Basic Research
Mark D. Hicar, MD, PhD, runs a basic research laboratory that searches for the cause of several pediatric diseases.
Basic research uncovers fundamental biological mechanisms and disease processes, providing the critical knowledge needed to inform translational research and develop potential disease treatments, diagnostics, or prevention sttrategies.
Leading the Way in Medical Discoveries
At the CMHRI, basic science research forms the foundation for innovation in maternal and child health. Our investigators are exploring the cellular, genetic, and molecular mechanisms that drive diseases affecting children and mothers. From the biology of early development to the immunological underpinnings of infectious disease, our research spans disciplines and technologies, including high-throughput genomics, advanced imaging, and precision medicine tools.
The CMHRI supports collaborations between laboratory scientists, clinicians, and engineers to foster discovery that can be translated into new diagnostics and therapies. Key areas of basic science focus include: immunology and infectious disease (Kawaski's Disease, Lyme Disease, MISC, and HIV) genetic mutations like FOXG1, diabetes pathophysiology, pediatric cardiomyopathies, and neonatal respiratory physiology. Through mentorship and integration with UB’s Core Facilities (e.g., Genomics, Flow Cytometry, and Biobank) our basic researchers contribute to a seamless pipeline of discovery that improves care for the most vulnerable populations.