Bombay (1990)
Research Expertise:
- Cardiovascular stem cell therapy
- Percutaneous aortic/mitral valve replacement
Grants and Sponsored Research:
- January 2017–January 2019
Validation of a CT based FFR software using the 640 Slices Aquilion Scanner
Jacobs Institute
Role: Co-Investigator
$81,115
Journal Articles:
- Kumamaru, K, Angel, ER, Sommer, KN, Iyer VS, Wilson MF, Agrawal, N, Bhradwaj, A, Kattel, SB, Kondziela, S, Pogorzelski, K, Ramanan, T, Sawant, A, Manion, C, Suplicki, MM, Waheed, S, Fujimoto, S, Sharma U, Ionita CN, Rybicki, F. (2019) Comprehensive analysis of inter- and intra-operator variability in measurement of CT-derived fractional flow reserve based on structural and fluid analysis. Cardiothoracic Imaging (Dec).
- Kumamaru, Kanako K., Angel, Erin, Sommers, Kelsey, Iyer VS, Wilson MF, Agrawal, Nikhil, Bhardwaj, Aishwarya, Kattel, Sharma, Kondziela, Sandra, Malhotra, Saurabh, Manion, Christopher, Pogorzelski, Katherine, Ramanan, Tharmathai, Sawant, Abhishek, Suplicki, Mary, Waheed, Sameer, Fujimoto, Shinichiro, Sharma U, Rybicki, Frank, Ionita, Ciprian. (2019) Inter- and Intraoperator Variability in Measurement of On-Site CT-derived Fractional Flow Reserve Based on Structural and Fluid Analysis: A Comprehensive Analysis. Radiology: Cardiothoracic Imaging (Aug).
- Sommer S, Angel E, Iyer VS, Wilson MF, Rybicki FJ, Mitsouras D, Molloj S, Ionita CN, Ionita CN. (2019) Initial Evaluation of three-Dimensionally Printed Patient-Specific Coronary Phantoms for CT-FFR Software VAlidation. J Med Imaging (Apr), 6(2).
- Lazkani M, Sawant AC, Taase A, Khan S, Fang K, Iyer VS, Pershad A. (2019) Left Atrial Hemodynamics and Left Ventricular Remodeling - Predictors of Outcomes after Transcatheter Mitral Valve Repair with MitraClip Device. Catheter Cardiovasc Interv (Jan), 93(1): 128-133.
- Ahmed, M, Yatsynovich, Y, Ramanan, T, Colern, G, Hansen, R, Cimato TR, Graham S, Page BJ, Iyer VS. (2019) Aortic Paravalvular Leak Repair. J Am Coll Cardiol (Jan), 3: 42-45.
- Kapur NK, Alkhouli MA, DeMartini TJ, Faraz H, George ZH, Goodwin MJ, Hernandez-Montfort JA, Iyer VS, Josephy N, Kalra S, Kaki A, Karas RH, Kimmelstiel CD, Koenig GC, Lau E, Lotun K, Madder RD, Mannino SF, Meraj PM, Moreland JA, Moses JW, Kim RL, Schreiber TL, Udelson JE, Witzke C, Wohns DHW, O'Neill WW. (2019) Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment-Elevation Myocardial Infarction. Circulation (Jan), 139(3): 337-346.
- Khalil C, Pham M, Sawant AC, Sinibaldi E, Bhardwaji A, Ramanan T, Qureshi R, Khan S, Ibrahim A, Gowada SN, Pomakov A, Sadawarte P, Lahoti A, Hansen R, Baldo S, Colern G, Pershad A, Iyer VS. (2018) Neutrophil-to-lymphocyte ratio predicts heart failure readmissions and outcomes in patients undergoing transcatheter aortic valve replacement. Indian Heart J (Dec), 70(3): S313-S318.
- Weil BR, Suzuki G, Young, R, Iyer VS, Canty J. (2018) Cardiac Troponin I Release and Reversible Left Ventricular Dysfunction Following Transient Pressure Overload: Stretch-Induced Myocardial Stunning. J Am Coll Cardiology (Jun), 71(25): 2906-2916.
