Recent Faculty Publications

We share our research studies with physicians and scientists worldwide through publications in leading academic journals.

Singh J, Grant TD, Gulick AM. (2026) Structure of a Stand-Alone Homodimeric Nonribosomal Peptide Synthetase Condensation Domain Reveals Occlusion of the Canonical Carrier-Protein Interface. The Journal of biological chemistry (May)113208.
Dang VT, Martynowycz MW, McElheny D, Nguyen AI. (2026) ß-barrels from short macrocyclic peptides. Chemical communications (Cambridge, England) (Jan).
Barber D, Naughton F, van Hilten N, Grabe M, Paz A. (2026) A conserved salt bridge network stabilizes the hepatic organic anion transporters OATP1B1 and OATP1B3. The Journal of biological chemistry (Jan)111217. doi:10.1016/j.jbc.2026.111217
Dong L, Malkowski MG. (2025) Allosteric regulation of prostaglandin endoperoxide H2 synthases. The Journal of biological chemistry (Dec), 301(12): 110927.
MacDonald MR, Hasselbeck J, Gulick AM. (2025) Protein Engineering of Biosynthetic Enzymes Unlocks Libraries of Bioactive Tilimycin Analogs. ACS catalysis (Nov), 15(21): 17801-17814.
Ogbu CP, Goldbach NM, Pacesa M, Kapoor S, Correia BE, Vecchio AJ. (2025) Structures of a synthetic antibody selected against and bound to the C-terminal domain of Clostridium perfringens enterotoxin. Protein science : a publication of the Protein Society (Oct), 34(10): e70281.
Pacesa M, Nickel L, Schellhaas C, Schmidt J, Pyatova E, Kissling L, Barendse P, Choudhury J, Kapoor S, Alcaraz-Serna A, Cho Y, Ghamary KH, Vinué L, Yachnin BJ, Wollacott AM, Buckley S, Westphal AH, Lindhoud S, Georgeon S, Goverde CA, Hatzopoulos GN, Gönczy P, Muller YD, Schwank G, Swarts DC, Vecchio AJ, Schneider BL, Ovchinnikov S, Correia BE. (2025) One-shot design of functional protein binders with BindCraft. Nature (Aug)
Vasireddy PCR, Low-Beer T, Spoth KA, Acehan D, Crawley MR, Martynowycz MW. (2025) Direct from the Seed: An Atomic-Resolution Protein Structure by Ab Initio MicroED. bioRxiv : the preprint server for biology (Jul).
Fisk MB, Barrera Ramirez J, Merrick CE, Wencewicz TA, Gulick AM. (2025) Identification and Characterization of the Biosynthesis of the Hybrid NRPS-NIS Siderophore Nocardichelin. ACS chemical biology (Jun).
Ogbu CP, de Las Alas M, Mandriota AM, Liu X, Kapoor S, Choudhury J, Ruma YN, Goodman MC, Sanders CR, Gonen T, Kossiakoff AA, Duffey ME, Vecchio AJ. (2025) Biophysical basis of tight junction barrier modulation by a pan-claudin-binding molecule. PNAS nexus (Jun), 4(6): pgaf189.
Kahlert L, Patel KD, Lichstrahl MS, Li R, He C, Gulick AM, Townsend CA. (2025) l-2,3-Diaminopropionate Binding Mode of the SulM Adenylation Domain Limits Engineering Monobactam Analogue Biosynthesis with Larger Substrates. JACS Au (Apr), 5(4): 1992-2003.
MacDonald MR, Gulick AM. (2025) An Efficient Lysate-Based Approach for Biosynthesis of the Pyrrolobenzodiazepine Natural Product Tilimycin. Journal of Biotechnology (Mar)
Ahmed SF, Gulick AM. (2025) The Structural Basis of Substrate Selectivity of the Acinetobactin Biosynthetic Adenylation Domain, BasE. The Journal of Biological Chemistry (Mar)108413.
Zuo X, Jussupow A, Ponomarenko NS, Grant TD, Tefft NM, Yadav NS, Range KL, Ralston CY, TerAvest MA, Sutter M, Kerfeld CA, Vermaas JV, Feig M, Tiede DM. (2025) Structure Characterization of Bacterial Microcompartment Shells via X-ray Scattering and Coordinate Modeling: Evidence for Adventitious Capture of Cytoplasmic Proteins. ACS applied bio materials (Mar), 8(3): 2090-2103.
Clabbers MTB, Hattne J, Martynowycz MW, Gonen T. (2025) Energy filtering enables macromolecular MicroED data at sub-atomic resolution. Nature communications (Mar), 16(1): 2247.
Clabbers MTB, Hattne J, Martynowycz MW, Gonen T. (2025) Publisher Correction: Energy filtering enables macromolecular MicroED data at sub-atomic resolution.
Nicolas WJ, Shiriaeva A, Martynowycz MW, Grey AC, Ruma YN, Donaldson PJ, Gonen T. (2025) Structure of the lens MP20 mediated adhesive junction. Nature communications (Mar), 16(1): 2977.
Clark ND, Li C, Malkowski MG. (2025) Structural insights into the role of the prosegment binding loop in a papain-superfamily cysteine protease from Treponema denticola. Acta crystallographica. Section F, Structural biology communications (Feb).
Dong L, Malkowski MG. (2025) Coupling Subunit-Specific States to Allosteric Regulation in Homodimeric Cyclooxygenase-2. Biochemistry (Feb).
Clabbers MTB, Hattne J, Martynowycz MW, Gonen T. (2025) Characterization of energy filtering slit widths for MicroED data collection. bioRxiv : the preprint server for biology (Feb).

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Recent Faculty Publications

Jacobs School of Medicine and Biomedical Sciences

Join the School

Get Involved

Find People

UB Health Sciences

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About The School

Centers and Affiliations

Education and Training

Research Facilities and Services

Health Care

Resources by Audience

Alumni and Friends

Governance

Learning Resources

Support Services

Site Tools

Jacobs School of Medicine and Biomedical Sciences