Xiaoyan Wu MD, PhD

Xiaoyan Wu

Xiaoyan Wu
MD, PhD

Clinical Associate Professor

Department of Pediatrics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Hematology; Membrane Transport (Ion Transport); Models - cell and animal; Molecular and Cellular Biology; Nephrology; Pediatric Nephrology; Pediatrics; Urology; Vascular Medicine; Whole Genome Sequencing

Contact Information
UBMD Pediatrics
Division of Nephrology
1001 Main Street
Buffalo, New York 14203
Phone: (716) 323-0140
Fax: (716) 323-0292
xwu42@buffalo.edu


Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD


Professional Summary:

My research concentrates on understanding mechanisms that underlie hypertension, kidney disease, and kidney development. In the laboratory, I have developed methods to isolate renal endothelial cells from mice. Using the primary culture cells, I have studied roles of endothelium in acute kidney injury and intracellular calcium signaling. The animal models what I have used include not limited to the bullfrog, mice, rats, rabbits, and monkeys.
My current research proposal at UB focuses on detecting the gene(s) responsible for congenital anomalies of the kidney and urinary tract (CAKUT). If the mutation of gene(s) is identified, my next step is to apply gene editing technique, attempting to repair the defect on the laboratory bench. The ultimate goal is to use gene therapy effectively to delay disease progression in children with CAKUT and improve the outcomes.
My clinical focus has been the care and management of patients with CAKUT, complex glomerular and autoimmune disease, and end stage of renal disease (ESRD) who undergo dialysis or kidney transplant. I serve as attending physician on the transplant clinic for UBMD pediatrics. I am also an attending physician on the inpatient renal service at Oishei Children Hospital, Buffalo NY.
As an educator, I am committed to the career development of the students, trainees and faculty working with me in the laboratory, in medical school class rooms (live vs virtual), in clinical areas and hospital patients’ bedsides. I introduced them to give presentation at national conferences, and published case reports on peer-reviewed journals. Over the course of my career, I have mentored medical students, graduate students, residents and follows. Some have gone on to become academic physicians. Through my commitment, I help ensure continued quality improvement in nephrology training, in multiple institutions including Jacobs School of Medicine and Biomedical Sciences, Buffalo NY.

Education and Training:

  • Fellowship, Pediatric Nephrology, Baylor College of Medicine (2017)
  • Residency, Pediatrics, Richmond University Medical Center (2014)
  • Internship, Pediatrics, Richmond University Medical Center (2012)
  • Fellowship, Medicine, University of Toronto (1997)
  • PhD, Physiology, University of Toronto (1996)
  • MS, Physiology, University of Toronto (1991)
  • MD, Medicine, Tianjin Medical University (1982)

Employment:

  • Attending Physician, Nephrology, Oishei Children's Hospital (2017-present)
  • Clinical Associate Professor, Pediatrics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2017-present)
  • Assistant Professor, Pediatric Nephrology, Baylor College of Medicine (2017)
  • Research Assistant Professor, University of Chicago Pritzker School of Medicine (2006–2011)
  • Research Associate, University of Chicago Pritzker School of Medicine (1997–2006)
  • Visiting Scholar, University of Louisville School of Medicine (1986–1989)

Awards and Honors:

  • Top Doctor by Buffalo Spree’s list Western New York’s, NY (2022)
  • Top Doctor by Buffalo Spree’s list Western New York’s, NY (2021)
  • Top Doctor by Buffalo Spree’s list Western New York’s, NY (2020)
  • 44th Pediatric Nephrology Seminar/Renal Pathology/CRRT Course: Partial Travel Grant (2017)
  • American Society of Nephrology: Karen L. Campbell Travel Grant (2016)
  • Richmond University Medical Center: Mario J. Merlino Award (2014)
  • Academy of Medicine of Richmond: 3rd Prize (2013)
  • Buffalo Spree Magazine: Top Doctors in Western New York (2020-2021)
  • University of Louisville: Nephrology Fellowship (07/1986-09/1989)
  • University of Toronto: Nephrology Postdoctoral Fellowship (09/1996-08/1997)
  • University of Toronto: Open Physiology Fellowship (09/1989-09/1996)

