Animesh A. Sinha MD, PhD

Animesh Sinha

Animesh A. Sinha
MD, PhD

Professor of Dermatology

Department of Dermatology

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Autoimmune Conditions; Autoimmunity; Clinical Informatics; Clinical Research; Dermatological Immunology; Dermatological Immunology – Clinical and Laboratory; Dermatology; Gene Expression; Gene Sequencing; Genomics and proteomics; Health Services Research; Immunology; Inflammation; Molecular Basis of Disease; Molecular genetics; Nanotechnology; Omics & Big Data; Patient Centered Outcomes; Preclinical Research; Proteomics; Real-world approaches; RNA; Transcription and Translation; Transcriptomics; Translational Research; Whole Genome Sequencing

Contact Information
6078 Clinical and Translational Research Center
875 Ellicott, Street
Buffalo, New York 14203
Phone: 716-842-2116
aasinha@buffalo.edu
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Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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Overview Research Publications Activities Latest News

Professional Summary:

My long-term research interests lie in the fields of immunological tolerance and autoimmunity. My laboratory concentrates on the inductive and regulatory events of the autoimmune pathway.

We are pursuing 4 major lines of investigation:

1. The investigation of i) HLA and ii) non-HLA genes that contribute to the autoimmune diathesis. We are employing standard and next-generational technologies to pinpoint diseases susceptibility loci in complex diseases with a multifactorial etiology. Our goal is to define the functional role of risk genes in disease development using in vitro and in vivo model systems.

2. The investigation of autoimmune induction and progression in the skin by the detailed study of the fine molecular interactions between MHC II-antigen-T cell receptor. Specifically, we are characterizing MHC- peptide complexes capable of triggering autoimmune T cells in pemphigus vulgaris. Our goal is to i) determine the process of self-epitope selection, ii) determine the frequency, phenotype and receptor repertoire of self-epitope reactive effector and regulatory T cells, and iii) determine the functional interplay between T and B lymphocytes that controls the production of pathogenic auto-antibodies.

3. The investigation of biological pathways and networks that contribute to the development of autoimmunity in the skin disease via integrated systems biology based strategies and high throughput technologies. Specifically, we are employing microarray platforms to identify disease susceptibility genes and to define transcriptional profiles and proteomic biomarkers in the skin and blood of patients. Our goal is to illuminate genomic and proteomic programs relevant for i) disease induction, ii) disease progression, and iii) response to therapy.

4. The investigation of autoimmune pathology at the nanoscale. Specifically, we are developing and applying cutting-edge nanorobotic technologies to link nanostructural changes at the cell surface to functional events associated with autoimmune events in the skin. Our goal is to develop advanced technology to i) provide a new level of detail regarding cellular and molecular mechanisms of autoimmunity, ii) predict cellular behavior and investigate mechanisms relevant to the development and progression of autoimmune responses, and iii) screen for novel therapeutic agents operational at the tissue level.


The common goal of the studies outlined above is to develop improved tools that support rational clinical decision making for disease diagnosis and prognosis, and further to uncover novel targets for immune intervention and potentially gene therapy in autoimmune disease to provide personalized and precision medicine.

Education and Training:
  • Certificate, Certified Medical Educator, UB/Royal College of Physicians (2015)
  • Residency, Dermatology Residency, Yale University (1998)
  • Residency, Dermatology Residency, University of Alberta (1995)
  • Fellowship, Research Fellowship (Immunology), Stanford University (1992)
  • PhD, Medical Sciences (Immunology), University of Alberta (1986)
  • MD, University of Alberta (1982)

