PhD Publications
We’re proud of our trainees’ research efforts and publications. Doctoral student Ashley N. White has co-authored work published in journals including Pathogens, Infection and Immunity, and PLOS Pathogens.
Our doctoral students successfully publish their research in well-respected, peer-reviewed journals. These include Molecular Microbiology, Virology and PloS One.
2018
| Student | Title | Faculty Mentor |
|---|---|---|
| Michaelle Chojnacki | The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon. | Thomas Melendy, PhD |
| Michaelle Chojnacki | The HPV E2 Transcriptional Transactivation Protein Stimulates Cellular DNA Polymerase Epsilon | Thomas Melendy, PhD |
| Mary Gallo | Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease. | Timothy F. Murphy, MD |
| Richard Jin | Therapeutic Administration of IL-10 and Amphiregulin Alleviates Chronic Skeletal Muscle Inflammation and Damage Induced by Infection | Elizabeth Wohlfert, PhD |
| Nicole McAdams Rachel Simpson | MRB7260 is essential for productive protein-RNA interactions within the RNA Editing Substrate Binding Complex during trypanosome RNA editing. | Laurie K. Read, PhD |
| Khan Umaer | Rab11 mediates selective recycling and endocytic trafficking in Trypanosoma brucei. | James D. Bangs, PhD |
2017
| Student | Title | Faculty Mentor |
|---|---|---|
| Christian Ahearn Mary Gallo | Insights on persistent airway infection by non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease. | Timothy F. Murphy, MD |
| Richard Jin | Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection. | Elizabeth Wohlfert, PhD |
| Lucie Kafková | The major protein arginine methyltransferase in Trypanosoma brucei functions as an enzyme-prozyme complex. | Laurie K. Read, PhD |
| Dorothy-Anyango Kamina | Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP). | Noreen Williams, PhD |
| Dorothy-Anyango Kamina | Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target. | Noreen Williams, PhD |
| Khan Umaer Emilia Kruzel | The role of the PI(3,5)P2 kinase TbFab1 in endo/lysosomal trafficking in Trypanosoma brucei. | James D. Bangs, PhD |
| Mary Gallo | Immunoglobulin A Protease Variants Facilitate Intracellular Survival in Epithelial Cells By Nontypeable Haemophilus influenzae That Persist in the Human Respiratory Tract in Chronic Obstructive Pulmonary Disease | Timothy F. Murphy, MD |
| Dorothy-Anayango Kamina Daniel Jaremko | Essential assembly factor Rpf2 forms novel interactions with the 5S RNP in Trypanosoma brucei. | Noreen Williams, PhD |
| Rachel Simpson | Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization. | Laurie K. Read, PhD |
2015
| Student | Title | Faculty Mentor |
|---|---|---|
| Priyanka Saminathan | The Membrane Proximal External Regions of gp41 From HIV-1 Strains HXB2 and JRFL Have Different Sensitivities to Alanine Mutation (Biochemistry) | Amy Jacobs, PhD |
| Virginia Havel Glazier Jan Naseer Kaur | Puf4 Regulates Both Splicing and Decay of the mRNA Encoding the Unfolded Protein Response Transcription Factor, HXL1, in Cryptococcus neoformans (Eukaryotic Cell) | John C. Panepinto, PhD |
2014
| Student | Title | Faculty Mentor |
|---|---|---|
| Christopher J. Greene John C. Hu | Intradermal Administration of the Type II Heat-Labile Enterotoxins LT-IIb and LT-IIc of Enterotoxigenic Escherichia coli Enhances Humoral and CD8+ T Cell Immunity to a Co-Administered Antigen (PLoS One) | Terry D. Connell, PhD |
