An integrated academic home for UB’s outstanding clinical
research and translational science, and the hub of the Buffalo
Translational Consortium. The CTRC provides innovative research
tools, support, training, resources and coordination.
Rajnarayanan, PhD, studies interactomes of the human estrogen
receptor, which is expressed in 70 percent of breast cancers. His
lab seeks to design molecules to improve the effects of
tamoxifen, a drug commonly prescribed to treat breast cancer.
J. Sim, PhD, studies the molecular mechanisms controlling stem
and progenitor cell fate in the human brain. His lab seeks to
develop novel drug- and cell-based therapies for repair and
regeneration in demyelinating diseases, such as multiple
R. Olson, PhD, has traveled to Egypt to work with cotton
laborers exposed to pesticides. His research links genetics, an
individual’s degree of exposure to pesticides and effects on
health, seeking to improve workplace and environmental health
Williams, PhD, studies parasitic protozoans, including
Trypanosoma brucei, which causes African sleeping sickness,
transmitted by the tse-tse fly; and Trypanosoma cruzi, which causes
Chagas’ disease, transmitted by the reduviid bug.
Kosman, PhD, studies how organisms acquire and metabolize iron
and copper, intrinsically toxic metals essential to cellular
respiration and oxygen transport. One of his goals is to develop
antifungal drugs to treat infections in humans.