An integrated academic home for UB’s outstanding clinical
research and translational science, and the hub of the Buffalo
Translational Consortium. The CTRC provides innovative research
tools, support, training, resources and coordination.
Laychock, PhD, is investigating the cellular mechanisms
regulating insulin secretion in pancreatic cells. Her group has
used pancreatic cells in primary culture to develop in vitro
systems that mimic aspects of Type 1 and Type 2 diabetes.
Williams, PhD, studies parasitic protozoans, including
Trypanosoma brucei, which causes African sleeping sickness,
transmitted by the tse-tse fly; and Trypanosoma cruzi, which causes
Chagas’ disease, transmitted by the reduviid bug.
Dietz, PhD, investigates cellular changes by which drugs
“hijack” the central nervous system’s reward
circuitry, causing addiction. He studies how differences in
individuals’ molecular and behavioral plasticity mediate
susceptibility to drug abuse and relapse.
Popescu, PhD, is studying NMDA receptors in the brain, which
are involved in synaptic development, plasticity, memory and
learning, as well as in pathologies such as stroke,
neurodegeneration, chronic pain, addiction, schizophrenia and
Rajnarayanan, PhD, studies interactomes of the human estrogen
receptor, which is expressed in 70 percent of breast cancers. His
lab seeks to design molecules to improve the effects of
tamoxifen, a drug commonly prescribed to treat breast cancer.
Russo, MD, is internationally known for his work with strains
of E. coli that cause infections outside the intestine and result
in morbidity worldwide due to pneumonia, urinary tract infections