| Dithi Banerjee | Inhibition of Nucleotide Biosynthesis Potentiates the Antifungal Activity of Amphotericin B (PLoS One) | John C. Panepinto, PhD |
| Amanda L. Bloom | RNA Biology and the Adaptation of Cryptococcus neoformans to Stress and Host-Temperature [invited review, WIRES RNA] | John C. Panepinto, PhD |
| Martin Ciganda Khan Umaer | Ribosome Biogenesis in African Trypanosomes Requires Conserved and Trypanosome-Specific Factors (Eukaryotic Cell) | Noreen Williams, PhD |
| Eukaryotic rRNA Processing (Encyclopedia of Cell Biology) |
2013
| Student | Title | Faculty Mentor |
|---|---|---|
| Michelle R. Simpson-Abelson | Human Ovarian Tumor Ascites Fluids Rapidly and Reversibly Inhibit T Cell Receptor-Induced NF-κB and NFAT Signaling in Tumor-Associated T Cells (Cancer Immunity) | Richard B. Bankert, PhD |
| Katie Edwards | Characterization of a Trifunctional Glucosyltransferase Essential for Moraxella catarrhalis Lipooligosaccharide Assembly (Glycobiology) | Anthony A. Campagnari, PhD |
| Hesham Nawar | Ganglioside-Binding Specificities of E. coli Enterotoxin LT-IIc: Importance of Long Chain Fatty Acyl Ceramide (Glycobiology) | Terry D. Connell, PhD |
| Christopher J. Greene John C. Hu | LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity (PLoS One) | Terry D. Connell, PhD |
| Hyunah Yi | Significant Differences in Cell-Cell Fusion and Viral Entry Between Strains Revealed by Scanning Mutagenesis of the C-Heptad Repeat of HIV gp41 (Biochemistry) | Amy Jacobs, PhD |
| Michaelle Chojnacki | Replicative Helicases as the Central Organizing Motor Proteins in the Molecular Machines of the Elongating Eukaryotic Replication Fork [book chapter in The Mechanisms of DNA Replication (InTech)] | Thomas Melendy, PhD |
| Virginia Havel Glazier | The ER Stress Response and Host Temperature Adaptation in the Human Fungal Pathogen Cryptococcus neoformans [invited review, Virulence] | John C. Panepinto, PhD |
| Amanda L. Bloom Virginia Havel Glazier | Uncoupling of mRNA Synthesis and Degradation Impairs Adaptation to Host-Temperature in Cryptococcus neoformans (Molecular Microbiology) | John C. Panepinto, PhD |
| Lucie Kafkova | A Core MRB1 Complex Component is Indispensable for RNA Editing in Insect and Human Infective Stages of Trypanosoma brucei (PLoS One) | Laurie K. Read, PhD |
| Martin Ciganda Lei Wang | Association of a Novel Pre-Ribosomal Complex in T. brucei Determined by Fluorescence Resonance Energy Transfer (Eukaryotic Cell) | Noreen Williams, PhD |
| Defining the RNA-Protein Interactions in the Trypanosome Preribosomal Complex (Eukaryotic Cell) | ||
| Paul Gulde | Three Distinct Isoforms of ATP Synthase Subunit c are Expressed in T. brucei and Assembled Into the Mitochondrial ATP Synthase Complex (PLoS One) | Noreen Williams, PhD |
| Martin Ciganda | Ribosome Biogenesis Requires a Highly Diverged XRN Family 5’->3’ Exoribonuclease for rRNA Processing in Trypanosoma brucei (RNA) | Noreen Williams, PhD |
2012
| Student | Title | Faculty Mentor |
|---|---|---|
| Kari Brossard | The Acinetobacter baumannii Biofilm-Associated Protein (Bap) Plays a Role in Adherence to Human Epithelial Cells (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Kristin (Furano) Picardo | Identification of a Hemin Utilization Protein of Moraxella catarrhalis (HumA) (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Hesham Nawar | Crystal Structures of Mutant Forms of Escherichia coli Heat-Labile Enterotoxin B Pentamer (Acta Crystallographica Section D) | Terry D. Connell, PhD |