Employment:
  • Professor, Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (2017-present)
  • Member, Genetics, Genomics, and Bioinformatics Program, University at Buffalo (2013-present)
  • Adjunct Faculty Appointment, Biochemistry, University at Buffalo (2011-present)
  • Adjunct Faculty Appointment, Microbiology and Immunology, University at Buffalo (2011-present)
  • Associate Professor, Dermatology, Cornell University (2005-present)
  • Program Director of Residency Training, Dermatology, Jacobs School of Medicine and Biomedical Sciences (2012–2017)
  • Professor and Chair, Dermatology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011–2017)
  • Rita M. and Ralph T. Endowed Chair, Dermatology, Jacobs School of Medicine and Biomedical Sciences (2011–2017)
  • Associate Professor, Dermatology, Michigan State University (2005–2011)
  • Chief, Division of Dermatology and Cutaneous Sciences, Michigan State University (2005–2011)
  • Director, Michigan State University, Center for Investigative Dermatology (2005–2011)
  • Director, Dermatology, Michigan State University (2005–2011)
  • Program Director of Residency Training, Dermatology, Weill-Cornell Medical College (2004–2005)
  • Director, Cornell Dermatology Grand Rounds Lecture Series (2000–2005)
  • Oncology Executive Council, New York-Presbyterian Hospital (2000–2005)
  • Assistant Professor, Dermatology, Cornell University (1998–2005)
  • Associate Scientist, Dermatology, Yale University (1995–1998)
  • Associate Scientist, Medicine, University at Alberta (1992–1995)
  • Research Fellow, Microbiology and Immunology, Stanford University (1986–1992)
  • Research Fellow, University of Alberta (1982–1986)
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Awards and Honors:
  • Faculty Inductee (2024)
  • Fellow, Clinical and Translational Research Center, University at Buffalo (2012)
  • Doctor of the Year/Excellence in Research Award, (2009)
  • Women's Dermatology Society Mentorship Award (1997)
  • Medical Research Council of Canada Centennial Fellowship Award (1989)
  • AHFMR Independent Research Allowance Fellowship Award (1986)
  • AHFMR Part-time Studentship Award (1982)
  • Alberta Heritage Foundation for Medical Research Summer Studentship Award (1982)
  • Searle Research Scholarship in Pharmacology (1979)
  • Province of Alberta Scholarship (1976 - 1978)
  • Arthritis Foundation Fellowship Award (1989 - 1990)
  • Arthritis Foundation Investigator Award (1990 - 1994)
  • Dermatology Foundation Career Development Award (2000 - 2003)
  • AHFMR Research Fellowship Award (1982 - 1986)

Research Expertise:
  • Immunological Tolerance and Autoimmunity.: To pinpoint targets for immune intervention and potentially gene therapy in autoimmune disease

Research Centers:
  • Clinical and Translational Research Center (CTRC)

UB 2020 Strategic Strengths:
  • Health and Wellness Across the Lifespan
  • Information and Computing Technology
  • Integrated Nanostructured Systems
  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:
  • April 2021–May 2025
    Parallel genetic and immune studies in conjunction with a phase III, multicenter, double blind study of Efgartigimod in Pemphigus
    ArgenX
    Role: Principal Investigator
  • December 2022–December 2023
    Smart photodynamic therapy for acne by reversible switchable intersystem crossing in pure organic molecules
    NIH/NIAMS
    Role: Consultant
  • July 2022–June 2023
    Preclinical safety and efficacy studies of medical device to support IND submission
    UB Center for Advanced Technology in Dig Data and Health Sciences (UB CAT)
    Role: Principal Investigator
  • October 2018–September 2021
    Ancillary Study to Syntimmune, Inc. clinical trial "A Phase 1b, Multicenter, Open-Label, Safety, Tolerability, and Activity Study of SYNT001 in Subjects with Chronic Pemphigus (Vulgaris or Foliaceus
    Syntimmune, Inc./Alexion Pharmaceuticals, Inc
    Role: Principal Investigator
  • January 2019–June 2021
    IL-13 receptor alpha 1 downregulation as a protective mechanism and therapeutic target in pemphigus vulgaris
    International Pemphigus and Pemphigoid Foundation
    Role: Principal Investigator
  • April 2012–March 2021
    Genetic and Immune Dysregulation in Complex Cutaneous Disease
    University at Buffalo Office of the Vice President for Research and Economic Development
    Role: Principal Investigator
  • September 2017–August 2019
    Ancillary Study to Immune Pharmaceuticals clinical trial "An open label, proof of concept study designed to evaluate the safety, efficacy, and pharmacodynamic effect of Bertilimumab in patients with newly diagnosed, moderate to extensive bullous Pemphigoid
    Immune Pharmacueticals, Inc.
    Role: Principal Investigator
  • April 2017–June 2019
    Deciphering the evolutionary and biomedical relationships between human genetic variation, skin microbiome and autoimmune/inflammatory disorders
    Genetics, Environment and Microbiome (GEM) Community of Excellence Award, University at Buffalo Office of the Vice President for Research and Economic Development
    Role: Co-Principal Investigator
  • April 2012–March 2013
    Novel Multiplex Autoantigen Arrays for Biomarker Discovery in Skin Autoimmunity
    Clinical and Translational Service Award, University at Buffalo Office of the Vice President for Research and Economic Development
    Role: Principal Investigator
  • January 2010–December 2011
    Monitoring Autoimmune Activity in Pemphigus
    Crescent Healthcare, Inc.
    Role: Co-Investigator
    $3,000
  • February 2007–January 2009
    Functional Analysis of IFN-Y Regulated OAS1 Over-Expression in Cutaneous LE
    Alliance for Lupus Research
    Role: Co-Investigator
    $75,000
  • February 2007–January 2009
    Mechanisms of Autoimmunity in the Skin
    Role: Co-Investigator
    $75,000
  • July 2004–June 2006
    Gene Expression Analysis in Vitiligo
    American Vitiligo Research Foundation
    Role: Co-Investigator
    $30,000
  • May 2002–December 2005
    Human Gene Expression Profiling in Vitiligo by Microarray
    National Vitiligo Foundation
    Role: Co-Investigator
    $30,000
  • January 2002–January 2005
    Identifying And Characterizing Human Skin Genes Using DNA Chip Technology
    Colgate-Palmolive, Co
    Role: Co-Investigator
    $75,000
  • July 2000–July 2004
    Genome Wide Expression Analysis in Lupus Erythematosus
    Mary Kirkland Center for Lupus Research
    Role: Co-Investigator
    $143,850
  • July 2001–June 2004
    Genetic Basis of Cutaneous Lupus Erthematosus
    Colleck Research Fund
    Role: Co-Investigator
    $400,000
  • February 2002–January 2004
    Genome Wide Expression Analysis in Psoriasis
    National Psoriasis Foundation
    Role: Co-Investigator
    $150,000
  • September 1998–September 2001
    Mapping of Genes for Alopecia Areata in the General Population
    NIH/NIAMS
    Role: Co-Investigator
    $150,000
  • July 1998–June 2001
    Genetic Basis of Autoimmunity
    Colleck Research Fund
    Role: Principal Investigator
    $390,000
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Journal Articles:

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Books and Book Chapters:

  • Paget, S, Gibofsky, A, A., Sulco, Beary, J, Sinha AA. (2006) Rash and Arthritis. In: Rash and Arthritis. Lippincot, Williams, and Wilkins, Inc., 109-122.
  • Sinha A.A, Shylankevich, M., Offers, M., Moesta, A., Lin, M, Diaz, L., Tigelaar, R., Janeway, C. (1999) A polymerase chain reaction-based approach in search of potential T-cell epitopes in Pemphigus Vulgaris. In: A polymerase chain reaction-based approach in search of potential T-cell epitopes in Pemphigus Vulgaris. Monduzzi Editore, 1635-1669.
  • Sinha, A.A, Mietzner, T, Lock, C.B., McDevitt, H.O. (1993) Fluorescence-activated cell sorter analysis of peptide-major histocompatibility complex. In: Fluorescence-activated cell sorter analysis of peptide-major histocompatibility complex. Academic Press,, 187-192.
  • Sinha AA. (1990) Molecular Biology of HLA Class ll Antigens. In: Functional Importance of MHC class ll Polymorphism in normal immune responses and autoimmune disease. CRC Press, Inc, 147-168.
  • McDevitt, H.O., Sinha AA. (1990) Allelic Polymorphism of HLA class ll antigens: clues to the moleular basis of autoimmunity. In: Allelic Polymorphism of HLA class ll antigens: clues to the moleular basis of autoimmunity. Academic Press,, 39-52.
  • Diener, E., Fotedar, R., Sinha, A.A. (1990) Regulation of the B cell response: activation and differentiation. In: Regulation of the B cell response: activation and differentiation. Oxford University Press
  • Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Steinman, L, McDevitt, H.O. (1989) HLA-DR and HLA-DQ ALLELES ASSOCIATED WITH PEMPHIGUS VULGARIS. In: HLA-DR and HLA-DQ ALLELES ASSOCIATED WITH PEMPHIGUS VULGARIS. , 465-468.
  • Diener, U., Diener, E., Sinha, A.A, Xie, S., Vergidis, R. (1986) Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers. In: Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers. Elsevier Science Publications, 177-181.

Abstracts:

  • Sinha AA. (2010) Microfixture enabled in-situ imaging manipulation of cell membrane protein. E-Published/ Proceedings of the 5th IEEE International Conference on Nano/Micro Enginereed and Molecular Systems, (Jan)
  • Sinha AA. (2010) Investigations on Biomarkers for Human Lymphoblastoid Cells using atomic force microscopy. E- Published / Proceedings of the th International Conference on Nano/Micro Engineered and Molecular Systems, (Jan)
  • Sinha AA. (2009) Analysis of Keratinocytes stiffness aafter desmosome disruption using Atomic Force Microscopy. E- Published / Proceedings of the 9th IEEE Conference on Nanotechnology,, (Jan)
  • Sinha AA. (2009) Development of cell fixture for in-situ imaging and manipulation of membran protein structure. E- Published / Proceeding of the 9th IEEE Conference on Nanotechnology, (Jan) 397-400
  • Sinha AA. (2007) Response Criteria for Cutaneous SLE in clinical trials. Clin. Exp. Rheuumatol, (Jan) 666-671

Professional Memberships:
  • Nanomedicine Society (2015–present)
  • Alliance for Lupus Research (2008–2012)
  • Arthritis Foundation - Cellular Immunology Study Section (2006–2012)
  • Chicago Dermatological Society (2006–2011)
  • Michigan Dermatology Society (2006–2011)
  • Michigan State Medical Society (2006–2011)
  • Association of Professors of Dermatology (2006–present)
  • American Association for the Advancement of Science (2006–present)
  • International Society of Dermatology (2006–present)
  • Fellow, American Academy of Dermatology (2005–present)
  • Society for Investigative Dermatology (1998–present)
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Presentations:
  • "Clinical Presentation and Diagnosis of Autoimmune Blistering Disease" Annual Meeting of The Association of Medical Laboratory Immunologists (2025)
  • "Non-desmoglein autoantibodies in pemphigus in the context of desmoglein compensation and supercompensation." Scientific Meeting of the International Pemphigus and Pemphigoid Foundation (2024)
  • "Re-thinking smoking as a risk factor for pemphigus" Scientific Meeting of the International Pemphigus and Pemphigoid Foundation (2024)
  • "Healthy individuals genetically at risk for the development of pemphigus vulgaris or alopecia areata exhibit disease like cytokine dysregulation." Scientific Meeting of the International Pemphigus and Pemphigoid Foundation. (2024)
  • "Large scale autoantibody profiling identifies actionable biomarkers linked to multiple disease parameters that can be used in predictive machine learning algorithms." Scientific Meeting of the International Pemphigus and Pemphigoid Foundation. (2024)
  • "Single cell and multiparameter immunome analysis highlights the role of the Th17 pathway in pemphigus." Scientific Meeting of the International Pemphigus and Pemphigoid Foundation. (2024)
  • "Evolving paradigms in the pathogenesis and management of pemphigus." IADR/AADOCR/CADR (2024)
  • "Parallel investigative studies to ARGX 113-1904" ArgenX (2023)
  • "The role of immunosuppressants in the management of autoimmune bullous disease." International Pemphigus and Pemphigoid Foundation Patient Education Conference (virtual) (2023)
  • "Predisposing factors in pemphigus." 5th Scientific meeting of the International Pemphigus and Pemphigoid Foundation (virtual) (2021)
  • "Clinical presentation and diagnosis of autoimmune blistering disorders." EUROIMMUN US Academy Webinar (2021)
  • "Tracking mechanisms of autoimmunity in the skin." NIH T35 Program Lecture Series. University at Buffalo (2021)
  • "Cutaneous manifestations of sexually transmitted infections." Skin Spectrum Summit – the Canadian Conference on Ethnodermatology (virtual meeting). (2020)
  • "Autoimmune disease mechanisms and the future of complex disease management: lessons from pemphigus." Department of Dermatology, Morsani School of Medicine, University of South Florida (2020)
  • "Paradigm disruptions regarding mechanisms and management of Pemphigus." Grand Rounds – Blistering Disease Symposium, Division of Dermatology, Albert Einstein College of Medicine (2020)
  • "Common and interesting general dermatology cases." Course on Clinical Pearls in Dermatology (2020)
  • "Ethnodermatology." Course on Clinical Pearls in Dermatology (2020)
  • "Urticaria: clinical presentation and management." Course on Clinical Pearls in Dermatology (2020)
  • "Psoriasis: clinical presentation and management." Course on Clinical Pearls in Dermatology (2019)
  • "The mystery of self/ non-self discrimination: study of skin autoimmunity reveals paradigm disruptions regarding the mechanisms and management of complex disease." Clinical and Translational Research Colloquium, University at Buffalo (2019)
  • "IVIg therapy in pemphigus." 22th Annual International Pemphigus and Pemphigoid Foundation Patient Conference (2019)
  • "The mystery of self / non-self discrimination: Pemphigus as a model to provide new insights regarding mechanisms and management of autoimmunity." Grand Rounds, Department of Medicine, Loyola University (2019)
  • "Monitoring and targeting autoreactive B cells." Department of Chemistry, University at Buffalo (2019)
  • "Rethinking pemphigus: how new insights are disrupting our understanding of and approach to complex disease." Chicago Dermatology Society Meeting (2019)
  • "Tracking the arc of treatment options in pemphigus: from general to increasingly targeted therapies." Chicago Dermatology Society Meeting (2019)
  • "Autoantibody diversity in pemphigus: implications for disease diagnosis, classification, prognosis and prognosis." 21st Annual International Pemphigus and Pemphigoid Foundation Patient Conference (2018)
