A letter written in the New England Journal of Medicine suggests prioritizing the first dose of the Moderna vaccine to the masses before a second dose. However, health experts warn that the letter may not be fully accurate. “That correspondence to the New England Journal was a sub-analysis of the data submitted to the U.S. Food and Drug Administration,” says
Kenneth V. Snyder, MD, PhD, assistant professor of
neurosurgery. “Whenever you look at data that wasn’t part of the primary outcome of a trial, you have to be very careful about quoting it as perfectly reproducible.”
John A. Sellick Jr., DO, professor of
medicine in the
Division of Infectious Diseases, agrees with Snyder, saying the letters were based on “fuzzy numbers” and not brand new numbers from a well-done study. “We have to be very careful extrapolating from a re-analysis of sub-groups from the original studies or these uncontrolled, just checking and seeing what some patients have shown, which is what happened in the study from Israel,” Sellick says.