Areas of Research

Segal, Brahm.

Brahm Segal, MD, conducts research at Roswell Park Comprehensive Cancer Center that has broad relevance for diseases associated with inflammation.

Faculty in our division investigate the pathogenesis, treatment and prevention of an array of infectious diseases—translational research with the potential for broad public application.

The physician-scientists on our clinical service generate many of the questions and ideas that drive our translational research program. We frequently isolate bacterial strains from our patients for use in our investigations.

We pursue research in the following areas:

Nikolaos Almyroudis, MD

  • Epidemiology of vancomycin resistant Enterococcus infections in patients with malignancies
  • Opportunistic infections in the immunocompromised host
  • Resistant bacteria in patients with malignancies

John Crane, MD, PhD

  • Intestinal pathogenic Escherichia coli pathogenesis
  • Mechanism of Emergence of Antibiotic Resistance
  • Microbial pathogenesis
  • Role of nitric oxide in host defense in the intestinal tract
  • Role of zinc in intestinal infection

Alan Lesse, MD

  • Bioinformatics
  • Infectious Diseases

Timothy Murphy, MD

  • Vaccine development

Thomas Russo, MD

  • Acinetobacter baumannii pathogenesis
  • Drug development
  • Extraintestinal pathogenic Escherichia coli pathogenesis
  • Host-pathogen interactions
  • Klebsiella pneumoniae pathogenesis
  • Microbial pathogenesis
  • Vaccine development

Brahm Segal, MD

  • Innate Immunity