  • "Genetic advances in pemphigus." 21st Annual International Pemphigus and Pemphigoid Foundation Patient Conference (2018)
  • "Genetics of bullous pemphigoid." 21st Annual International Pemphigus and Pemphigoid Foundation Patient Conference (2018)
  • "Evolving concepts in the pathogenesis and treatment of pemphigus." Grand Rounds, Department of Dermatology, New York Medical College (2018)
  • "Development of a digital solution to facilitate patient – physician interactions in pemphigus." 2018 Pre- International Investigative Dermatology Meeting – Pemphigus and pemphigoid: a new era of translational and clinical science. (2018)
  • "Genetics in CLE." 4th International Conference on Cutaneous Lupus Erythematosus. (2018)
  • "New disruptions and opportunities in dermatology." Department of Dermatology. University of Wisconsin, Madison (2018)
  • "New paradigms in the pathogenesis and management of pemphigus." Grand Rounds, Department of Dermatology, University of Wisconsin, Madison (2018)
  • "Rethinking pemphigus: new paradigms in pathogenesis and management." Grand Rounds, Division of Dermatology. University of Calgary (2018)
  • "Dermatology 2020" 2018 Annual Skin Spectrum Summit (2018)
  • "Genomic investigation in pemphigus." VIII Congreso Internacional de Dermatologia de la Ciudad de Mexico. (2018)
  • "Probing the scope and specificity of the autoantibody response in pemphigus." VIII Congreso Internacional de Dermatologia de la Ciudad de Mexico. (2018)
  • "New concepts in the pathogenesis and treatment of pemphigus." Annual Meeting of the Hawaii Dermatologic Society (2017)
  • "Translational genomics for cutaneous autoimmunity." 2nd BNMC Translational Genomics and Epigenomics Symposium, Roswell Park Cancer Institute. (2017)
  • "The genetics of Pemphigus." 20th Annual International Pemphigus and Pemphigoid Foundation Patient Conference (2017)
  • "The importance of patients participating in clinical trials." 20th Annual International Pemphigus and Pemphigoid Foundation Patient Conference (2017)
  • "Pemphigus: meeting challenges to disease management with new approaches." 2017 Dermatology Society Annual Meeting (2017)
  • "Pemphigus: new concepts in disease pathogenesis." 2017 Dermatology Society Annual Meeting (2017)
  • "Pemphigus: new paradigms in pathogenesis and treatment." Department of Dermatology, University of Miami (2017)
  • "Non-desmoglein antibodies: what is their diagnostic and pathophysiological value?" 4th Scientific meeting of the International Pemphigus and Pemphigoid Foundation (2017)
  • "Pemphigus: emerging concepts in disease pathogenesis and treatment." Division of Dermatology, University of Kansas Medical Center (2017)
  • "Rationale for using bertulimumabs in a bullous pemphigoid trial." 2017 American Academy of Dermatology Annual Meeting (2017)
  • "Pemphigus: new insights into disease mechanisms and treatment." International Dermatology Exchange Program (2017)
  • "The Future of Complex Disease Management: forging a new interface between biology, medicine and technology to impact clinical decision making." 10th National Pharmaceutical Congress (2016)
  • "Autoimmunity in the skin: systems medicine approach to disease." All India Institute of Medical Sciences (2013)
  • "Cutaneous lupus: clinical features and pathogenesis." Hampton University Skin of Color Research Symposium.; Hampton University; Huscri (2013)
  • "Understanding autoimmunity in the skin: a systems approach to complex dermatologic disease." Clinical and Translational Research Colloquium; University at Buffalo (2013)
  • "The Genetics of Pemphigus" International Symposium in Autoimmune Bullous Disorders; International Investigative DermatologyI; IID (2013)
  • "Diagnosis and genetics of autoimmune bullous disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting.; International Pemphigus and Pemphigoid Foundation (2013)
  • "Novel multiplex auto antigen arrays for biomarker discovery in skin autoimmunityf" Clinical and Translational Research Colloquium; University at Buffalo; University at Buffalo (2013)
  • "Pemphigus: clinical features and pathogenesis of disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting.; International Pemphigus and Pemphigoid Foundation; International Pemphigus and Pemphigoid Foundation (2013)
  • "Probing autoantibody diversity in Pemphigus vulgaris: proteomic strategies" Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center,; Loma Linda University Medical Center; Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center, (2013)
  • "Systems medicine for Dermatology: the new interface between biology, medicine, and technology." Grand Rounds Dept. of Dermatology, University of Southern California; University of Southern California; Dept. of Dermatology, University of Southern California (2013)
