David Dietz, PhD, investigates cellular changes by which drugs “hijack” the central nervous system’s reward circuitry, causing addiction. He studies how differences in individuals’ molecular and behavioral plasticity mediate susceptibility to drug abuse and relapse.
Margarita L. Dubocovich, PhD, works to elucidate melatonin’s mechanism of action and role in modulating circadian rhythms. Her lab develops novel molecules targeting melatonin receptors to treat depression, sleep disorders and cardiovascular disease.
Thomas Russo, MD, is internationally known for his work with strains of E. coli that cause infections outside the intestine and result in morbidity worldwide due to pneumonia, urinary tract infections and meningitis.
Noreen Williams, PhD, studies parasitic protozoans, including Trypanosoma brucei, which causes African sleeping sickness, transmitted by the tse-tse fly; and Trypanosoma cruzi, which causes Chagas’ disease, transmitted by the reduviid bug.
James R. Olson, PhD, has traveled to Egypt to work with cotton laborers exposed to pesticides. His research links genetics, an individual’s degree of exposure to pesticides and effects on health, seeking to improve workplace and environmental health worldwide.
Daniel Kosman, PhD, studies how organisms acquire and metabolize iron and copper, intrinsically toxic metals essential to cellular respiration and oxygen transport. One of his goals is to develop antifungal drugs to treat infections in humans.