Dubocovich: Novel Melatonin Receptor Molecules

Newly discovered molecules can modulate circadian rhythms by binding to a melatonin receptor in the biological clock, according to new research in mice. The research could facilitate the development of targeted therapies that can either mimic or counteract the actions of melatonin. “This discovery allows us to now focus on the development of unique new molecules to generate a response that will help bring sleep patterns and other biological rhythms in line with environmental light and dark cycles, providing the sense of well-being that is only experienced when such rhythms are in sync,” says Margarita L. Dubocovich, PhD, SUNY Distinguished Professor of pharmacology and toxicology.