  • "Pemphigus and pemhigoid: clinical features and approach to management." Webinar; Nufactor; Nufactor (2013)
  • "Emerging strategies for understanding autoimmunity in the skin: lessons from pemphigus." Grand Rounds, Dept. Surgery, University at Buffalo; University at Buffalo; Dept. of Surgery (2013)
  • "How a better understandig of disease etiology is paving the way to new therapies in Pemphigus" Meeting of the Canadian Pemphigus and Pemphigus Foundation; Sunnybrook Health Sciences; Sunnybrook Health Sciences (2012)
  • "New tools to understand the scope and action of autoantibodies in Pemphigus vulgaris (PV)" Basic Science Seminar Series; Yale University; Dept of Dermatology (2012)
  • "Shifting paradigms in complex cutaneous disease: how systems medicine is creating the new interface between biology, medicine, and technology to imp at clinical decision making" Grand Rounds; Yale University; Dermatology Dept. Yale University (2012)
  • "Investigation of autoimmune blistering disease: from genetics to immune-mediated pathology" Immunology Seminar Series; University of California, Irvine; Immunology (2012)
  • "Autoimmunity and the skin: intergration of biological and clinical profiles to understand disease processes in Pemphigus vulgarism" Immunology Grand Rounds, University at Buffalo; University at Buffalo; Dept. of Immunology (2012)
  • "Genetics of Pemphigus" International Pemphigus and Pemphigoid Foundation 15th Annual Patient - Doctor Meeting; IPPF; International Pemphigus and Pemphigoid Foundation (2012)
  • "Strategies for understanding autoimmunity in the skin." Dept. of Cancer Pathology and Prevention; Roswell Park Cancer Institute; Dept. of Cancer Pathology and Prevention (2012)
  • "Dermatology - Career Paths" Medical Student Forum; University at Buffalo; University at Buffalo, Medical Student Forum (2012)
  • "Skin, aging, and autoimmunity." Women's Health Symposium on Aging and Wellness across the Lifespan; University at Buffalo (2012)
  • "Cutaneous lupus: clinical and etiologic considerations" Hampton University Skin of Color Symposium; Hampton, University (2011)
  • "Autoimmunity of the skin: investigating immune disturbances in Pemhigus vulgaris" Veterans Administration Western NY Healthcare System; Veterans Administration Western NY Healthcare System; Veterans Administration Western NY Healthcare System (2011)
  • "Constructing immunoprofiles to deconstruct disease complexity in pemphigus" Buffalo-Rochester Dermatology Meeting; Buffalo- Rochester Dermatology Society; Buffalo- Rochester Dermatology Society (2011)
  • "Management of Pemphigus and Pemphigoid" Buffalo-Rochester Dermatology Meeting; Buffalo- Rochester Dermatology Society; Buffalo- Rochester Dermatology Society (2011)
  • "Developing disease registry for pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation.; IPPF; International Pemphigus and Pemphigoid Foundation (2011)
  • "Genetic basis of pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation; IPPF; IPPF (2011)
  • "Shifting Paradigms in complex cutaneous disease: harnessing biological and clinical information to impact disease management" ; ; University at Buffalo (2011)
  • "Current Concepts in The Treatment of Blistering Disorders" Grand Rounds; Eastern Virginia Medical School; Department of Dermatology (2011)
  • "Systems Medicine and Dermatology: merging clinical and biological data to develop new tools for disease management" Hampton University Skin of Color Symposium; Hampton University Skin of Color Institute; Hampton University Skin of Color Institute (2011)
  • "Biomarkers and Immunoprofiling in Pemphigus" ; Biogen/IDEC (2010)
  • "Immunoprofiling to unravel disease complexity in pemphigus" Pemphigus and Pemhigoid: From the Bench to the Bedside Meeting; National Institutes of Health (2010)
  • "Systems approach to investigate immune dysregulation in pemphigus vulgaris." Grand Rounds; Wayne State University; Department of Dermatology (2010)
  • "Dermatology: Career Perspectives and Academic Horizons" Internal Medicine Club and Dermatology Interest Group Meeting; Michigan State University (2010)
  • "Systems strategies to study skin autoimmunity" Grand Rounds; University of Florida; Department of Dermatology (2010)
  • "New Concepts and Experimental Stategies to Understand Pemphigus" Symposio Internationale de Dermatologica (2010)
  • "Why Do Patients Flare? How new technologies are helping us to understand disease mechanisms." 12th Annual Meeting of the International Pemphigus and Pemphigoid Foundation (2010)
  • "Genetic Basis of Pemphigus" Symposium on Autoimmune Bullous Disease, 68th Annnual Meeting of the American Academy of Dermatology; American Academy of Dermatology (2010)
