Bianca Weinstock-Guttman MD

Bianca Weinstock-Guttman

Bianca Weinstock-Guttman


Department of Neurology

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Immunosuppressive Pharmacotherapy; Multiple Sclerosis; Neuroimmunology; Neurology

Contact Information
Dept. of Neurology
Jacobs School of Medicine and Biomedical Sciences
1010 Main St., 2nd floor
Buffalo, New York 14202
Phone: (716) 829-5055
Fax: (716) 829-4411

Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD

Professional Summary:

My clinical practice is devoted to the comprehensive care of adults and children living with multiple sclerosis (MS) and other demyelinating disorders. I direct the Jacobs Multiple Sclerosis Center for Treatment and Research at UBMD Neurology; our clinic offers state-of-the-art diagnostic and therapeutic interventions for MS patients and for patients with other autoimmune diseases affecting the central nervous system. We provide a full spectrum of support services to patients including, but not limited to neurocognitive assessment, physical and occupational therapy and social work services that help both patients and families. Additionally, I serve on hospital inpatient service several times a year.

I also direct the Pediatric Multiple Sclerosis Center of Buffalo, one of the initial six centers of excellence established by the National Multiple Sclerosis Society. In addition, I serve as executive director of the New York State Multiple Sclerosis Consortium (NYSMSC), one of the largest MS registries in the nation. In support of my patients, I speak to patient and family groups about our MS research and emerging therapies. My team members and I offer special patient programs where we discuss topics such as MS therapies as well as the importance of exercise, nutrition, healthy lifestyle and more specific issues such as reproduction, osteoporosis and aging.

My research interests are aimed at better understanding the heterogeneity of MS, identifying predictors of disease progression with a primary focus on genetic and environmental interactions and influences on MS disease phenotype. I am also interested in response to therapy, e.g., influences on physical and neurocognitive status. Pediatric MS, an insufficiently explored subject, is an important area of my clinical and research interests. More recent foci of my research include understanding the cholesterol link to MS and its influence on the pathobiology of MS, bone health and exercise programs for patients with MS and aging: patient characteristics and biomarkers associated with, and predictive of improved quality of life and/or MS disease stabilization in MS aging.

I lecture students and residents on a regular basis. I also mentor five to seven pre-residency candidates and fourth-year medical students per year in clinical rotations and in research project design and implementation.

Education and Training:

  • Fellowship, Mellen Center for MS Treatment and Research, Cleveland Clinic Foundation (1996)
  • MD, Neurology, Sapir Medical Center, Meir General Hospital, Tel Aviv University (1992)
  • Internship, Carmel Hospital (1986)
  • MD, Institute of Medicine and Pharmacy, University of Bucharest (1983)


  • Distinguished Professor, Neurology, State University of New York (2021-present)
  • Executive Director, Ny State MS Consortium (2010-present)
  • Director, Pediatric MS Center (2006-present)
  • Professor of Neurology, Neurology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011-present)
  • Director, Jacobs MS Center for Treatment and Research (2002-present)
  • Associate Professor, Neurology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2005–2011)
  • Assistant Professor of Neurology, Neurology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998–2004)
  • Clinical Associate, Neuroimmunology and Neurology, Mellen Center for MS Treatment and Research, Cleveland Clinic Foundation (1997–1998)

Awards and Honors:

  • Stockton Kimball Award (2020)
  • Impact Award for Research, Patient care and Advocacy (2018)
  • Sustained Achievement Award (2013)
  • Stephen H. Kelley Award from the National M.S. Society (2011)
  • Neurology Resident Teacher of the year (2007)
  • "Business First's Healthcare Top 50 Physicians" (2006)
  • Humanitarian of the Year (1995)

Research Expertise:

  • Autoimmune Diseases
  • Multiple sclerosis
  • Neuromyelitis Optica Spectrum Disorder

Research Centers:

  • Jacobs Neurological Institute

UB 2020 Strategic Strengths:

  • Health and Wellness Across the Lifespan

Grants and Sponsored Research:

  • January 2020–December 2026
    A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis, BEAT-MS (Protocol ITN077AI)
    National Institute of Allergy & Infectious Diseases (NIAID), Division of Allergy, Immunology &Transplantation (DAIT) via a subaward
    Role: Principal Investigator
  • June 2020–December 2025
    A Multicenter, Longitudinal, Open-Label, Single-Arm Study Describing Cognitive Processing Speed Changes in Relapsing Multiple Sclerosis Subjects Treated with Ozanimod (RPC-1063)
    Celgene International
    Role: Principal Investigator
  • June 2019–December 2024
    Feasibility of the Multiple Sclerosis Performance Test for assessment of functional performance measures in patients with Multiple Sclerosis (US-MSG-18-11424)
    Role: Principal Investigator
  • March 2021–August 2022
    A study to evaluate the natural history of secondary progressive multiple sclerosis in never-treated or late starters compared to early treated patients.
    Role: Principal Investigator
  • December 2019–December 2021
    Evaluation of patient-reported outcomes associated with use of dimethyl fumarate in a real-world setting.
    Role: Principal Investigator
  • June 2018–August 2021
    A prospective study to validate the Expanded Timed Get Up and Go (ETGUG) in multiple sclerosis patients with varying levels of disability.
    Role: Principal Investigator
  • June 2017–June 2020
    The effects of working memory training on brain function, structure, and cognition in MS
    National Multiple Sclerosis Society
    Role: Co-Investigator
  • September 2014–August 2015
    Does working memory training improve brain function and cognition in MS?
    National Multiple Sclerosis Society
    Role: Co-Investigator
  • January 2006–December 2010
    Application for a pediatric multiple sclerosis center.
    National Multiple Sclerosis Society
    Role: Principal Investigator

Journal Articles: