Wang R,Hausknecht K,Shen RY,Haj-Dahmane S. Potentiation of Glutamatergic Synaptic Transmission Onto Dorsal Raphe Serotonergic Neurons in the Valproic Acid Model of Autism. Frontiers in Pharmacology. 2018; 9
David Dietz, PhD, investigates cellular changes by which drugs “hijack” the central nervous system’s reward circuitry, causing addiction. He studies how differences in individuals’ molecular and behavioral plasticity mediate susceptibility to drug abuse and relapse.
Suzanne Laychock, PhD, is investigating the cellular mechanisms regulating insulin secretion in pancreatic cells. Her group has used pancreatic cells in primary culture to develop in vitro systems that mimic aspects of Type 1 and Type 2 diabetes.
Margarita L. Dubocovich, PhD, works to elucidate melatonin’s mechanism of action and role in modulating circadian rhythms. Her lab develops novel molecules targeting melatonin receptors to treat depression, sleep disorders and cardiovascular disease.
Fraser J. Sim, PhD, studies the molecular mechanisms controlling stem and progenitor cell fate in the human brain. His lab seeks to develop novel drug- and cell-based therapies for repair and regeneration in demyelinating diseases, such as multiple sclerosis.
James R. Olson, PhD, has traveled to Egypt to work with cotton laborers exposed to pesticides. His research links genetics, an individual’s degree of exposure to pesticides and effects on health, seeking to improve workplace and environmental health worldwide.
Our school’s shared core instrumentation and transgenic animal facilities support research by UB faculty and investigators at our affiliated institutions. These facilities not only house state-of-the-art equipment but in many cases also provide data analysis, training and grant writing consultation.
Provides state-of-art bioinformatics assistance for the design, analysis, and interpretation of genomics, proteomics, and other high-resolution, high-throughput based studies for better understanding of cancer biology.
Our instrument laboratory provides training and consultation services for researchers whose work involves flow cytometry, confocal microscopy and gel-documentation. We work closely with other core facilities to provide comprehensive and integrative services to solve the imaging and cytometry challenges presented by cutting-edge research programs.