- Bhardwaj A, Ramanan T,Sawant A, Sinibaldi E, Pham M, Khan S, Qureshi R, Agrawal N, Khalil C, Hansen R, Baldo S, Colern G, Corbelli J, Pershad A, Beck H, Iyer V. (2018) Quality of life outcomes in transcatheter aortic valve replacement patients requiring pacemaker implantation. Journal of Arrythmia (Jun), 1(5-6): 1-9.
- Feldman TE, Reardon MJ, Rajagopal V, Makkar RR, Bajwa TK, Kleiman NS, Linke A, Kereiakes DJ, Waksman R, Thourani VH, Stoler RC, Mishkel GJ, Rizik DG, Iyer VS, Gleason TG, Tchétché D, Rovin JD, Buchbinder M, Meredith IT, Götberg M, Bjursten H, Meduri C, Salinger MH, Allocco DJ, Dawkins KD. (2018) Effect of Mechanically Expanded vs Self-Expanding Transcatheter Aortic Valve Replacement on Mortality and Major Adverse Clinical Events in High-Risk Patients With Aortic Stenosis: The REPRISE III Randomized Clinical Trial. JAMA (Jan), 319(1): 27-37.
- Guerrero, M, Wang, DD, Himbert D, Pursnani A, Kaddissi G, Iyer VS, Salinger M, Chakravarty T, Greenbaum A, Makkar R, Vahanian A, Feldman T, O'Neill W. (2017) Short-term results of alcohol septal ablation as a bail-out strategy to treat severe left ventricular outflow tract obstruction after transcatheter mitral valve replacement in patients with severe mitral annular calcification. Catheter Cardiovasc Interv (Dec), 90(7): 1220-1226.
- Aishwarya Bhardwaj, Tharmathai Ramanan, Charl Khalil, Michael Pham, Everett Sinibaldi, Rosemary Hansen, Shannon Baldo, Gerald Colern, Abhishek Sawant, John Corbelli, Stanley Fernandez, Vijay Iyer. (2017) Valvuloarterial Impedance Predicts hart Failure Readmissions in Patients Undergoing Transcatheter Aortic Valve Replacement. Structural Heart Journal (Aug)1-8.
- Weil BR, Konecny F, Suzuki G, Iyer V, Canty JM. (2016) Comparative Hemodynamic Effects of Contemporary Percutaneous Mechanical Circulatory Support Devices in a Porcine Model of Acute Myocardial Infarction. JACC Cardiovasc Interv (Nov), 9(22): 2292-2303.
- Koudoumas D, Iyer VS, Curl RG. (2015) Simultaneous Percutaneous Transcatheter Aortic Valve Replacement and Endovascular Abdominal Aortic Aneurysm Repair in a High Risk Patient with Hostile Aortic Neck; case report. J Cardiothoracic Surgery (Dec), 10(184).
- Bennett NM, Iyer VS, Arndt TL, Garberich RF, Traverse JH, Johnson RK, Poulose AK, Lips A, Morgan JM, Henry TD. (2014) Ranolazine Refractory Angina Registry - 1 year results. Crit Pathw Cardiol (Sep), 3: 96-98.
- Acharjee S, Dewanwala, A, Piccone AL, Iyer VS. (2012) Anticoagulation for atrial fibrillation after coronary artery bypass grafting: how soon is soon enough?. J Cardiovasc Surg (Jan), 53(4): 553-555.
- Suzuki G, Iyer V, Lee TC, Canty, JM Jr. (2011) Autologous mesenchymal stem cells mobilize cKit positive and CD133 positive bone marrow progenitor cells and improve regional function in hibernating myocardium. Circulation Research (Oct), 109(9): 1044-1054.
- Suzuki G, Iyer V, Lee TC, Canty, JM Jr. (2011) Autologous mesenchymal stem cells mobilize cKit positive and CD133 positive bone marrow progenitor cells and improve regional function in hibernating myocardium. Circulation Research (Oct), 109(9): 1044-1054.
