Recent Faculty Publications

We share our research studies with physicians and scientists worldwide through publications in leading academic journals.

Patel KD, Gulick AM. (2023) Structural and functional insights into d-poly-L-ornithine polymer biosynthesis from Acinetobacter baumannii. Communications Biology (Sep), 6(1): 982. doi:10.1038/s42003-023-05362-4
Erramilli SK, Dominik PK, Ogbu CP, Kossiakoff AA, Vecchio AJ. (2023) Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin. bioRxiv : the preprint server for biology (Jun). doi:10.1101/2023.06.12.544689
Patel KD, MacDonald MR, Ahmed SF, Singh J, Gulick AM. (2023) Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases. Natural Product Reports (Apr)(40): 1550-1582. doi:10.1039/d3np00003f
Fatima I, Uppada JP, Chhonker YS, Gowrikumar S, Barman S, Roy S, Tolentino KT, Palermo N, Natarajan A, Beauchamp DR, Vecchio A, Murry DJ, Singh AB, Hopkins CR, Dhawan P. (2023) Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Mar), 159: 114255.
Jernigan RJ, Logeswaran D, Doppler D, Nagaratnam N, Sonker M, Yang JH, Ketawala G, Martin-Garcia JM, Shelby ML, Grant TD, Mariani V, Tolstikova A, Sheikh MZ, Yung MC, Coleman MA, Zaare S, Kaschner EK, Rabbani MT, Nazari R, Zacks MA, Hayes B, Sierra RG, Hunter MS, Lisova S, Batyuk A, Kupitz C, Boutet S, Hansen DT, Kirian RA, Schmidt M, Fromme R, Frank M, Ros A, Chen JJ, Botha S, Fromme P. (2023) Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser. Structure (London, England : 1993) (Feb), 31(2): 138-151.e5. doi:10.1016/j.str.2022.12.009
Grant TD. (2023) Reconstruction of 3D density from solution scattering. Methods in enzymology (Jan), 678: 145-192.
Patel KD, Ahmed SF, MacDonald MR, Gulick AM. (2023) Structural Studies of Modular Nonribosomal Peptide Synthetases. Methods in Molecular Biology (Clifton, N.J.) (Jan), 2670: 17-46.
Sonker M, Doppler D, Egatz-Gomez A, Zaare S, Rabbani MT, Manna A, Cruz Villarreal J, Nelson G, Ketawala GK, Karpos K, Alvarez RC, Nazari R, Thifault D, Jernigan R, Oberthür D, Han H, Sierra R, Hunter MS, Batyuk A, Kupitz CJ, Sublett RE, Poitevin F, Lisova S, Mariani V, Tolstikova A, Boutet S, Messerschmidt M, Meza-Aguilar JD, Fromme R, Martin-Garcia JM, Botha S, Fromme P, Grant TD, Kirian RA, Ros A. (2022) Electrically stimulated droplet injector for reduced sample consumption in serial crystallography. Biophysical reports (Dec), 2(4): 100081. doi:10.1016/j.bpr.2022.100081
Thomas D. Grant. (2022) Describing small-angle scattering profiles by a limited set of intensities. Journal of Applied Crystallography (Oct), 55(5): 1116-1124. doi:10.1107/S1600576722006598
Orlando BJ, Dominik PK, Roy S, Ogbu CP, Erramilli SK, Kossiakoff AA, Vecchio AJ. (2022) Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. The Journal of biological chemistry (Sep), 298(9): 102357. doi:10.1016/j.jbc.2022.102357
Nagaratnam N, Martin-Garcia JM, Yang JH, Goode MR, Ketawala G, Craciunescu FM, Zook JD, Sonowal M, Williams D, Grant TD, Fromme R, Hansen DT, Fromme P. (2022) Structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis. PLoS One (Aug), 17(8): e0267370. doi:10.1371/journal.pone.0267370
Yang J, Banas VS, Patel KD, Rivera GSM, Mydy LS, Gulick AM, Wencewicz TA. (2022) An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. The Journal of Biological Chemistry (Jun)102166.
Ogbu CP, Roy S, Vecchio AJ. (2022) Disruption of Claudin-Made Tight Junction Barriers by Clostridium perfringens Enterotoxin: Insights from Structural Biology. Cells (Mar), 11(5). doi:10.3390/cells11050903
Doppler D, Rabbani MT, Letrun R, Cruz Villarreal J, Kim DH, Gandhi S, Egatz-Gomez A, Sonker M, Chen J, Koua FHM, Yang J, Youssef M, Mazalova V, Bajt S, Shelby ML, Coleman MA, Wiedorn MO, Knoska J, Schön S, Sato T, Hunter MS, Hosseinizadeh A, Kuptiz C, Nazari R, Alvarez RC, Karpos K, Zaare S, Dobson Z, Discianno E, Zhang S, Zook JD, Bielecki J, de Wijn R, Round AR, Vagovic P, Kloos M, Vakili M, Ketawala GK, Stander NE, Olson TL, Morin K, Mondal J, Nguyen J, Meza-Aguilar JD, Kodis G, Vaiana S, Martin-Garcia JM, Mariani V, Schwander P, Schmidt M, Messerschmidt M, Ourmazd A, Zatsepin N, Weierstall U, Bruce BD, Mancuso AP, Grant T, Barty A, Chapman HN, Frank M, Fromme R, Spence JCH, Botha S, Fromme P, Kirian RA, Ros A. (2022) Co-flow injection for serial crystallography at X-ray free-electron lasers. Journal of applied crystallography (Feb), 55(Pt 1): 1-13. doi:10.1107/S1600576721011079
Bony BA, Tarudji AW, Miller HA, Gowrikumar S, Roy S, Curtis ET, Gee CC, Vecchio A, Dhawan P, Kievit FM. (2021) Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood-Brain Barrier. ACS nano (Nov), 15(11): 18520-18531. doi:10.1021/acsnano.1c08432
Koeller CM, Smith TK, Gulick AM, Bangs JD. (2021) p67: a cryptic lysosomal hydrolase in Trypanosoma brucei?. Parasitology (Sep), 148(10): 1271-1276.
Patel KD, Gulick AM. (2021) Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire. The Journal of Biological Chemistry (Aug), 297(3): 101047.
Vecchio AJ, Rathnayake SS, Stroud RM. (2021) Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut. Proceedings of the National Academy of Sciences of the United States of America (Apr), 118(15). doi:10.1073/pnas.2024651118
Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL, Stephens J, Greene D, Hanif M, O. (2021) Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function. Haematologica (Mar), 106(5): 1423-1432. doi:10.3324/haematol.2019.235895
Grant TD. (2021) Reply to: Limitations of the iterative electron density reconstruction algorithm from solution scattering data. Nature methods (Mar), 18(3): 246-248.

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