Recent Faculty Publications

We share our research studies with physicians and scientists worldwide through publications in leading academic journals.

Kahlert L, Patel KD, Lichstrahl MS, Li R, He C, Gulick AM, Townsend CA. (2025) l-2,3-Diaminopropionate Binding Mode of the SulM Adenylation Domain Limits Engineering Monobactam Analogue Biosynthesis with Larger Substrates. JACS Au (Apr), 5(4): 1992-2003.
MacDonald MR, Gulick AM. (2025) An Efficient Lysate-Based Approach for Biosynthesis of the Pyrrolobenzodiazepine Natural Product Tilimycin. Journal of Biotechnology (Mar)
Ahmed SF, Gulick AM. (2025) The Structural Basis of Substrate Selectivity of the Acinetobactin Biosynthetic Adenylation Domain, BasE. The Journal of Biological Chemistry (Mar)108413.
Clark ND, Li C, Malkowski MG. (2025) Structural insights into the role of the prosegment binding loop in a papain-superfamily cysteine protease from Treponema denticola. Acta crystallographica. Section F, Structural biology communications (Feb).
Dong L, Malkowski MG. (2025) Coupling Subunit-Specific States to Allosteric Regulation in Homodimeric Cyclooxygenase-2. Biochemistry (Feb).
Kurniyati K, Clark ND, Wang H, Deng Y, Sze CW, Visser MB, Malkowski MG, Li C. (2025) A bipartite bacterial virulence factor targets the complement system and neutrophil activation. The EMBO journal (Jan).
Pacesa M, Nickel L, Schellhaas C, Schmidt J, Pyatova E, Kissling L, Barendse P, Choudhury J, Kapoor S, Alcaraz-Serna A, Cho Y, Ghamary KH, Vinué L, Yachnin BJ, Wollacott AM, Buckley S, Westphal AH, Lindhoud S, Georgeon S, Goverde CA, Hatzopoulos GN, Gönczy P, Muller YD, Schwank G, Swarts DC, Vecchio AJ, Schneider BL, Ovchinnikov S, Correia BE. (2024) BindCraft: one-shot design of functional protein binders. bioRxiv : the preprint server for biology (Dec) doi:10.1101/2024.09.30.615802
Liu X, Xia X, Martynowycz MW, Gonen T, Zhou ZH. (2024) Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication. Nature communications (Dec), 15(1): 10638. doi:10.1038/s41467-024-54968-7
Nicolas WJ, Gillman C, Weaver SJ, Clabbers MTB, Shiriaeva A, Her AS, Martynowycz MW, Gonen T. (2024) Comprehensive microcrystal electron diffraction sample preparation for cryo-EM. Nature protocols (Dec).
Patel KD, Fisk MB, Gulick AM. (2024) Discovery, functional characterization, and structural studies of the NRPS-independent siderophore synthetases. Critical Reviews in Biochemistry and Molecular Biology (Dec), 59(6): 447-471.
Ahmed SF, Balutowski A, Yang J, Wencewicz TA, Gulick AM. (2024) Expanding the Substrate Selectivity of the Fimsbactin Biosynthetic Adenylation Domain, FbsH. ACS chemical biology (Nov).
Ogbu CP, Mandriota AM, Liu X, de Las Alas M, Kapoor S, Choudhury J, Kossiakoff AA, Duffey ME, Vecchio AJ. (2024) Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule. bioRxiv : the preprint server for biology (Nov) doi:10.1101/2024.11.10.622873
Meena JK, Wang JH, Neill NJ, Keough D, Putluri N, Katsonis P, Koire AM, Lee H, Bowling EA, Tyagi S, Orellana M, Dominguez-Vidaña R, Li H, Eagle K, Danan C, Chung HC, Yang AD, Wu W, Kurley SJ, Ho BM, Zoeller JR, Olson CM, Meerbrey KL, Lichtarge O, Sreekumar A, Dacso CC, Guddat LW, Rejman D, Hocková D, Janeba Z, Simon LM, Lin CY, Pillon MC, Westbrook TF. (2024) MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer discovery (Sep), 14(9): 1699-1716. doi:10.1158/2159-8290.CD-22-0649
Rathnayake SS, Erramilli SK, Kossiakoff AA, Vecchio AJ. (2024) Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Structure (Sep)S0969-2126(24)00384-8. doi:10.1016/j.str.2024.09.015
Clabbers MTB, Hattne J, Martynowycz MW, Gonen T. (2024) Energy filtering enables macromolecular MicroED data at sub-atomic resolution. bioRxiv : the preprint server for biology (Aug). doi:10.1101/2024.08.29.610380
Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, and Correia BE. (2024) Computational design of soluble and functional membrane protein analogues. Nature (Jul), 8020(631) doi:doi: 10.1038/s41586-024-07601-y
Rathnayake SS, Erramilli SK, Kossiakoff AA, and Vecchio AJ. (2024) Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4. bioRxiv (Jul)(2024.07.11.603128) doi:doi: https://doi.org/10.1101/2024.07.11.603128
Patel KD, Oliver RA, Lichstrahl MS, Li R, Townsend CA, Gulick AM. (2024) The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain. The Journal of Biological Chemistry (Jun)107489.
Erramilli SK, Dominik PK, Ogbu CP, Kossiakoff AA, and Vecchio AJ. (2024) Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol (Jun), 733(7) doi:https://doi.org/10.1038/s42003-024-06437-6.
Nicolas WJ, Shiriaeva A, Martynowycz MW, Grey AC, Ruma Y, Donaldson PJ, Gonen T. (2024) Structure of the lens MP20 mediated adhesive junction. bioRxiv : the preprint server for biology (May). doi:10.1101/2024.05.13.594022

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