| Hyunah Yi | Inhibition of HIV Entry by Extracellular Glucuronoxylomannan of Cryptococcus neoformans (Microbial Pathogenesis) | Amy Jacobs, PhD |
| Jan Naseer Kaur | Hydroxyurea Enhances Post-Fusion Hyphal Extension in Cryptococcus neoformans var. grubii (Mycopathologia) | John C. Panepinto, PhD |
Bardees Foda | Multifunctional G-Rich and RRM-Containing Domains of TbRGG2 Perform Separate Yet Essential Functions in Trypanosome RNA Editing (Eukaryotic Cell) | Laurie K. Read, PhD |
| Brandon Feinen | Contrasting Roles of IL-22 and IL-17 in Murine Genital Tract Infection by Neisseria gonorrhoeae (Frontiers in Immunology) | Michael W. Russell, PhD |
| Martin Ciganda | Characterization of a Novel Association Between Two Trypanosome-Specific Proteins and 5S rRNA (PLoS One) | Noreen Williams, PhD |
| Martin Ciganda Kristina Hellman Kimberly Prohaska | A Novel Association Between Two Trypanosome-Specific Factors and the Conserved L5-5S rRNA Complex (PLoS One) | Noreen Williams, PhD |
2011
| Student | Title | Faculty Mentor |
|---|---|---|
| Jeremiah Davie | Comparative Analysis and Supragenome Modeling of 12 Moraxella catarrhalis Clinical Isolates (BMC Genomics, Jan. 26, 2011) | Anthony A. Campagnari, PhD |
| Kristin (Furano) Picardo | Identification of a Hemin Utilization Protein of Moraxella catarrhalis (HumA) (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Chang Hoon Lee | In Vivo Immunomodulatory Mechanisms of a Novel Mucosal Adjuvant Derived From a Type II Heat-Labile Enterotoxin (LT-IIa) (Journal of Leukocyte Biology) | Terry D. Connell, PhD |
| Benjamin Briggs | Tick-Borne Encephalitis Virus, Kazakhstan (Emerging Infectious Diseases) | John Hay, PhD |
| Hyunah Yi | Permanent Inhibition of Viral Entry by Covalent Entrapment of HIV gp41 on the Virus Surface (Biochemistry) | Amy Jacobs, PhD |
| Virginia Havel Glazier | Ccr4 Promotes Resolution of the ER Stress Response During Host Temperature Adaptation in Cryptococcus neoformans (Eukaryotic Cell) | John C. Panepinto, PhD |
| Brandon Feinen | New Concepts in Immunity to Neisseria gonorrhoeae: Innate Responses and Suppression of Adaptive Immunity Favor the Pathogen, Not the Host (Frontiers in Microbiology) | Michael W. Russell, PhD |
| Martin Ciganda | Eukaryotic 5S rRNA Biogenesis (Wiley Interdisciplinary Reviews: RNA) | Noreen Williams, PhD |
2010
| Student | Title | Faculty Mentor |
|---|---|---|
| Thomas Loehfelm | Identification and Characterization of a Glycosyltransferase Involved in Acinetobacter baumannii Lipopolysaccharide Core Biosynthesis (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Kristin (Furano) Picardo | Identification of a Hemin Utilization Protein of Moraxella catarrhalis (HumA) (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Hesham Nawar | Mammalian Cell Ganglioside-Binding Specificities of E. coli Enterotoxins LT-IIb and Variant LT-IIb(T13I) (Glycobiology) | Terry D. Connell, PhD |
| Binding to Gangliosides Containing N-acetylneuraminic Acid is Sufficient to Mediate the Immunomodulatory Properties of the Non-Toxic Mucosal Adjuvant LT-IIb(T13I) (Clinical and Vaccine Immunology) | ||