  • "Systems Medicine and Dermatology: integrating high throughput genetic, genomic, and proteomic strategies to tackle biological complexity and disease hetergeneity" Grand Rounds; State University of New York at Buffalo; Department of Dermatology (2010)
  • "How New Genetic Technologies Are Changing Clinical Medicine" Rotary Club (2003)
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Service Activities:
  • Insights from You: The Value of Patient Samples on Pemphigus & Pemphigoid Research - Patient Webinar; Invited Speaker (2025)
  • ISID satellite meeting: International Symposium on Autoimmunity Targeting the Skin - Pemphigus, Pemphigoid, and Beyond, Tokyo, Japan; Chair, Immunological Mechanisms of Pemphigus (2023–present)
  • Skin Images Working Group; Advisory Board Member (2023–present)
  • Faculty Senate; Elected Member (2023–present)
  • Derm Club Dermatology Podcast, with Host Hannah Kopelman, Discussion on Autoimmune Blistering Disorders with A. Sinha, MD, PhD.; Invited Guest (2021–present)
  • International Pemphigus and Pemphigoid Foundation, Back to Basics Interactive Webinar Series, Immunosuppressants; Host (2021–present)
  • International Pemphigus and Pemphigoid Foundation; Natural History Study Survey Development Committee Member (2021–present)
  • International Pemphigus and Pemphigoid Foundation, Telephone Town Hall Meeting; Host (2020–present)
  • Panel on Race and Dermatology, Skin Spectrum Summit - the Canadian Conference on Ethnodermatology; Member (2020–present)
  • Society for Investigative Dermatology, Committee on Finance; Member (2019–present)
  • Pre-IID satellite meeting: Pemphigus and Pemphigoid: A New Era of Translational Clinical Science, Orlando, Florida; Chair, Session on Patient Reported Outcomes (2018–present)
  • 4th Scientific Meeting of the International Pemphigus and Pemphigoid Foundation, Lubeck, Germany; Scientific Program Committee Member (2017–present)
  • Podcast, Journal of Drugs and Dermatology, Longitudinal tracking of autoantibody levels in pemphigus and management pearls; Guest (2017–present)
  • Medscape Podcast, A closer look at Pemphigus vulgaris: clinical challenges and emerging treatments; Guest (2017–present)
  • 23rd World Congress of Dermatology, Vancouver, BC, Canada; Chair, Mini-Symposium on Genetics (2015–present)
  • International Pemphigus and Pemphigoid Foundation, Telephone Town Hall Meeting, Causes and consequences of pemphigus; Host (2015–present)
  • Doctor Radio on Sirius XM, Autoimmune Blistering Disorders; Guest (2014–present)
  • Good Morning Connecticut, The symptoms of the autoimmune disease, its causes and how to cope with it. ABC Television, New Haven, CT; Guest (2013–present)
  • Genetics, Genomics, and Bioinformatics Graduate Program Committee, University at Buffalo; Member (2013–present)
  • International Pemphigus and Pemphigoid Foundation, Telephone Town Hall Meeting, Genetic basis of pemphigus; Host (2012–present)
  • Brody Fellowship Awards Selection Committee, University at Buffalo; Member (2012–2017)
  • Frawley Fellowship Awards Selection Committee, University at Buffalo; Member (2012–2017)
  • Department of Dermatology, University at Buffalo; Program Director of Residency Training (2012–2017)
  • Biomedical Informatics Chair Search Committee, University at Buffalo; Member (2012–present)
  • Bioinformatics Faculty and Chair Search Committee, University at Buffalo; Member (2012–present)
  • Faculty Senate, University at Buffalo; Elected Member (2011–2017)
  • UB | MD Marketing Committee, University at Buffalo; Member (2011–2017)
  • Faculty Promotions Committee, University at Buffalo; Member (2011–2017)
  • 14th Annual Patient-Doctor Meeting of the International Pemphigus and Pemphigoid Foundation, Detroit, Michigan; Chair, Organizing Committee (2011–present)
  • Hampton University Skin of Color Research Instititute; Advisory Board (2010–present)
  • Biogen/IDEC; Scientific Advisory Board (2010–present)
  • Foundation for Global Skin Health Strategies; Advisory Board (2009–present)
  • Guest, Today Show, Segment on Genetic Testing; Invited Participant (2008–present)
  • MD-PHD Committee; Board Member (2007–present)
  • Search Committee for Faculty position in Genetics; Committee Member (2007–present)
  • Guest, "Please Explain - Hair" National Public Radio (WNYC); Invited Participant (2005–present)
  • American Vitiligo Research Foundation; Medical Advisory Board Member (2004–2014)
  • International Pemphigus and Pemphigoid Foundation; Medical Advisory Board Member (2004–present)
  • Guest column, "Serious Skin Disorders Often Go Undetected" Bottom Line/Health, Standford CT; Invited Participant (2003)
  • Webcast on Cutaneous Lupus Erythematosus; Invited Participant (2002)
