This elective course will cover topics in cellular signaling, including G protein-coupled receptors as well as growth factors and their receptors — including nuclear FGFR1. Other topics to be covered include mTOR signaling and neurological disease; the unfolded protein response and diabetes; and changes in signaling leading to polycystic kidney disease. The contribution of the microenvironment to cellular signaling will be studied, including the pathways that promote tissue remodeling, wound healing and cancer.