| Jonathan Burgos | Expression of BfrH, a Putative Siderophore Receptor of Bordetella bronchiseptica, is Regulated by Iron, Fur1 and the Extracellular Function Sigma Factor EcfI (Infection and Immunity) | Terry D. Connell, PhD |
| Christopher J. Greene Chang Hoon Lee Hesham Nawar | Enhanced Antigen Uptake by Dendritic Cells Induced by the B Pentamer of the Type II Heat-Labile Enterotoxin LT-IIa Requires Engagement of TLR2 (Vaccine) | Terry D. Connell, PhD |
| Chang Hoon Lee Hesham Nawar | LT-IIc, a New Member of the Type II Heat-Labile Enterotoxin Family, Exhibits Potent Immunomodulatory Properties That are Different From Those Induced by LT-IIa or LT-IIb (Vaccine) | Terry D. Connell, PhD |
| John C. Hu Hesham Nawar | LT-IIc, a New Member of the Type II Heat-Labile Enterotoxin Family Encoded by an Escherichia coli Strain Obtained From a Non-Mammalian Host (Infection and Immunity) | Terry D. Connell, PhD |
| Hua Peng | Role of the IE62 Consensus Binding Site in Transactivation by the Varicella-Zoster Virus IE62 Protein (Journal of Virology) | John Hay, PhD |
| Bardees Foda | TbRGG2 Facilitates Kinetoplastid RNA Editing Initiation and Progression Past Intrinsic Pause Sites (RNA) | Laurie K. Read, PhD |
| Brandon Feinen | Critical Role of Th17 Responses in a Murine Model of Neisseria gonorrhoeae Genital Infection (Mucosal Immunology) | Michael W. Russell, PhD |
2009
| Student | Title | Faculty Mentor |
|---|---|---|
| Jeremiah Davie | Comparative Proteomic Analysis of the Haemophilus ducreyi Porin-Deficient Mutant 35000HP::P2AB (Journal of Bacteriology) | Anthony A. Campagnari, PhD |
| Katie Edwards Johanna Schwingel | The Use of Moraxella catarrhalis Lipooligosaccharide Mutants to Identify Specific Oligosaccharide Epitopes Recognized by Human Serum Antibodies (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Hesham Nawar | Mapping of a Microbial Protein Domain Involved in Binding and Activation of the TLR2/TLR1 Heterodimer (Journal of Immunology) | Terry D. Connell, PhD |
| In Vivo and In Vitro Adjuvant Activities of the B Subunit of Type IIb Heat-Labile Enterotoxin (LT-IIb-B5) From Escherichia coli (Vaccine) | ||
| Chang Hoon Lee Hesham Nawar | Ganglioside-Linked Terminal Sialic Acid Moieties on Murine Macrophages Function as Attachment Receptors for Murine Noroviruses (Journal of Virology) | Terry D. Connell, PhD |
| Kimberly Prohaska | Assembly of the Trypanosoma brucei 60S Ribosomal Subunit Nuclear Export Complex Requires Trypanosome-Specific Proteins P34 and P37 (Eukaryotic Cell) | Noreen Williams, PhD |
2008
| Student | Title | Faculty Mentor |
|---|---|---|
| Thomas Loehfelm | Identification and Characterization of an Acinetobacter baumannii Biofilm-Associated Protein (Journal of Bacteriology) | Anthony A. Campagnari, PhD |
| Johanna Schwingel | Identification and Characterization of a Unique Glycosyltransferase Involved in the Assembly of the Inner Core of Moraxella catarrhalis Lipooligosaccharides (Glycobiology) | Anthony A. Campagnari, PhD |
| Jonelle Mattiacio | Roles for TbDSS-1 in RNA Surveillance and Decay of Maturation By-Products From the 12S rRNA Locus (Nucleic Acids Research) | Laurie K. Read, PhD |
2007
| Student | Title | Faculty Mentor |
|---|---|---|