  • Guest expert of hair loss webcast. Healthology, Inc; Invited Participant (2001)
  • Guest on ‘The Bald Truth" radio show (WOR), Spencer Kobren, host, NY, NY; Invited Participant (2000–present)
  • Guest expert on the genetics of hair loss.; Invited Participant (2000–present)
  • PhD Thesis Advisory Committee; Advisor
  • MSc Thesis Advisory Committee; Advisor
  • The Open Autoimmunity Journal; Autoimmune Diseases; British Journal of Dermatology; Experimental Dermatology; Journal of Nanoscience Letters; World Journal of Dermatology; Journal of Dermatologic Research and Therapy; Frontiers in Medicine, Dermatology Section, Associate Editor; Journal of Ethnodermatology, Medical Editor;; Membership, Scientific Journal Editorial Boards
  • Acta Dermato-venerologica; Acta Dermatovenerologica Croatica; American Journal of Dermatology; American Journal of Clinical Dermatology; Angiology; Apoptosis; Archives of Dermatologic Research; Arthritis and Rheumatism; Arthritis Research & Therapy; Autoimmunity; BioMed Central Cancer; BioMed Central Dermatology; BioMed Central Medicinal Genomics; BioMed Central Research Notes; BioMed Research International; BioMedicine; British Journal of Clinical Pharmacology; Cell Biology and Toxicology; Cell Biochemistry and Function; Cellular and Molecular Life Sciences; Clinical, Cosmetic and Investigational Dermatology; Clinical Interventions in Aging; Current Aging Science; Current Medicinal Chemistry; Cytometry; Dermatology; Dermatology Research and Practice; Dermatology and Therapy; Disease Markers; Emerging Infectious Diseases; European Journal of Dermatology; European Journal of Inflammation; Evidence-Based Complementary and Alternative Medicine; Experimental Dermatology; Expert Opinion on Orphan Drugs; Expert Opinion on Therapeutic Targets; Expert Review of Clinical Immunology; Frontiers in Immunology; Frontiers in Medicine; Genes and Immunity; Genomics; Hair: Therapy & Transplantation; Human Immunology; Immunobiology; Immunological Investigations; Immunopharmacology and Immunotoxicology; International Journal of Allergy Medications; International Journal of Dermatology; International Journal of Immunogenetics; International Journal of Immunopathology and Pharmacology; Journal of Autoimmunity; Journal of the American Academy of Dermatology; Journal of Biological Chemistry; Journal of Clinical Immunology; Journal of Clinical Laboratory Analysis; Journal of Clinical Oncology; Journal of Cutaneous Medicine and Surgery; Journal of Dermatological Science; Journal of Dermatology; Journal of Dermatology and Clinical Research; Journal of Drugs and Dermatology; Journal of Gateroenterology and Hepatobilliary Disorders; Journal of Immunology; Journal of International Medical Research; Journal of Investigative Dermatology; Journal of Medical Case Reports; Journal of Molecular Cell Biology; Journal of the National Medical Association; Journal of the São Paulo Institute of Tropical Medicine; Molecular Medicine Reports; Nanomedicine: Nanotechnology, Biology, and Medicine; Nature Reviews Disease Primers; Nature Communications; North American Journal of Medical Sciences; Oncotarget; Peptides; PLoS Genetics; Proceedings of the National Academy of Science; Qatar Medical Journal; Revista do Instituto de Medicina Tropical de Sao Paulo; Science Translational Medicine; Self/Nonself;; Reviewer (ad hoc), Scientific Journals
  • 2006 - 2012 Arthritis Foundation – Cellular Immunology Study Section 2008 - 2012 Alliance for Lupus Research 2010 NIH ZRG1 Moss G02 2012 NIH ZRG1 Moss ODCS 2012 University City Science Center (Science Center) QED program 2013 PSI (Physician Services Incorporated) Foundation 2013 NIH/NIAID ACE, Basic Research Program 2013 NIH/NIAID ACE, Clinical Research Program 2016 NIH/NIAMS P50 Centers of Research Translation (CORT) 2016/08 ZAR1 KM 2016 – present American Skin Association Research Awards Program 2018 NIH/NIAID ACE, Basic Research Program 2018 NIH/NIAID ACE, Clinical Research Program 2019/01 ZAI1 ZL-I (J1) 2019 – present NIH/NIAID Autoimmune Data Safety and Monitoring Board (DSMB) 2020 – present Wellcome Trust 2021 NIAMS Skin Biology and Diseases Resource-based Centers (P30) 2021 Patient Centered Outcomes Research Institute (PCORI) 2021 NIH/NIAMS P50 Centers of Research Translation (CORT) 2023 NIAMS R01/R21 Special Emphasis Panel; Scientific Research Study Section Membership/Grant Review Panel

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Contact Information

6078 Clinical and Translational Research Center
875 Ellicott, Street
Buffalo, New York 14203
Phone: 716-842-2116
aasinha@buffalo.edu
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This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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