- Suzuki G, Iyer V, Cimato T, Canty JM Jr. (2009) Pravastatin improves function in hibernating myocardium by mobilizing CD133 and cKit bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle. Circulation Research (Jan), 104: 255-264.
- Suzuki G, Iyer V, Cimato T, Canty JM. (2009) Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle. Circ Res (Jan), 104(2): 255-264.
- Page B, Young RF, Iyer VS, Suzuki G, Lis M, Blumenthal KM and Canty JM Jr. (2008) Persistent Regional Downregulations in Mitrochondrial Enzymes and Upregulation of Stress Proteins in Swine with Chronic Hibernating Myocardium. Circulation Research (Jan), 102(1): 103-112.
- Leiker M, G Suzuki, VS Iyer, JM Canty Jr., and TC Lee. (2008) Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells. Cell Transplantation (Jan)911-922.
- Canty JM, Iyer VS. (2007) Hydrogen peroxide and metabolic coronary flow regulation. J Am Coll Cardiol (Sep), 50(13): 1279-1281.
- Canty JM Jr and VS Iyer. (2007) Hydrogen peroxide and metabolic coronary flow regulation. J Am College of Cardiology (Jan), 50: 1279-1281.
- Iyer VS, Canty JM. (2005) Regional desensitization of beta-adrenergic receptor signaling in swine with chronic hibernating myocardium. Circ Res (Oct), 97(8): 789-795.
- Iyer VS and JM Canty Jr. (2005) Regional desensitization of beta-adrenergic receptor signaling in swine with chronic hibernating myocardiun. Circulation Research (Jan), 97: 789-795.
Abstracts:
- Shepard LM, Sommer K, Iyer VS, Wilson MF, Rybicki FJ, Mitsouras D, Angel E, Said Z, Rudin S, Ionita CN. (2017) 3D printed patient-specific coronary models for testing CT-derived FFR. RSNA Scientific Program, (Nov)
- Izzo RL, O‘Hara RP, Iyer V, Hansen R, Meess KM, Nagesh SVS, Rudin S, Siddiqui AH, Springer M, Ionita CN. (2016) 3D Printed Cardiac Phantom for Procedural Planning of a Transcatheter Native Mitral Valve Replacement. Proc SPIE Int Soc Opt Eng, (Apr) 97890
- Rajagopalan B, Malhotra S, Iyer V, Morris W and Zlotnick D. (2015) Too much calcium, too little gradient: An unusual case of low gradient aortic stenosis. J Am Coll Cardiol, (Jan) A662
- Suzuki G, VS Iyer, AQ Shabbir, D Zisa, BA Palka, T Cimato, TC Lee and JM Canty Jr. (2009) Pravastatin followed by intracoronary fibroblast growth factor (FGF-5) synergistically amplifies endogenous cardiac repair in swine with hibernating myocardium. J. Am College of Cardiology, (Jan) A186
- Suzuki G, V Iyer, T-C Lee and JM Canty Jr. (2007) Intracoronary mesenchymal stem cells (MSCs) increases the myocardial localization of CD133 hematopoietic stem cells (HSCs) in swine with hibernating myocardium. Circulation, (Jan) 133
- Iyer VS, G Suzuki, JM Hardy, BM Heavey, JA Fallavollita and JM Canty Jr. (2004) Time-dependent upregulation of extracellular matrix proteins in chronic hibernating myocardium: Lack of progressive degeneration. J. Am College of Cardiology, (Jan) 294A-295A
- Iyer VS, RF Young, M Lis, N Nowak, K Blumenthal and JM Canty Jr. (2003) Microarray and proteomic analysis reveals a regional reduction in the expression of mitochondrial metabolic enzymes in swine with chronic hibernating myocardium. Circulation, (Jan) 275
Professional Memberships:
- Member, SCAI Advocacy Council; Member, SCAI Advocacy Council (2018–present)
- President, Buffalo Niagara American Heart Association; President, Buffalo Niagara American Heart Association (2017–present)
- Western New York Vascular Society; Member (2012–present)