| Pascale Plamondon | Identification of a Novel Two Partner Secretion System for Moraxella catarrhalis (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Kristin (Furano) Picardo | Identification of a Hemin Utilization Protein of Moraxella catarrhalis (HumA) (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Hesham Nawar | Mutants of Type II Heat-Labile Enterotoxin LT-IIa Exhibiting Altered Ganglioside-Binding Activities and Diminished Toxicities are Potent Mucosal Adjuvants (Infection and Immunity) | Terry D. Connell, PhD |
| In Vitro Induction of IgA- and IgM-Secreting Cells by Cholera Toxin Depends on T-Cell Help and is Mediated by CD154 Up-Regulation (Infection and Immunity) | ||
| Ganglioside GD1a is an Essential Co-receptor for Toll-Like Receptor 2 Signaling in Response to the B Subunit of Type IIb Enterotoxin (Journal of Biological Chemistry) | ||
| The A Subunit of Type IIb Enterotoxin (LT-IIb) Suppresses the Proinflammatory Potential of the B Subunit and its Ability to Recruit and Interact With TLR2 (Journal of Immunology) | ||
| Jeffrey Mocny | The Role of Spontaneous Loss of Heme From Hemoglobin and Myoglobin in Iron Acquisition by Bordetella bronchiseptica (Infection and Immunity) | Terry D. Connell, PhD |
| Christopher Goulah | Differential Effects of RBP16 Arginine Methylation on mRNA Binding, gRNA Binding and gRNP Formation (Journal of Biological Chemistry) | Laurie K. Read, PhD |
| Chia-Ying Kao | Targeted Delpetion of a Mitochondrial Nucleotidyltransferase Suggests the Action of Multiple Enzymes in the Formation RNA 3’ Tails in Trypanosoma brucei Mitochondria (Molecular and Biochemical Parasitology) | Laurie K. Read, PhD |
| Deborah Pasternack | Evolutionarily Divergent Type II Protein Arginine Methyltransferase in Trypanosoma brucei (Eukaryotic Cell) | Laurie K. Read, PhD |
| Martin Ciganda Kristina Hellman | Two Trypanosome-Specific Proteins are Essential Factors for 5S rRNA Abundance and Ribosomal Assembly in T. brucei (Eukaryotic Cell) | Noreen Williams, PhD |
| Kristina Hellman Kimberly Prohaska | T. brucei RNA Binding Proteins, p34 and p37, Mediate NOPP44/46 Localization via the Exportin 1 Pathway (Eukaryotic Cell) | Noreen Williams, PhD |
2006
| Student | Title | Faculty Mentor |
|---|---|---|
| Randolph Clower | The PV E2 Protein Interacts With and Stimulates DNA Topoisomerase I (Virology) | Thomas Melendy, PhD |
| Cellular Topoisomerase I Modulates Origin Binding by Bovine Papillomavirus Type 1 E1 (Journal of Virology) | ||
| John Fisk | Interactions of the Cellular CCAAT Displacement Protein and Human Papillomavirus E2 Proteins With the Viral Origin of Replication Can Regulate DNA Replication (Virology) | Thomas Melendy, PhD |
| Randolph Clower John Fisk | Papillomavirus E1 Protein Binds to and Stimulates Human Topoisomerase I (Journal of Virology) | Thomas Melendy, PhD |
| Chia-Ying Kao Christopher Ryan | Biphasic Decay of Guide RNAs in Trypanosoma brucei (Molecular and Biochemical Parasitology) | Laurie K. Read, PhD |
| Melissa Miller | RBP16 Stimulates Trypanosome RNA Editing In Vitro at an Early Step in the Editing Reaction (RNA) | Laurie K. Read, PhD |
| Christopher Goulah | Arginine Methylation Regulates Mitochondrial Gene Expression in Trypanosoma brucei Through Multiple Effector Proteins (RNA) | Laurie K. Read, PhD |
2005
| Student | Title | Faculty Mentor |
|---|---|---|
| Kristin (Furano) Picardo | Identification of a Conserved Moraxella catarrhalis Hemoglobin Utilization Protein (MhuA) (Microbiology) | Anthony A. Campagnari, PhD |
