Areas of Research

Segal, Brahm.

Brahm Segal, MD, conducts research at Roswell Park Comprehensive Cancer Center that has broad relevance for diseases associated with inflammation.

Faculty in our division investigate the pathogenesis, treatment and prevention of an array of infectious diseases—translational research with the potential for broad public application.

The physician-scientists on our clinical service generate many of the questions and ideas that drive our translational research program. We frequently isolate bacterial strains from our patients for use in our investigations.

We pursue research in the following areas:

Nikolaos Almyroudis, MD

  • Epidemiology of vancomycin resistant Enterococcus infections in patients with malignancies
  • Opportunistic infections in the immunocompromised host
  • Resistant bacteria in patients with malignancies

Charles Berenson, MD

  • Haemophilus influenzae pathogenesis
  • Immunoregulatory roles of macrophage ganglioside
  • Role of alveolar macrophages in the pathogenesis of respiratory tract infections

John Crane, MD, PhD

  • Intestinal pathogenic Escherichia coli pathogenesis
  • Microbial pathogenesis
  • Role of nitric oxide in host defense in the intestinal tract
  • Role of zinc in intestinal infection

Timothy Murphy, MD

  • Bacterial infection in chronic obstructive pulmonary disease (COPD)
  • Haemophilus influenzae pathogenesis
  • Microbial pathogenesis within the respiratory tract
  • Moraxella catarrhalis pathogenesis
  • Vaccine development

G. Iyer Parameswaran, MD

  • Bacterial infection in chronic obstructive pulmonary disease (COPD)

Thomas Russo, MD

  • Acinetobacter baumannii pathogenesis
  • Drug development
  • Extraintestinal pathogenic Escherichia coli pathogenesis
  • Host-pathogen interactions
  • Identification of antimicrobial targets
  • Klebsiella pneumoniae pathogenesis
  • Microbial pathogenesis
  • Pathogenesis of urinary tract infection
  • Vaccine development

Brahm Segal, MD

  • Clinical studies of infectious diseases in patients with cancer