An integrated academic home for UB’s outstanding clinical
research and translational science, and the hub of the Buffalo
Translational Consortium. The CTRC provides innovative research
tools, support, training, resources and coordination.
Williams, PhD, studies parasitic protozoans, including
Trypanosoma brucei, which causes African sleeping sickness,
transmitted by the tse-tse fly; and Trypanosoma cruzi, which causes
Chagas’ disease, transmitted by the reduviid bug.
Russo, MD, is internationally known for his work with strains
of E. coli that cause infections outside the intestine and result
in morbidity worldwide due to pneumonia, urinary tract infections
Rajnarayanan, PhD, studies interactomes of the human estrogen
receptor, which is expressed in 70 percent of breast cancers. His
lab seeks to design molecules to improve the effects of
tamoxifen, a drug commonly prescribed to treat breast cancer.
Laychock, PhD, is investigating the cellular mechanisms
regulating insulin secretion in pancreatic cells. Her group has
used pancreatic cells in primary culture to develop in vitro
systems that mimic aspects of Type 1 and Type 2 diabetes.
Popescu, PhD, is studying NMDA receptors in the brain, which
are involved in synaptic development, plasticity, memory and
learning, as well as in pathologies such as stroke,
neurodegeneration, chronic pain, addiction, schizophrenia and
L. Dubocovich, PhD, works to elucidate melatonin’s
mechanism of action and role in modulating circadian rhythms. Her
lab develops novel molecules targeting melatonin receptors to treat
depression, sleep disorders and cardiovascular disease.