- Councilor, American College of Cardiology, NY Chapter; Councilor, American College of Cardiology, NY Chapter (2011–2016)
- Fellow, American College of Cardiology (2006–present)
- American Heart Association (2005–present)
- Fellow, Society for Coronary Angiography and Interventions (2000–present)
- Maharashtra Medical Council of India; Member (1989–present)
- American Society of Echocardiography
Presentations:
- "Cardiogenic Shock Panel, Shock Protocol" Leadership Alliance for Cardiovascular Care; Leadership Alliance for Cardiovascular Care; Conference Attendees (2018)
- "Current Practices in TAVR" Fellows 101 Interventional Cardiology & Structural Heart; Boston, MA; Fellows 101 Interventional Cardiology & Structural Heart; Fellows (2018)
- "Radial Access ST Elevation Myocardial Infarction; Toolbox for Success" CRT-2017; CRT-2017; Conference Attendees (2017)
- "Contrast Induced Neuropathy" C3, Advanced Endovascular and Coronary Intervention Global Summit; C3; Fellows' Program (2017)
- "Different Unloading Profiles in a Porcine Modle of Acute Myocardia Ischemia" The Impella CP and Tandem Heart Percutaneous Circulatory Support Devices Show; TCT 2014; Conference Attendees (2014)
- "Acute RCA Occlusion after Valve in Valve Implantation" TCT 2013; TVT 2013; Conference Attendees (2013)
- "Dose Reduction Strategies in the Cardiac Catheterization Laboratory" ACC 2012; ACC; Conference Attendees (2012)
- "Pravastatin Dose Dependently Increases CD117, CD133, VEGFR2" Northwestern Young Investigators Forum; Northwestern Young Investigators Forum; Conference Attendees (2003)
Service Activities:
- Leadership Alliance for Cardiovascular Care Board; Member (2018–present)
- Ad Hoc Committee on Promotions to Clinical Ranks, SUNY Buffalo, Jacobs School of Medicine and Biomedical Sciences.; Member (2016–2019)
- Gates Vascular Institute, President Physician Leadership Board; Chair (2016–present)
- Kaleida Health Heart Administration Team Committee; Member (2016–present)
- Gates Vascular Institute Physician Leadership Board; Member (2014–present)
- Director, Cardiac LLC Gates Vascular Institute/BGMC; Director (2013–2014)
- Gates Vascular Institute Operations Committee; Member (2013–present)
- Buffalo General Hospital Strategic Group Advisory Board; Member (2013–present)
- Buffalo General Hospital Physician Advisory Council; Advisor (2012–present)
- Gates Vascular Institute Research Advisory Committee; Advisor (2012–present)
- Faculty Senate; Member (2012–present)
- Gates Vascular Physician Leadership Committee; Member (2012–present)
- Cardiac Catheterization Quality Assurance; Member (2012–present)
- Board of Directors; Academic Medical Services, UB; Member (2012–present)
- Cardiac Catheterization Laboratory Peer Review; Member (2010–present)
- Reviewer - "Heart" Reviewer - "Heart"; Reviewer
- Reviewer - AJP Reviewer - AJP; Reviewer
- Reviewer - American Journal of Cardiology Reviewer - American Journal of Cardiology; Reviewer
- Reviewer - Cardiovascular Revascularization Medicine Reviewer - Cardiovascular Revascularization Medicine; Reviewer
- Reviewer - Circulation Research Reviewer - Circulation Research; Reviewer
- Reviewer - Circulation-Japanese Circulation Society Reviewer-Circulation-Japanese Circulation Society; Reviewer
- Reviewer - Journal of the American College of Cardiology Reviewer - Journal of the American College of Cardiology; Reviewer
- Reviewer - New England Journal of Medicine (ad hoc) Reviewer - New England Journal of Medicine (ad hoc); Reviewer