An integrated academic home for UB’s outstanding clinical
research and translational science, and the hub of the Buffalo
Translational Consortium. The CTRC provides innovative research
tools, support, training, resources and coordination.
Williams, PhD, studies parasitic protozoans, including
Trypanosoma brucei, which causes African sleeping sickness,
transmitted by the tse-tse fly; and Trypanosoma cruzi, which causes
Chagas’ disease, transmitted by the reduviid bug.
L. Dubocovich, PhD, works to elucidate melatonin’s
mechanism of action and role in modulating circadian rhythms. Her
lab develops novel molecules targeting melatonin receptors to treat
depression, sleep disorders and cardiovascular disease.
Popescu, PhD, is studying NMDA receptors in the brain, which
are involved in synaptic development, plasticity, memory and
learning, as well as in pathologies such as stroke,
neurodegeneration, chronic pain, addiction, schizophrenia and
Dietz, PhD, investigates cellular changes by which drugs
“hijack” the central nervous system’s reward
circuitry, causing addiction. He studies how differences in
individuals’ molecular and behavioral plasticity mediate
susceptibility to drug abuse and relapse.
J. Sim, PhD, studies the molecular mechanisms controlling stem
and progenitor cell fate in the human brain. His lab seeks to
develop novel drug- and cell-based therapies for repair and
regeneration in demyelinating diseases, such as multiple