Recent Faculty Publications

We share our research studies with physicians and scientists worldwide through publications in leading academic journals.

Meena JK, Wang JH, Neill NJ, Keough D, Putluri N, Katsonis P, Koire AM, Lee H, Bowling EA, Tyagi S, Orellana M, Dominguez-Vidaña R, Li H, Eagle K, Danan C, Chung HC, Yang AD, Wu W, Kurley SJ, Ho BM, Zoeller JR, Olson CM, Meerbrey KL, Lichtarge O, Sreekumar A, Dacso CC, Guddat LW, Rejman D, Hocková D, Janeba Z, Simon LM, Lin CY, Pillon MC, Westbrook TF. (2024) MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer discovery (Sep), 14(9): 1699-1716. doi:10.1158/2159-8290.CD-22-0649
Rathnayake SS, Erramilli SK, Kossiakoff AA, Vecchio AJ. (2024) Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Structure (Sep)S0969-2126(24)00384-8. doi:10.1016/j.str.2024.09.015
Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, and Correia BE. (2024) Computational design of soluble and functional membrane protein analogues. Nature (Jul), 8020(631) doi:doi: 10.1038/s41586-024-07601-y
Rathnayake SS, Erramilli SK, Kossiakoff AA, and Vecchio AJ. (2024) Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4. bioRxiv (Jul)(2024.07.11.603128) doi:doi: https://doi.org/10.1101/2024.07.11.603128
Aragon M, Bowman SEJ, Chen CH, Cruz MJ, Decato DA, Eng ET, Flatt KM, Gulati S, Li Y, Lomba CJ, Mercado B, Miller J, Palatinus L, Rice WJ, Waterman D, Zimanyi CM. (2024) Applying 3D ED/MicroED workflows toward the next frontiers. Acta crystallographica. Section C, Structural chemistry (Jun).
Erramilli SK, Dominik PK, Ogbu CP, Kossiakoff AA, and Vecchio AJ. (2024) Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol (Jun), 733(7) doi:https://doi.org/10.1038/s42003-024-06437-6.
Patel KD, Oliver RA, Lichstrahl MS, Li R, Townsend CA, Gulick AM. (2024) The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain. The Journal of Biological Chemistry (Jun)107489.
Nicolas WJ, Shiriaeva A, Martynowycz MW, Grey AC, Ruma Y, Donaldson PJ, Gonen T. (2024) Structure of the lens MP20 mediated adhesive junction. bioRxiv : the preprint server for biology (May). doi:10.1101/2024.05.13.594022
Xia X, Sung PY, Martynowycz MW, Gonen T, Roy P, Zhou ZH. (2024) RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells. Cell (Apr), 187(9): 2236-2249.e17. doi:10.1016/j.cell.2024.03.007
Bardin AA, Haymaker A, Banihashemi F, Lin JYS, Martynowycz MW, Nannenga BL. (2024) Focused ion beam milling and MicroED structure determination of metal-organic framework crystals. Ultramicroscopy (Mar), 257: 113905. doi:10.1016/j.ultramic.2023.113905
Babbitt GA, Rajendran M, Lynch ML, Asare-Bediako R, Mouli LT, Ryan CJ, Srivastava H, Rynkiewicz P, Phadke K, Reed ML, Moore N, Ferran MC, Fokoue EP. (2024) ATOMDANCE: Kernel-based denoising and choreographic analysis for protein dynamic comparison. Biophysical journal (Mar).
Gulick AM, Mydy LS, Patel KD. (2024) Kinetic analysis of the three-substrate reaction mechanism of an NRPS-independent siderophore (NIS) synthetase. Methods in enzymology (Jan), 702: 1-19. doi:10.1016/bs.mie.2024.06.012
Haymaker A, Bardin AA, Gonen T, Martynowycz MW, Nannenga BL. (2023) Structure determination of a DNA crystal by MicroED. Structure (London, England : 1993) (Dec), 31(12): 1499-1503.e2. doi:10.1016/j.str.2023.07.005
Chamberlain SR, Moore S, Grant TD. (2023) Fitting high-resolution electron density maps from atomic models to solution scattering data. Biophysical Journal (Dec), 122(39): 4567-4581. doi:10.1016/j.bpj.2023.10.034
Hattne J, Clabbers MTB, Martynowycz MW, Gonen T. (2023) Electron counting with direct electron detectors in MicroED. Structure (London, England : 1993) (Dec), 31(12): 1504-1509.e1. doi:10.1016/j.str.2023.10.011
Primeaux M., Liu X., Gowrikumar S., Fatima I., Fisher K.W., Bastola D., Vecchio A.J., Singh A.B., and Dhawan P. (2023) Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer. Cancer Letters (Nov), 579(28): 216479. doi:10.1016/j.canlet.2023.216479
Khan F, Elgeti M, Grandfield S, Paz A, Naughton FB, Marcoline FV, Althoff T, Ermolova N, Wright EM, Hubbell WL, Grabe M, Abramson J. (2023) Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT. Nature communications (Nov), 14(1): 7511. doi:10.1038/s41467-023-43119-z
Ishigami I, Carbajo S, Zatsepin N, Hikita M, Conrad CE, Nelson G, Coe J, Basu S, Grant T, Seaberg MH, Sierra RG, Hunter MS, Fromme P, Fromme R, Rousseau DL, Yeh SR. (2023) Detection of a Geminate Photoproduct of Bovine Cytochrome c Oxidase by Time-Resolved Serial Femtosecond Crystallography. J Am Chem Soc (Oct), 145(41): 22305-22309. doi:10.1021/jacs.3c07803
Dong L, Malkowski MG. (2023) Defining the Conformational Ensembles Associated with Ligand Binding to Cyclooxygenase-2. Biochemistry (Oct), 62: 3134-3144.
Ogbu C.P., Kapoor S., Vecchio A.J. (2023) Structural basis of Clostridium perfringens enterotoxin activation and oligomerization by trypsin. Toxins (Basel) (Oct), 15(31): 11. doi:10.3390/toxins15110637

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