Areas of Research
Brahm Segal, MD, conducts research at Roswell Park Comprehensive Cancer Center that has broad relevance for diseases associated with inflammation.
Faculty in our division investigate the pathogenesis, treatment and prevention of an array of infectious diseases—translational research with the potential for broad public application.
The physician-scientists on our clinical service generate many of the questions and ideas that drive our translational research program. We frequently isolate bacterial strains from our patients for use in our investigations.
We pursue research in the following areas:
Nikolaos Almyroudis, MD
- Epidemiology of vancomycin resistant Enterococcus infections in patients with malignancies
- Opportunistic infections in the immunocompromised host
- Resistant bacteria in patients with malignancies
Charles Berenson, MD
- Microbiome restoration in Clostridioides difficile colitis
John Crane, MD, PhD
- Intestinal pathogenic Escherichia coli pathogenesis : Diarrhea-producing E. coli
- Mechanism of Emergence of Antibiotic Resistance : Role of SOS Response in Antibiotic Resistance
- Microbial pathogenesis
- Role of nitric oxide in host defense in the intestinal tract : Role of nitric oxide in host defense in intestine
- Role of zinc in intestinal infection
Alan Lesse, MD
- Bioinformatics
- Infectious Diseases
Thomas Russo, MD
- Acinetobacter baumannii pathogenesis
- Drug development : A. baumannii
- Extraintestinal pathogenic Escherichia coli pathogenesis : pathogenesis vaccine development
- Host-pathogen interactions : Understanding mechanisms by which extraintestinal patghogenic E. coli modify host defenses
- Klebsiella pneumoniae pathogenesis : drug target identification pathogenesis biofilms
- Microbial pathogenesis : Understanding the mechanisms by which extraintestinal pathogenic E. coli, Acinetobacter, and Klebsiella cause disease
- Vaccine development : Extraintestinal pathogenic E. coli, Klebsiella pneumoniae, and Acinetobacter