Core Facilities

Our school’s shared core instrumentation and transgenic animal facilities support research by UB faculty and investigators at our affiliated institutions. These facilities not only house state-of-the-art equipment but in many cases also provide data analysis, training and grant writing consultation.

  • Confocal Microscope and Flow Cytometry Facility
    The Confocal Microscope and Flow Cytometry Facility (CMFCF) is a Dept. Pathology and Anatomical Sciences (PAS) service center serving the researchers in the Jacobs School of Medicine and Biomedical Sciences as well as the scientists located on the South and North Campus’s at the University at Buffalo.  We are part of the Health Sciences Collaborative Core Facilities and work closely with other PAS cores as well as the core facilities in the School of Dental Medicine to provide comprehensive and integrative services to solve the imaging and cytometry challenges presented by cutting-edge research programs.  The imaging and cytometry instrumentation installed in the new Jacobs School of Medicine site are the latest, state of art flow cytometers and optical microscopes.
  • Electron Microscopy Core Lab
    Enables researchers to obtain transmission electron microscope images of materials, polymers and biological samples; consults with investigators and assists with equipment operation.
  • Histology Core
    Performs all procedures related to tissue preservation and histological analysis, including training on cryostat use and other protocols.
  • Induced Pluripotent Stem Cell Generation
    Helps investigators generate induced pluripotent stem cells from human skin fibroblasts using lentiviral vectors.
  • Institute for Healthcare Informatics
    Equips researchers with a HIPAA-compliant computing environment, healthcare datasets and analytic and security consulting.
  • Molecular Interactions
    Offers powerful, analytical instrumentation used to study macromolecular interactions.
  • Next-Generation Sequencing and Expression
    Offers high-throughput, next-generation sequencing and gene-expression analysis services, including 3’-expression, miRNA, exon and gene arrays.
  • Protein Expression and Crystallization
    Offers instrumentation and the technical expertise required to express and purify milligram quantities of soluble and membrane proteins for biophysical and structural characterization.
  • Proteomics/Mass Spectrometry
    Identifies proteins in cell or tissue extracts using several different liquid chromotography/mass spectrometry based approaches.
  • Stem Cell Culture, Banking and Training
    Maintains and banks stem cells, and provides stem cells and training to interested researchers.
  • Stem Cell Engraftment and In Vivo Analysis
    Engrafts stem cells into mice and other model systems; quantifies cell engraftment, migration and differentiation, and analyzes the behavior consequences of neural engraftment.
  • Stem Cell Sequencing/Epigenomics Analysis
    Characterizes and identifies epigenetic and transcription signatures of stem cells and their derived progeny using Next-Gen sequencing.
  • Toxicology Research Center
    Analyzes xenobiotics and other metabolites, and supports OSHA-sponsored educational activities.