University at Buffalo researchers — with Harvard colleagues — have discovered a region of the brain responsible for causing deep sleep. “We are at a truly transformative point in neuroscience … We can now answer fundamental questions of brain function, which have traditionally been beyond our reach,” says co-author Caroline E. Bass, PhD, assistant professor of pharmacology and toxicology.
Fraser J. Sim, PhD, assistant professor of pharmacology and toxicology, collaborated on research that generated induced pluripotent stem cells lines from skin samples of multiple sclerosis patients for the first time.
Fraser J. Sim, PhD, assistant professor of pharmacology and toxicology, and his team have identified SOX10 as the single transcription factor that initiates the critical myelination process in the brain.
A study led by Jun-Xu Li, MD, PhD, assistant professor of pharmacology and toxicology, shows that the newly developed RO5263397 compound severely blunts a host of cocaine addiction behaviors, including relapse behavior, in rats.
Caroline E. Bass, PhD, assistant professor of pharmacology and toxicology, is first author on a study that successfully stopped rats from binge drinking behaviors by using light to stimulate specific neurons and release dopamine.
A Circulation study by University at Buffalo and Yale researchers found that MIF20 significantly reduces the amount of heart muscle damaged by myocardial infarction.