Research Expertise:

  • Calcium signaling
  • Electrolyte: Epithelial transport
  • Gene profiles of patients with CAKUT
  • Hypertension: Blood pressure measurements from animals to human being
  • kidney transplant in pediatrics
  • Primary culture endothelial cells from glomeruli in mice: animal model of acute kidney injury
  • renal replacement therapy in pediatric patients with kidney injury

Journal Articles:

See all (19 more)

Abstracts:

  • Mia Pivirotto, Beverly Schaefer, Mary O’Shea, Wayne Waz, Xiaoyan Wu. (2021) Management of Pediatric post-renal transplant erythrocytosis with enalapril: A case report. ESPR, (Mar)
  • Andrew Toenniessen, Hula Al-Rashidy, Xiaoyan Wu. (2020) Prevalence of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) in the greater Buffalo region: A retrospective study. Eastern Society for Pediatric Research (ESPR), (Mar)
  • Shauna Tarsi, Lin Liu, Wayne R. Waz, Xiaoyan Wu. (2020) Complete renal recovery in patient with anuria AKI of 72 hours with Hypertensive Encephalopathy: A case report of APSGN. Eastern Society for Pediatric Research (ESPR), (Mar)
  • Villereal ML, Wu X, Zagranichnaya TK, Gurda GT. (2005) A TRPC1/TRPC3-Mediated Increase in Store-Operated Calcium Entry is Required for Differentiation of H19-7 Hippocampal Cells. FASEB J, (Mar) A677-A677
  • Villereal ML, Zagranichnaya TK, Wu X. (2003) Role of Store-Operated Calcium Channels in Regulating Gene Expression. FASEB J, (Mar) A45-A45
  • Wu X, Babnigg G, Villereal ML. (2000) Store-Operated Calcium Entry in HEK-293 Cells: Are Human Transient Receptor Potential (HTRP1, HTRP3 and HTRP4) Proteins Functionally Important?. FASEB J, (Mar) A577-A577
  • Melo LG, Vieth R, Milojevic S, Sonnenberg H, Wu X. (2000) Regulation of Vitamin D in Dahl Rats on High Salt-Low Potassium Diet: Genetic and Neural Influences. FASEB J, (Mar) A95-A95
  • Wu X, Scholey JW, Sonnenberg H, Melo LG. (2000) Renal Vascular Morphology and Hemodynamics in Dahl Rats on High Salt-Low Potassium Diet: Neural and Genetic Influences. FASEB J, (Mar) A95-A95
  • Wu X, Ackermann U, Sonnenberg H. (1991) The Role of Renal Perfusion Pressure in Control of Urinary Sodium Excretion. FASEB J, (Mar) A1040-A1040
  • Carrasquer G, Wu X, Schwartz M, Rehm WS. (1990) Voltage Clamp Studies on Frog Gastric Mucosa. FASEB J, (Feb) A446-A446
  • Wu X, Carrasquer G, Rehm WS, Schwartz M, Dinno MA. (1989) Microelectrode Studies of Changes in Tear K+ in Presence of Amphotericin B in Frog Cornea. FASEB J, (Feb) A859-A859
  • Wu X, Carrasquer G, Rehm WS, Schwartz M, Dinno MA. (1988) Effects of SCN- on Electrophysiological Parameters in Cornea. FASEB J, (Mar) A1726-A1726
See all (2 more)

Professional Memberships:

  • American Academy of Pediatrics
  • American Society of Nephrology
  • American Society of Pediatric Nephrology
  • Eastern Society for Pediatric Research

Presentations:

  • "Profound proteinuria in a pediatric patient with membranous nephropathy secondary to SLE" ESPR/AFMR 1s Annual Eastern Medical Research Conference (2022)
  • "Role of dd-cfDNA in detection of subclinical rejection in pediatric kidney transplant recipients" ESPR/AFMR 1s Annual Eastern Medical Research Conference (2022)
  • "Blockade of the terminal complement cascade using Ravulizumab in a pediatric patient with aHUS: a case report and literature review" Annual Conference; Eastern Society for Pediatric Research (2021)
  • "Management of Pediatric Post-renal Transplant Erythrocytosis with Enalapril: A Case Report" Annual Conference; Eastern Society for Pediatric Research (2021)
  • "Complete Renal Recovery in Patient with a Rare Kidney Disease: A Case Report of C3GN" Annual Conference; Eastern Society for Pediatric Research; E-ESPR2020: 339 (2020)
  • "Complete Renal Recovery in Patient with Anuria AKI of 72 hours with Hypertensive Encephalopathy: A Case Report of APSGN" Annual Conference; Eastern Society for Pediatric Research; E-ESPR2020: 289 (2020)
  • "Prevalence of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) in the Greater Buffalo Region: A Retrospective Study" Annual Conference; Eastern Society for Pediatric Research; E-ESPR2020: 308 (2020)
  • "Renal Involvement and Its Treatment in Pediatric Patients with PR3 ANCA Positive Granulomatosis with Polyangiitis (GPA)" Annual Conference; Eastern Society for Pediatric Research; E-ESPR2020: 340 (2020)
  • "The Effect of Intermittent Hypoxia-Hyperoxia During Nephrogenesis vs Nephronal Maturation and Risk of Kidney Disease and Hypertension in Adult Mice" Annual Meeting; Pediatric Academic Societies; Nephrology: Hypertension (2019)
  • "Effects of Intermittent Hypoxia-Hyperoxia During Nephrogenesis versus Nephronal Maturation and the Risk of Chronic Kidney Disease and Hypertension in Adult Mice" Annual Conference; Eastern Society for Pediatric Research; Allergy/Immunology & Nephrology (2019)
  • "Role of Hypoxia-Hyperoxia on Nephrogenesis and Nephronal Maturation and Its Risk of Kidney Disease and Hypertension in Adult Mice" Annual Conference; Eastern Society for Pediatric Research (2019)
  • "The Complement System: Why Do We Care?" Pediatric Grand Rounds; University at Buffalo (2019)
  • "Chyloperitoneum in a Neonate with ESRD on Peritoneal Dialysis: A Case Report" Renal Week; American Society of Nephrology (2016)
  • "Macrophage Calcium Signaling in Inbred Hypertensive Rat Lines" Annual Meeting; American Society of Pediatric Nephrology (2016)
  • "Efficient Rounding Improves Patient Care and Decreases Resident Duty Hour Violations on CORE Rotation: A Quality Improvement Initiative" Pediatric Research and Fellow Symposium; Texas Children‘s Hospital and Baylor College of Medicine (2016)
  • "Case Report: Flavobacteremia Meningosepticum Bacteremia in a Sickle Beta Cell Patient" 23rd Annual Meeting; Academy of Medicine of Richmond (2012)
  • "Sepsis Actively Modulates Renal Expression of the Tie2-Angiopoietin System During Acute Kidney Injury" Renal Week; American Society of Nephrology (2008)
  • "TNF-Induces Caspase-Dependent Inflammation in Renal Endothelial Cells" Renal Week; American Society of Nephrology (2008)
  • "A Novel Method for the Separation and Primary Culture of Glomerular and Nonglomerular Renal Endothelial Cells" Renal Week; American Society of Nephrology (2007)
  • "An Increase in Store-Operated Channel Activity Occurs During the Differentiation of Hippocampal Neurons" Experimental Biology; Federation of American Societies for Experimental Biology (2007)
  • "Decreased Susceptibility to LPS-Induced Acute Renal Failure in Bak-Deficient Mice" Renal Week; American Society of Nephrology (2006)
  • "A New Model for the Activation of Store-Operated Channels" Experimental Biology; Federation of American Societies for Experimental Biology (2006)
  • "A TRPC1/TRPC3-Mediated Increase in Store-Operated Calcium Entry is Required for Differentiation of H19-7 Hippocampal Cells" Experimental Biology; Federation of American Societies for Experimental Biology (2005)
  • "Role of Store-Operated Calcium Channels in Regulating Gene Expression" Experimental Biology; Federation of American Societies for Experimental Biology (2003)
  • "The Role of Human Transient Receptor Potential Protein 4 (HTRP4) in the Thapsigargin-, Carbachol-, and Diacylglycerol-Stimulatedc Calcium Entry in HEK-293 Cells" Experimental Biology; Federation of American Societies for Experimental Biology (2002)
  • "Regulation of Vitamin D in Dahl Rats on High Salt-Low Potassium Diet: Genetic and Neural Influences" Experimental Biology; Federation of American Societies for Experimental Biology (2000)
  • "Renal Vascular Morphology and Hemodynamics in Dahl Rats on High Salt-Low Potassium Diet: Neural and Genetic Influences" Experimental Biology; Federation of American Societies for Experimental Biology (2000)
  • "Store-Operated Calcium Entry in HEK-293 Cells: Are Human Transient Receptor Potential (HTRP1, HTRP3 and HTRP4) Proteins Functionally Important?" Experimental Biology; Federation of American Societies for Experimental Biology (2000)
  • "The Role of Renal Perfusion Pressure in Control of Urinary Sodium Excretion" Experimental Biology; Federation of American Societies for Experimental Biology (1991)
  • "Voltage Clamp Studies on Frog Gastric Mucosa" Experimental Biology; Federation of American Societies for Experimental Biology (1990)
  • "Microelectrode Studies of Changes in Tear K+ in Presence of Amphotericin B in Frog Cornea" Experimental Biology; Federation of American Societies for Experimental Biology (1989)
  • "Effects of SCN- on Electrophysiological Parameters in Cornea" Experimental Biology; Federation of American Societies for Experimental Biology (1988)
See all (22 more)

Service Activities:

  • I have been actively involved in resident interviews. The interviews were conducted in live and virtual (COVID pandemic).; interviews of pediatric residents (2018–2021)
  • At Texas Children's Hospital & Baylor College of Medicine, I was actively involved in fellow interview and fellow selection during fall season. We secured 3 positions for renal fellow.; fellowship selection (2016–2017)
  • I reviewed the articles in the field of pediatric nephrology, SLE, lupus nephritis, and kidney injury; During my fellowship training, I was an active member of Journal reviewer for Pediatric Research (2016–2017)
  • AT the RUMC, I was a pediatric resident and a photographer . My camera captured graduation ceremony, Christmas parties. My video performance became center of presentation on graduation parties.; a photographer (2013–2014)
  • At Richmond University Medical Center (RUMC), I was a member of the planning committee for the 2012 Fashion Show. We had NICU graduates returned to hospital, along with current residents and attendings, performed a fashion show. We raised money which we used to build breast feeding unit in NICU. During the fashion show, I was the photographer, and I recorded the event. Video was distributed to people with donation.; planning committee (2012)
  • At Pritzker School of Medicine, University of Chicago, I was an active member participating and organizing Department of Medicine annual research day. These were the 3rd biggest events for Department of Medicine (next to Christmas party and graduation ceremonies) at which time invited speakers, distinguishing professors, and outstanding graduate students were presenting and exchanging ideas on science and technology.; an active member participating and organizing Department of Medicine annual research day (2006–2010)
  • At Pritzker School of Medicine, University of Chicago, I was an active member at Committee for Summer Internship. We selected medical students based on their research interests and school performance. Once enrolled, we trained the interns for basic science skills. At the end of training, most of students were able to conduct routine laboratory experiments. Significant numbers of students enrolled in MD/PhD programs across the nation, becoming academic physicians.; an active member at Committee for Summer Internship (2000–2004)
  • At Pritzker School of Medicine, University of Chicago, I was an active member participating and organizing annual Department retreat, the 3rd biggest events for the Department (next to Christmas party and graduation ceremonies) at which time invited speakers, distinguishing professors, and outstanding graduate students were presenting and exchanging ideas on science and technology.; An active member participating and organizing annual retreat (2000–2004)
  • At the University of Toronto, I was active in participating and organizing ballroom dancing parties, volleyball and tennis tournaments.; Committee of Chinese Student (1994–1996)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

UBMD Pediatrics
Division of Nephrology
1001 Main Street
Buffalo, New York 14203
Phone: (716) 323-0140
Fax: (716) 323-0292
xwu42@buffalo.edu

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD