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Immunology

Elizabeth Wohlfert, PhD

Elizabeth Wohlfert, PhD, focuses her research on the intestinal immune system. She aims to understand regulatory mechanisms during infection and autoimmunity at mucosal sites, particularly within the gastrointestinal tract.

Our immunology research intersects with explorations of various disease-causing pathogens, incorporating molecular processes, cancer immunology and infectious disease. We study host immune responses to parasitic and microbial infection. We also explore immunity and immune regulation at mucosal sites, mucosal vaccine adjuvants and vaccine development.

Focus on Tumor Immunology, Host Pathogen Interactions and Immunity at Mucosal Sites

Our research focuses on the mechanisms by which bacterial products and bacterial pathogens modulate immune responses in the host.  

We are working to develop immune adjuvants for vaccine development against HIV, pneumococci and other pathogens. We also aim to identify bacterial genes and gene products that elicit or exacerbate symptoms of Crohn’s disease and inflammatory bowel disease.

We also are evaluating the potential of bacterial enterotoxins to combat breast cancer.

Other projects aim to understand mechanisms of immune regulation in mucosal tissues. We study regulatory T cells (Tregs) during infections with parasites to understand how they adapt to, and function within, inflammatory environments. The goal is to better understand Treg adaptation so we can target these cells for therapeutic purposes.   

We aim to determine the cell types and factors in human tumor microenvironments that inhibit the ability of patients’ T cells to recognize and kill tumor cells. Upon recognizing the immune suppressive factors, we then design methods to block or reverse the T cell inhibitory activity, thereby enhancing T cell killing and tumor eradication.

We explore how immune responses to parasitic infections in the central nervous system affect the function and survival of neurons.

We also study biological functions of IgA antibodies and the generation of mucosal immune responses, especially against bacterial infections of the mouth and genital tract.

Research News

Anthony A. Campagnari, PhD, ’84
6/6/16

Anthony A. Campagnari, PhD ’84, senior associate dean for research and graduate education, has received the 2016 Stockton Kimball Award for outstanding scientific achievement and service.

Michael W. Russell, PhD
6/10/15

In the fight against infectious disease, University at Buffalo immunologist Michael W. Russell, PhD, professor of microbiology and immunology, advocates a novel alternative to antibiotics and vaccines: directly target the immune system.

Kate Rittenhouse-Olson, PhD
6/8/15
For-Robin, a company founded and led by a Kate Rittenhouse-Olson, PhD, will further study and develop a promising potential cancer treatment.
10/6/14

Research led by a student in UB’s Medical Scientist Training Program is featured on the cover of the world’s most frequently cited cancer journal.

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Department Faculty

Bankert, Richard
Richard Bankert, VMD, PhD
Professor of Microbiology

Blader, Ira
Ira Blader, PhD
Professor

Connell, Terry
Terry Connell, PhD
Professor of Microbiology and Immunology, Adjunct Professor of Oral Biology

Kelleher, Raymond
Raymond Kelleher, PhD
Research Associate Professor

Wohlfert, Elizabeth
Elizabeth Wohlfert, PhD
Assistant Professor