“Emerging role of MECOM on AR activity in Treatment-Resistant Prostate Cancer”
Date: Monday, April 29
Time: 4:00 p.m.
Location: Jacobs School of Medicine and Biomedical Sciences
955 Main St., Room 2220B
Summary: The androgen receptor (AR) is a hormone nuclear receptor that functions as a transcription factor (TF) and a critical driver of prostate cancer pathogenesis. AR cistrome is extensively reprogrammed with prostate cancer progression and attracts other TFs to aid in cancer cell survival.
Our studies have identified MECOM as an MSD1-EVI1 complex and nuclear transcription factor uniquely over-expressed in treatment resistant prostate cancers and associated with a reprogrammed AR cistrome.
Join us for an informal science talk.
Free and open to the public.
coe-gem@buffalo.edu
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Remi Adelaiye-Ogala, PhD
Assistant Professor
Department of Medicine
Division of Hematology and Oncology