| Katie Edwards | Characterization of a Cluster of Three Glycosyltransferase Enzymes Essential for Moraxella catarrhalis Lipooligosaccharide Assembly (Journal of Bacteriology) | Anthony A. Campagnari, PhD |
| Katie Edwards Johanna Schwingel | Multiplex PCR Assay That Identifies the Major Lipooligosaccharide Serotype Expressed by Moraxella catarrhalis Clinical Isolates (Journal of Clinical Microbiology) | Anthony A. Campagnari, PhD |
| Hesham Nawar | Toll-Like Receptor 2 Mediates Cellular Activation by the B Subunits of Type II Heat-Labile Enterotoxins (Infection and Immunity) | Terry D. Connell, PhD |
| Mucosal Adjuvant Properties of Mutant LT-IIa and LT-IIb Enterotoxins That Exhibit Altered Ganglioside-Binding Activities (Infection and Immunity) | ||
| Differential Binding of Escherichia coli Enterotoxins LT-IIa and LT-IIb and of Cholera Toxin Elicits Differences in Apoptosis, Proliferation and Activation of Lymphoid Cells (Infection and Immunity) | ||
| Chia-Ying Kao | Opposing Effects of Polyadenylation on the Stability of Edited and Unedited Mitochondrial RNAs in Trypanosoma brucei (Molecular and Cellular Biology) | Laurie K. Read, PhD |
| Christopher Ryan | UTP-Stimulated Turnover of Polyadenylated Mitochondrial RNA Requires RNA Polymerization and Involves the RET1 TUTase (RNA) | Laurie K. Read, PhD |
| Deborah Pasternack | In Vitro and In Vivo Characterization of the Major Type I Protein Arginine Methyltransferase From Trypanosoma brucei (Molecular and Biochemical Parasitology) | Laurie K. Read, PhD |
2004
| Student | Title | Faculty Mentor |
|---|---|---|
| Kristin (Furano) Picardo | Identification of a Hemin Utilization Protein of Moraxella catarrhalis (HumA) (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Hesham Nawar | The Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb and Their Respective B Pentamers Differentially Induce and Regulate Cytokine Production in Human Monocytic Cells (Infection and Immunity) | Terry D. Connell, PhD |
| Min Yang | The DNA Element Controlling Expression of the VZV ORF 28 and 29 Genes Consists of Two Divergent Unidirectional Promoters Which Share a Common USF Site (Journal of Virology) | John Hay, PhD |
| Jonelle Mattiacio Penschow Christopher Ryan | TbDSS-1, an Essential Trypanosoma brucei Exoribonuclease Homolog That has Pleitropic Effects on Mitochondrial RNA Metabolism (Eukaryotic Cell) | Laurie K. Read, PhD |
2003
| Student | Title | Faculty Mentor |
|---|---|---|
| Kristin (Furano) Picardo | Inactivation of the Moraxella catarrhalis 7169 Ferric Uptake Regulator Increases Susceptibility to the Bactericidal Activity of Normal Human Sera (Infection and Immunity) | Anthony A. Campagnari, PhD |
| Hua Peng Min Yang | Cellular Factors and IE62 Activation of VZV Promoters (Journal of Medical Virology) | John Hay, PhD |
| Hua Peng | Interaction Between the VZV IE62 Major Transactivator and the Cellular Transcription Factor Sp1 (Journal of Biological Chemistry) | John Hay, PhD |
| Y.M. Loo | The Rep Protein of Adeno-Associated Virus (AAV) Interacts With Single-Stranded DNA-Binding Proteins That Enhance Viral Replication (Journal of Virology) | Thomas Melendy, PhD |
| Recruitment of Replication Protein A by the Papillomavirus E1 Protein and Modulation by Single-Stranded DNA (Journal of Virology) |