8/28/18
Periprosthetic joint infection (PJI) is a devastating outcome of total joint arthroplasty that gives rise to increased patient morbidity and rising costs to the health care system. PJI can develop clinically, even in the presence of antibiotic treatment, and antibiotic resistance of bacterial biofilms limits the effectiveness of available treatment methods for implant-associated orthopaedic infections. The current treatment for refractory joint infections involves removal of the implant, debridement of the tissue, immobilization of the patient and prolonged antibiotic therapy.