Graeme Frost

Graeme Frost.

Graeme Frost

Graeme Frost

Thesis Title

TBD

Publications Overview

Publications

  • Dutta, D., Kanca, O., Shridharan, R. V., Marcogliese, P. C., Steger, B., Morimoto, M., Frost, F. G.... & Bellen, H. J. (2024). Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Proceedings of the National Academy of Sciences, 121(9) 
  • Frost, F. G., Morimoto, M., Sharma, P., Ruaud, L., Belnap, N., Calame, D. G., ... & Malicdan, M. C. V. (2023). Bi-allelic SNAPC4 variants dysregulate global alternative splicing and lead to neuroregression and progressive spastic paraparesis. The American Journal of Human Genetics, 110(4), 663-680. 
  • Gazzaz, N. *, Frost, F. G.*, Dalmann, J., Alderman, E., Richmond, P.A., Lin, S., Salman, A., Lehman, A., Turvey, S., Boerkoel, C. F., Cherukuri, P. F. (Accepted June 2022) Can tandem alternative splicing and evasion of premature termination codon surveillance contribute to attenuated Peutz-Jeghers Syndrome? American Journal of Medical Genetics *These authors contributed equally 
  • Cherukuri, P. F., Soe, M. M., Condon, D. E., Bartaria, S., Meis, K., Gu, S., Frost, F. G., Fricke, L. M., Lubieniecki, K. P., Lubieniecka, J. M., Pyatt, R. E., Hajek, C., Boerkoel, C. F., & Carmichael, L. (2022). Establishing analytical validity of BeadChip array genotype data by comparison to whole-genome sequence and standard benchmark datasets. BMC Medical Genomics, 15(1), 56. 
  • Frost, F. G., Cherukuri, P. F., Milanovich, S., & Boerkoel, C. F. (2020). Pan‐cancer RNA‐seq data stratifies tumours by some hallmarks of cancer. Journal of Cellular and Molecular Medicine, 24(1), 418–430. 
  • Engdahl, T. B.*, Frost, F. G.*, Schech, A. J., & Elliott, S. L. (2019). Viability and migratory effects of IGF-1R inhibitor, PQ401, on triple negative breast cancer cells. BIOS, 90(1), 14–19. *These authors contributed equally 
  • Vasta, G. R., Feng, C., González-Montalbán, N., Mancini, J., Yang, L., Abernathy, K., Frost, G., & Palm, C. (2017). Functions of galectins as ‘self/non-self’-recognition and effector factors. Pathogens and Disease, 75(5).

Professional/Educational Meetings/Abstracts

  • Frost, G., S. Gu, A. Elbert, M. Malicdan, C. Boerkoel, P. Cherukuri (November 2023) Pathogenic tandem splice acceptor variants escape screening by in silico tools. Presented at the American Society of Human Genetics (ASHG) meeting in November 2023, Washington, DC. 
  • Frost, G., M. Morimoto, P. Sharma, N. Belnap, D. Calame, Y. Uchiyama, N. Matsumoto, M. Oud, E. A. Ferreira, V. Narayanan, S. Rangasamy, M. Huentelman, K. Ramsey, L. T. Emrick, I. Sato-Shirai, S. Kumada, N. I. Wolf, P. J. Steinbach, Y. Huang, Undiagnosed Diseases Network, J. L. Murphy, J. R. Lupski, G. Vezina, E. F. Macnamara, D. R. Adams, M. T. Acosta, C. J. Tifft, W. A. Gah, M. V. Malicdan (November 2022) Deleterious SNAPC4 Variants are Associated with a Neurodevelopmental Disorder. Presented at the American Society of Human Genetics (ASHG) meeting in November 2022, Los Angeles, CA. 
  • Frost, G. Sharma, P., Morimoto, M., Belnap, N., Calame, D., Narayanan, V., Rangasamy, S., Huentelman, M., Ramsey, K., Lupski, J., Steinbach, P., Undiagnosed Diseases Network, Murphy, J., Macnamara, E., Tifft, C., Gahl, W., Malicdan, M.C.V. (October 2021) Impaired SNAPC4 function leads to global reduction of canonical splicing events and is associated with a disorder characterized by progressive spasticity, developmental delay, and speech dysarthria. Presented at the virtual American Society of Human Genetics (ASHG) meeting in October 2021. 
  • Frost, G. Sharma, P., Morimoto, M., Belnap, N., Calame, D., Steinbach, P., Undiagnosed Diseases Network, Murphy, J., Tifft, C., Gahl, W., Malicdan, M.C.V. (April 2021) A Progressive Neurological Disorder in Patients With SNAPC4 Variants. Poster presented at the National Institutes of Health (NIH) Virtual Postbac Poster Day in April 2021, Bethesda, Maryland. 
  • Frost, G., Sharma, P., Morimoto, M., Belnap, N., Steinbach, P.J., Undiagnosed Diseases Network, Murphy, J.L., Tifft, C.J., Gahl, W.A., Malicdan, M.C.V. (October 2020) SNAPC4 variants are associated with a pediatric neurological disorder characterized by progressive neuromuscular spasticity, developmental delay, and speech dysarthria. Presented at the virtual American Society of Human Genetics (ASHG) meeting in October 2020. 
  • Frost, G. Sharma, P., Morimoto, M., Belnap, N., Steinbach, P., Undiagnosed Diseases Network, Murphy, J., Tifft, C., Gahl, W., Malicdan, M.C.V. (April 2020) Loss-of-Function Variants in SNAPC4 are Associated with Progressive Muscle Spasticity. Poster presented at the National Institutes of Health (NIH) Virtual Postbac Poster Day in April 2020, Bethesda, Maryland. 
  • Frost, G., Cherukuri, P., Lubienecka, J., UCSC Treehouse Childhood Cancer Initiative, Milanovich, S., and Boerkoel, C. (October 2018) Tumor gene expression profiles segregate across primary sites. Poster presented at the annual American Society of Human Genetics (ASHG) meeting in October 2018, San Diego, California. 
  • Mancini, J., González-Montalbán, N., Palm, C., Frost, G., Feng, C., and Vasta, G.R. (June 2016) Extracellular tandem repeat galectin (DrGal9-L1) from zebrafish promotes adhesion and infection of IHNV (infectious hematopoetic necrosis virus) in vitro infection. Poster presented at the NIH & FDA Glycoscience Research Day in June 2016, Bethesda, MD.