An integrated academic home for UB’s outstanding clinical
research and translational science, and the hub of the Buffalo
Translational Consortium. The CTRC provides innovative research
tools, support, training, resources and coordination.
Provides state-of-art bioinformatics assistance for the design, analysis, and interpretation of genomics, proteomics, and other high-resolution, high-throughput based studies for better understanding of cancer biology.
Our school’s shared core instrumentation and transgenic
animal facilities support research by UB faculty and investigators
at our affiliated
institutions. These facilities not only house state-of-the-art
equipment but in many cases also provide data analysis, training
and grant writing consultation.
J. Sim, PhD, studies the molecular mechanisms controlling stem
and progenitor cell fate in the human brain. His lab seeks to
develop novel drug- and cell-based therapies for repair and
regeneration in demyelinating diseases, such as multiple
Dietz, PhD, investigates cellular changes by which drugs
“hijack” the central nervous system’s reward
circuitry, causing addiction. He studies how differences in
individuals’ molecular and behavioral plasticity mediate
susceptibility to drug abuse and relapse.
Rajnarayanan, PhD, studies interactomes of the human estrogen
receptor, which is expressed in 70 percent of breast cancers. His
lab seeks to design molecules to improve the effects of
tamoxifen, a drug commonly prescribed to treat breast cancer.
R. Olson, PhD, has traveled to Egypt to work with cotton
laborers exposed to pesticides. His research links genetics, an
individual’s degree of exposure to pesticides and effects on
health, seeking to improve workplace and environmental health
Laychock, PhD, is investigating the cellular mechanisms
regulating insulin secretion in pancreatic cells. Her group has
used pancreatic cells in primary culture to develop in vitro
systems that mimic aspects of Type 1 and Type 2 diabetes.
L. Dubocovich, PhD, works to elucidate melatonin’s
mechanism of action and role in modulating circadian rhythms. Her
lab develops novel molecules targeting melatonin receptors to treat
depression, sleep disorders and cardiovascular disease.